Searchable abstracts of presentations at key conferences on calcified tissues

ba0004p35 | (1) | ICCBH2015

Spinal muscular atrophy: another non-ambulatory population at risk for low bone mineral density

Kecskemethy Heidi , Bachrach Steven , Harcke H Theodore

In children with spinal muscular atrophy (SMA): i) describe bone mineral density (BMD) measured by dual-energy x-ray absorptiometry (DXA); ii) examine bone health factors; iii) examine change in BMD over time and pamidronate effect.DXA results, medications, ambulation, 25-OH-Vit D levels, and fracture history were retrospectively reviewed in 14 children (five girls) with SMA. Sites scanned included whole body (WB), lumbar spine (LS), and lateral distal f...

ba0002p148 | (1) | ICCBH2013

Low bone mineral density in a group of girls with Rett syndrome

Bachrach Steven , Kecskemethy Heidi , Harcke H Theodore , Schanen Carolyn

Objective: In girls with Rett syndromeDescribe bone mineral density (BMD) and contributing factors in a cross-section of subjects.Examine serial DXA measures.Examine effect of pamidronate on BMD over time.Methods: We reviewed the clinical course, medications, level of ambulation, 25-OH-Vit D levels, fracture history and DXA results in 13 girls with Rett syndrome. Eight subjects had more...

ba0007p176 | (1) | ICCBH2019

Prevalence of vitamin D deficiency in newly diagnosed children with cancer

Kecskemethy Heidi , Su Annelise , Bachrach Steven , Fullmer Michell

Objectives: 1) To determine the prevalence of Vitamin D deficiency in children with newly diagnosed cancer; 2) Compare Vitamin D levels of children with and without cancer; 3) Evaluate race and sex differences in Vitamin D levels.Methods: IRB approved retrospective review of medical records from our pediatric tertiary care center from 2011–2018. Inclusion criteria were serum 25-OH D within 3 months of oncology diagnosis and other non-oncology diagno...

ba0006p136 | (1) | ICCBH2017

Preliminary results for a ramping model of pamidronate administration

Givens Alyssa K , Bachrach Steven , Harcke H Theodore , Kecskemethy Heidi H

Objectives: Examine the effects of a ramped dosage schedule of pamidronate on BMD, fracture rate and location compared to a uniform 5-course regimen. The ramping regimen is intended to alter the tendency for post-treatment fractures to occur at the juncture of pamidronate bands where stress-riser related fractures have been described.Methods: Ten non-ambulatory children (seven females) with neuromuscular disabilities who received IV pamidronate with a ta...