Searchable abstracts of presentations at key conferences on calcified tissues

ba0002is18 | (1) | ICCBH2013

Obesity and skeletal health

Dimitri Paul

Child and adolescent obesity has reached epidemic proportions worldwide. The impact of excess fat on musculoskeletal health is of significant concern. Abnormal mechanical loading of the lower limbs in obese children may lead to anatomic alterations and an increased prevalence of slipped capital femoral epiphysis and tibia vara. Obese children are also over-represented in fracture groups and excess fat may result in low bone mass relative to body size, although this effect may ...

ba0002is18biog | (1) | ICCBH2013

Obesity and skeletal health

Dimitri Paul

Biographical DetailsDr P Dimitri studied Medicine at the University of St Andrew’s in Scotland and the University of Manchester where he received a medal in pathology and a distinction in Paediatrics. In 2010 he was awarded a PhD in Medicine and the Michael Blacow Award from the Royal College of Paediatrics and Child Health for his work on the relationship of fat and bone in children...

ba0004p118 | (1) | ICCBH2015

Changes in total body and regional bone mass in relation to body composition in children with osteogenesis imperfecta treated with pamidronate

Sritharan Shironisha , Gopal-Kothandapani Jaya Sujatha , Bishop Nick , Dimitri Paul

Background: In patients with osteogenesis imperfecta (OI), a rise in age-specific total body and regional bone mass is well recognised. In contrast changes in body size-adjusted bone mass in relation to changes in body composition following pamidronate therapy remain relatively unexplored.Methods: Changes in total and regional bone mass in relation to body composition in children with OI receiving pamidronate (3 mg/kg per day over 3 days, 3 monthly) were...

ba0004oc2 | (1) | ICCBH2015

Feature-based recognition of trabecular microstructure using 1.5T magnetic resonance imaging: a new methodology

Dimitri Paul , Lekadir Karim , Hoogendoorn Corne , Armitage Paul , Whitby Elspeth , King David , Frangi Alejandro

Background: Magnetic resonance imaging (MRI) is used clinically to assess bone marrow, muscle and joints. The assessment of cortical and trabecular structure using MRI may provide further insight into the muscle–bone–bone marrow unit. Previous studies using MRI to evaluate microarchitecture are confined to research due to the need for specially adapted coils and navigator software to limit motion artifact. We present a novel statistical method using HRpQCT to determi...

ba0004p153 | (1) | ICCBH2015

In-vivo high-resolution peripheral quantitative computer tomography assessment of skeletal microstructure in children with osteogenesis imperfecta

Digby Maria , Dimitri Paul , Arundel Paul , Bishop Nick , Paggiosi Margaret , Offiah Amaka

Objectives: The clinical assessment of bone mass in children with osteogenesis imperfecta (OI) is normally assessed by DXA. Further information about bone microarchitecture is obtained from bone biopsy which is invasive and requires anaesthetic. High-resolution peripheral quantitative computer tomography (HRpQCT) is an in-vivo imaging modality capable of assessing skeletal microstructure and integrity to a resolution of 80 μm. To date, no HRpQCT studies have incl...

ba0007p188 | (1) | ICCBH2019

Impact of type 1 diabetes mellitus on skeletal integrity and strength in adolescents aged 12 to 16 years; as assessed by High Resolution peripheral Quantitative Computed Tomography (HRpQCT)

Devaraja Janani , Dimitri Paul , Paggiosi Margaret , Clark Carolyn , Jacques Richard , Bishop Nick

Objectives: To investigate the impact of Type 1 Diabetes Mellitus (T1DM) on cortical and trabecular microarchitecture, and bone strength in adolescents; using High Resolution peripheral Quantitative Computed Tomography (HRpQCT) and microfinite element analysis. To our knowledge, this is the first study in children, assessing the impact of T1DM on skeletal microstructure and strength using HRpQCT.Methods: We recruited 22 patients aged 12–16 years wit...