Searchable abstracts of presentations at key conferences on calcified tissues

ba0004p24 | (1) | ICCBH2015

Bone status of Indian children and adolescents with type 1 diabetes mellitus

Mandlik Rubina , Parthasarathy Lavanya , Khadilkar Vaman , Chiplonkar Shashi , Phanse-Gupte Supriya , Kajale Neha , Mughal Zulf , Khadilkar Anuradha

Objective: Aim was to cross sectionally study bone health parameters assessed by DEXA and serum IGF1 concentrations in 6–16 year old children with type 1 diabetes. We hypothesized that height and bone parameters would be impaired in diabetic children compared with contemporary reference population.Method: Bone mineral content for total body (less head) (TBBMC) and lumbar spine was measured by DXA (n=170, 77 boys). Z-scores for TBBM...

ba0004p131 | (1) | ICCBH2015

Association between serum 25-hydroxyvitamin D and incidence of infections in 6--12 years old children in a semi-rural setting in Western Maharashtra, India

Mandlik Rubina , Kajale Neha , Chiplonkar Shashi , Patwardhan Vivek , Phanse-Gupte Supriya , Khadilkar Vaman , Mughal Zulf , Khadilkar Anuradha

Objectives: Previous studies have shown that burden of infections is greater in those with low body stores of vitamin D. Vitamin D is a key mediator of innate immunity and is crucial in production of cathelicidin, a potent antimicrobial agent. Vitamin D deficiency is common among Indian children; the prevalence of infections is high. Thus, aims of our study were to examine the association between: i) serum 25-hydroxyvitamin D (25OHD) concentrations and symptoms of infections a...

ba0006oc11 | (1) | ICCBH2017

The effect of whole body vibration training on bone and muscle function in children with osteogenesis imperfecta and limited mobility: a randomized controlled pilot trial

Hogler Wolfgang , Bishop Nick , Arundel Paul , Scott Janis , Mughal Zulf , Padidela Raja , Nightingale Peter , Shaw Nick , Crabtree Nicola

Objectives: Osteogenesis imperfecta (OI) is a bone fragility disorder associated with reduced muscle size, dynamic muscle function and mobility. This paired randomised controlled pilot study assessed the effect of whole body vibration (WBV) training on bone density and geometry, muscle size and function, mobility, and balance in children with OI.Methods: Twenty-four children (5–16 years) with OI types 1,4 and limited mobility (defined as a Childhood...

ba0006p156 | (1) | ICCBH2017

Bone health status of underprivileged Indian adolescent girls

Mandlik Rubina , Ekbote Veena , Kajale Neha , Jaiswal Anjali , Chiplonkar Sahshi , Khadilkar Vaman , Padidela Raja , Mughal Zulf , Khadilkar Anuradha

Objectives: Earlier studies performed using dual energy X-ray absorptiometry indicate that underprivileged Indian girls acquire low bone mass during adolescence. Therefore, aim was to assess bone geometry of underprivileged Indian adolescent girls (age 12–19 years) using peripheral quantitative computed tomography (pQCT).Methods: Fifty-six adolescent girls were assessed for anthropometry (height, weight) (February 2016 to January 2017) and pQCT (STR...

ba0006p162 | (1) | ICCBH2017

Nutritional rickets presenting to secondary care in children (<16 years) -- A UK surveillance study

Julies Priscilla , Pall Karina , Lynn Richard , Calder Alistair , Mughal Zulf , Shaw Nicholas , McDonnell Ciara , McDevitt Helen , Blair Mitchell

Objectives: Rickets is a disease of growing children with potentially serious short and long-term complications. The United Kingdom (UK) national incidence of Nutritional Rickets(NR) is unknown and thought to be increasing. This study aims to describe the incidence, presentation and clinical management of children with NR in the UK and Republic of Ireland.Methods: Data is being collected prospectively monthly between March 2015 and March 2017 from 3500 p...

ba0006lb11 | (1) | ICCBH2017

Bone health status as measured by DXA and pQCT in Indian Children with Thalassemia Major

Mandlik Rubina , Ekbote Veena , Ramanan Vijay , Kelkar Ketki , Pawar Jwala , Chiplonkar Shashi , Khadilkar Vaman , Khadilkar Anuradha , Padidela Raja , Mughal Zulf

Objective: Expansion of bone marrow, accumulation of iron, growth failure and delayed puberty affect bone health in thalassemia; data on bone density and geometry are scarce. Our objective was to assess bone density (by Dual Energy X-ray Absorptiometry, DXA) and geometry (by peripheral quantitative computed tomography, pQCT) in children with thalassemia major.Methods: Children with thalassemia were recruited from a hematology clinic in Pune (India) (Mean...

ba0006lb14 | (1) | ICCBH2017

P4HB recurrent missense mutation causing Cole-Carpenter syndrome: exploring the underlying mechanism

Balasubramanian Meena , Padidela Raja , Pollitt Rebecca , Bishop Nick , Mughal Zulf , Offiah Amaka , Wagner Bart , McCaughey Janine , Stephens David

Cole-Carpenter syndrome (CCS) is commonly classified as a rare Osteogenesis Imperfecta disorder. This was following the description of two unrelated patients with very similar phenotypes who were subsequently shown to have a heterozygous missense mutation in P4HB. Here, we report a 3-year old female patient who was diagnosed with a severe form of OI. Exome sequencing identified the same missense mutation in P4HB as reported in the original cohort, thus reinfo...

ba0007p89 | (1) | ICCBH2019

Use of DXA and pQCT measurements to screen for fracture risk in 3 to 18 year old poorly chelated thalassaemic children

Palande Sonal , Ekbote Veena , Chilplonkar Shashi , Chauthmal Sujata , Khadilkar Vaman , Ramanan Vijay , Khadilkar Anuradha , Padidela Raja , Mughal Zulf , Crabtree Nicola

Objectives: Low bone mineral density has been reported in children with beta thalassemia major, they also have increased propensity to fracture. We have studied DXA and pQCT variables in poorly chelated 3 to 18 year old thalassaemic patients and their relationship with fractures in this population.Methods: We studied 167, 3 to 18 year old children (Girls 72) with beta thalassemia major. Bone measurements were performed by GE iDXA (Lumbar Spine, Total bod...

ba0007p104 | (1) | ICCBH2019

Vitamin D deficiency nutritional rickets presenting to secondary care in children (<16 Years) – A United Kingdom surveillance study

Shaw Nick , Mughal Zulf , Julies Priscilla , Pall Karina , Lynn Richard , Leoni Marina , Calder Alistair , McDonnell Ciara , McDevitt Helen , Blair Mitch

Objectives: Nutritional Rickets (NR) is the commonest cause of rickets worldwide. Although the prevalence of rickets has been widely reported to be increasing, the actual national incidence of NR in the United Kingdom (UK) is unknown.Methods: Retrospective data were collected monthly between March 2015 and March 2017 from 3500 consultant paediatricians using British Paediatric Surveillance Unit (BPSU) reporting methodology. Clinicians completed an online...

ba0007p155 | (1) | ICCBH2019

Gender specific paediatric reference data for muscle function parameters assessed using jumping mechanography

Palande Sonal , Ekbote Veena , Chiplonkar Shashi , Padidela Raja , Mughal Zulf , Vispute Smruti , Rawer Rainer , Khadilkar Anuradha , Khadilkar Vaman

Objective: Bone adapts to mechanical stimuli by increasing its mass and changing geometry; muscles are the stimulators for this change as they induce forces through contractions. Thus, bone strength is driven by muscle function. Research has shown that muscle mass and muscle function may not be proportional and hence analysing muscle function becomes of crucial importance. Here we propose to establish gender specific paediatric reference data for muscle function parameters ass...