Searchable abstracts of presentations at key conferences on calcified tissues

ba0007p47 | (1) | ICCBH2019

Anorexia nervosa: weighing in on bone health surveillance: When should it be performed?

Ayya Mekhala , Crabtree Nicola , Shaw Nicholas

NICE guidelines (UK) recommend that bone mineral density (BMD) scans, corrected for bone size (bone mineral apparent density [BMAD]) should be performed for patients with anorexia nervosa (AN) when underweight for a year or more. The number of patients identified with low bone mineral density or vertebral fractures remains low in this population. However, referrals for dual- energy X-ray absorptiometry (DXA), vertebral fracture assessment (VFA) and peripheral quantitative comp...

ba0002p134 | (1) | ICCBH2013

Cessation of ambulation results in a dramatic loss of trabecular bone density in boys with Duchenne muscular dystrophy

Crabtree Nicola , Bebbington Natalie , Roper Helen , McMurchie Heather , Shaw Nicholas

Steroids are currently used to improve muscle strength and prolong ambulation in boys with Duchenne muscular dystrophy (DMD) although the effect on bone health is still unclear. The aim of this study was to compare bone strength in healthy children and boys with DMD and investigate the interaction between diminished muscle function, loss of ambulation and high dose oral steroids.Fifty children were studied, 14 healthy boys (HB), 13 boys with DMD who rema...

ba0002p135 | (1) | ICCBH2013

Is vertebral fracture assessment by DXA more useful in a high fracture risk paediatric population than in a low-risk screening population?

Crabtree Nicola , Chapman Steve , Hogler Wolfgang , Shaw Nicholas

Vertebral fracture assessment (VFA) by DXA is an accepted tool in adults. However, its use in children has not been validated. The aim of this study was to validate VFA using iDXA against spinal radiographic assessment (RA) for the identification of vertebral fractures in children.Spine radiographs and VFA (L5–T2) by GE-iDXA were acquired on the same day in 80 children. Forty children were considered high-risk for fracture as their metabolic bone sp...

ba0004p113 | (1) | ICCBH2015

Comparison of cost benefits and efficacy of Zoledronic acid and Pamidronate in the treatment of osteogenesis imperfecta in children

Saraff Vrinda , Sahota Jaskiran , Crabtree Nicola , Shaw Nick , Hogler Wolfgang

Intravenous (IV) Pamidronate (PAM) has been used in the treatment of Osteogenesis Imperfecta (OI) and is known to increase bone mineral density (BMD) and reduce the incidence of fractures. However an attractive alternative is the more potent IV Zoledronic acid (ZOL).Objectives: To determine the clinical efficacy of IV PAM vs ZOL in children with mild to moderate OI and compare the cost benefits of the two drugs.Methods: A retrospec...

ba0004p123 | (1) | ICCBH2015

Does the introduction of vertebral fracture assessment change clinical practice?

Chapman Dee , Walford Jacky , Shaw Nicholas , Hogler Wolfgang , Crabtree Nicola

Introduction: Since the definition of osteoporosis in children changed following the revised ISCD guidelines of 2013, the presence of vertebral fractures has become more clinically important, in particular since vertebral fractures may occur despite apparently normal bone density ( Although the detection of vertebral fractures in children is still largely dependent on lateral spine x-rays, the introduction of new higher resolutio...

ba0006oc17 | (1) | ICCBH2017

Vertebral Fractures in children with chronic inflammatory and/or disabling conditions: the SNAP study

Crabtree Nicola , Hogler Wolfgang , Chapman Dee , Walford Jacky , Shaw Nicholas

Objectives: The SNAP study is a prospective fracture study of children with chronic inflammatory and/or disabling conditions. The overall study aim is to assess causal links between body-size adjusted bone density and low trauma fracture.Methods: 330 children aged 5–18 years were recruited from seven disease groups namely; acute lymphoblastic leukaemia (ALL), rheumatological disease, inflammatory bowel disease, cystic fibrosis, coeliac disease, Duch...

ba0006p147 | (1) | ICCBH2017

Bone health in boys with Duchenne muscular dystrophy (DMD): the dichotomy between bone density and fracture

Crabtree Nicola , Hogler Wolfgang , Roper Helen , Shaw Nicholas

Objectives: Current guidelines recommend annual assessments of bone densitometry in boys with Duchenne muscular dystrophy (DMD). However, this recommendation is based on the assumption that bone density is a predictor of fractures in this patient group. The aim of this study was to evaluate the relationships between long-term changes in bone density, corticosteroid exposure and mobility with vertebral and long bone fractures.Methods: Twenty-four DMD boys...

ba0007p66 | (1) | ICCBH2019

Bone densitometry and body composition in children with hypophosphatasia

Mciver William , Whittaker Lucy , Crabtree Nicola , Hogler Wolfgang , Saraff Vrinda

Hypophosphatasia (HPP) is a rare genetic disease characterised by low tissue-nonspecific alkaline phosphatase activity, causing defective mineralisation of bone and teeth. There is limited data on the measurement of bone mineral density (BMD) and body composition in these children.Objectives: To assess whether BMD and lean body mass (LBM) in treatment naïve children with HPP correlate with functional outcomes using the 6-minute walk test (6MWT)....

ba0004op8 | (1) | ICCBH2015

Characterising the muscle-bone unit in children and adolescents with and without cystic fibrosis using novel imaging techniques and jumping mechanography

Riddell Amy , Crabtree Nicola , Ross-Russell Robert , Solis-Trapala Ivonne , Prentice Ann , Ward Kate

Cystic fibrosis(CF) results in low volumetric bone mineral density(vBMD), poor muscle strength and increased fracture risk in young patients. The aim of this study was to compare bone and muscle variables measured by peripheral and high-resolution QCT (pQCT and HR-pQCT) and jumping mechanography (JM) In CF children and healthy controls. We hypothesised that CF children have lower muscle force and power (Fmax and Pmax) than controls which may contribute to CF-related bone disea...

ba0004p120 | (1) | ICCBH2015

Fracture incidence and bisphosphonate therapy in boys with Duchenne Muscular Dystrophy

Crabtree Nicola , Hogler Wolfgang , Sahota Jaskiran , Chapman Dee , Walford Jacky , Roper Helen , Willis Tracy , Shaw Nicholas

Background: DMD is a progressive neuromuscular disease often treated with oral glucocorticoids (GC) to prolong ambulation and maintain cardiovascular function. However, the osteotoxic GC effects often result in a skeleton prone to fractures. DMD boys presenting with fractures are treated with bisphosphonates (BP) but evidence of beneficial effects is limited. The aim of this work was to review the use of intravenous BPs in a group of severely affected boys with fractures.<...