Searchable abstracts of presentations at key conferences on calcified tissues

ba0006p152 | (1) | ICCBH2017

Seasonal variation in internet searches for vitamin D

Moon Rebecca , Curtis Elizabeth , Davies Justin , Cooper Cyrus , Harvey Nicholas

Objective: Over the last decade, there has been increasing scientific interest in vitamin D, and it is now advised that all pregnant women and infants should receive vitamin D supplementation. Despite of this, it is recognized that knowledge of vitamin D in the general public is limited. The internet is now an important source of health care information and analysis of internet search activity rates can provide information on disease epidemiology, health related behaviors and ...

ba0007p167 | (1) | ICCBH2019

Children's multivitamins do not contain sufficient vitamin D

Moon Rebecca , Curtis Elizabeth , Cooper Cyrus , Davies Justin , Harvey Nicholas

Objective: Public Health England recommends that children in the United Kingdom (UK) aged over 1 year should take a vitamin D supplement containing 400 IU/day. Commercially available children’s multivitamin and vitamin D supplements were surveyed to determine the vitamin D content.Methods: Multivitamins and vitamin D supplements marketed at children <12 years and sold by nine UK supermarkets and health supplement retailers were surveyed. The vit...

ba0007oc4 | (1) | ICCBH2019

Early life vitamin D depletion and mechanical loading determine methylation changes in the RXRA, Runx2 and osterix promoters in mice

Borg Stephanie , Krstic Nevena , Buckley Harriet , Curtis Elizabeth , Cooper Cyrus , Lillycrop Karen , Harvey Nick , Skerry Tim , Bishop Nick

Objectives: Maternal vitamin D status in pregnancy is associated with neonatal bone mass, and altered DNA methylation. Mice exposed to early life vitamin D deficiency have lower bone mass and reduced bone accrual in response to mechanical loading. Using tibias from these mice we assessed DNA methylation of promoters of genetic loci important for bone growth and development.Methods: C57/BL6 mice received a vitamin D replete or deplete diet for 6 weeks per...

ba0007oc5 | (1) | ICCBH2019

Low birthweight is associated with poorer limb muscle mass and grip strength in middle age: findings from the UK Biobank Imaging Enhancement

Curtis Elizabeth , Liu Justin , Ward Kate , Jameson Karen , Raisi-Estabragh Zahra , Bell Jimmy , Petersen Steffen , Cooper Cyrus , Harvey Nicholas

Objectives: Low birthweight has been shown to be associated with poorer musculoskeletal health in later life in a variety of epidemiological studies. We investigated relationships between birthweight, and grip strength or magnetic resonance imaging (MRI) measures of muscle volume in UK Biobank.Methods: UK Biobank is a large prospective cohort of men and women aged 40–69 years, including a detailed baseline assessment in which birthweight was collect...

ba0006oc4 | (1) | ICCBH2017

25-hydroxyvitamin D response to antenatal cholecalciferol supplementation is associated with common vitamin D related genetic variants: findings from the MAVIDOS trial

Moon Rebecca , Harvey Nicholas , Cooper Cyrus , D'Angelo Stefania , Curtis Elizabeth , Crozier Sarah , Robinson Sian , Graham Nikki , Holloway John , Bishop Nicholas , Kennedy Stephen , Papageorghiou Aris , Schoenmakers Inez , Fraser Robert , Gandhi Saurabh , Prentice Ann , Inskip Hazel , Javaid Kassim

Objectives: Single nucleotide polymorphisms (SNP) in genes related to vitamin D metabolism have been associated with 25-hydroxyvitamin D (25(OH)D) status, but these relationships have not been examined in pregnancy or following antenatal vitamin D supplementation. We assessed whether SNPs in DHCR7 (7-dehydrocholesterol reductase), CYP2R1 (25-hydroxylase), CYP24A1 (24-hydroxylase) and GC (Vitamin D binding protein) were associated with the re...