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Bone Abstracts (2016) 5 P297 | DOI: 10.1530/boneabs.5.P297

Institute of Metabolism and Endocrinology, The Second Xiang-Ya Hospital, Central South University, Changsha, China.


The effects of dexamethasone on trabecular and cortical bone in OPG−/− mice were investigated in present study. Forty 6-month-old C57BL/6J female mice, including wt (n=20) and OPG knockout (OPG−/−, n=20), were randomdly divided into four groups and treated with either sterile normal saline or dexamethasone at 1 mg/kg by intramuscular injection 3 days per week. All mice were sacrificed at 4 weeks after these treatments. Sera were harvested for biochemical analysis, while the fourth lumber vertebrae and left tibia were scanned by microCT. It was found that there was no significant difference in either CTX or P1NP in each group. In WT mice, dexamethasone did not induce any changes of bone parameters. While in OPG−/− mice, dramatic bone loss and micro-structural deteriorations in both lumbar trabecular and tibial cortical bone were found. However, it was also found that dexamethasone improved bone volume fraction, Tb.Th, Tb.N and decreased Tb.Sp as well as SMI in the tibial trabecuae of OPG−/− mice. This was firstly showed us that except for the expectedly bone-loss, dexamethasone could produce bone-spare effects in OPG−/− mice at specified bone sites.

Volume 5

43rd Annual European Calcified Tissue Society Congress

Rome, Italy
14 May 2016 - 17 May 2016

European Calcified Tissue Society 

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