Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp118 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2013

Role of estrogen replacement therapy in the control of immune system in postmenopausal osteoporosis

D'Amelio Patrizia , Sassi Francesca , Buondonno Ilaria , Fornelli Giorgia , Bonardo Elena , Isaia Giovanni Carlo

Introduction: We have recently shown that T cells play a key role in postmenopausal bone loss, here we investigate the influence of estrogen replacement therapy in the control of the immune system and osteoclastogenesis.Description of methods: We enrolled in the study 30 women with postmenopausal osteoporosis randomized to estrogen replacement therapy (HRT) or raloxifene (RLX) associated with calcium and vitamin D or calcium and vitamin D alone.<p cl...

ba0003pp305 | Osteoporosis: treatment | ECTS2014

Treatment with PTH 1--84 influences glucose metabolism trough undercarboxylated osteocalcin

D'Amelio Patrizia , Spertino Elena , Sassi Francesca , Buondonno Ilaria , Tamone Cristina , Piano Simonetta , Isaia Giovanni Carlo

In the recent years the role of the skeleton in glucose and energy homeostasis has been studied. In particular the osteoblast-specific protein osteocalcin (OC), in its undercarboxylated form (uOC) has been shown to influence glucose homeostasis in animal models.The aim of our study is to evaluate if the intermittent administration of 1–84 PTH could influence glucose metabolism through its anabolic action on the skeleton.We enr...

ba0003pp353 | Osteoporosis: treatment | ECTS2014

PTH treatment induces WNT10b expression in humans lymphoid cells

Patrizia D'Amelio , Sassi Francesca , Buondonno Ilaria , Spertino Elena , D'Amico Lucia , Roato Ilaria , Isaia Giovanni Carlo

Intermittent PTH reduces vertebral fractures risk in osteoporotic patients. The mechanisms trough which PTH acts are not completely understood, it has been observed to activate Wnt pathways in osteoblasts (OBs). Activation of this pathway induces OB proliferation, differentiation and prevents apoptosis. Recently increased expression of Wnt10b by T cells during intermittent PTH, and no increase during continuous PTH has been demonstrated in mice.In order to evaluate if PTH incr...

ba0005p4 | Arthritis and other joint diseases: translational and clinical | ECTS2016

Immune system and bone cells in early rheumatoid arthritis

Buondonno Ilaria , Sassi Francesca , Rigoni Micol , Rovera Guido , Isaia Giovanni Carlo , D'Amelio Patrizia

Rheumatoid arthritis (RA) is an immune-mediated disease characterized by T cells activation and bone erosions that severely reduces patients quality of life; however a clear role for different T helper (Th) cells has not been established yet.This work aims to evaluate Th phenotypes, osteoclast (OCs) precursors cells and cytokines in peripheral blood of women affected by early RA (eRA) compared to healthy women matched for age. The study was approved by o...