Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p142 | Cell biology: osteoblasts and bone formation | ECTS2016

Regulation of genes involved in the integrin signalling pathway induced by titanium with nanotopography

Lopes Helena , Freitas Gileade , Florio Pedro , de Oliveira Paulo , Rosa Adalberto , Beloti Marcio

Titanium (Ti) surface with nanotopography induces osteoblast differentiation, at least in part, by upregulating the expression of α1/β1 integrins. Thus, we hypothesized that other potential candidates from the integrin signalling pathway may be involved in the osteogenic potential of nanotopography. In this context, the aim of this study was to compare the expression of integrin family members of cells grown on nanotopography with machined surface. Machined Ti discs ...

ba0005p53 | Bone development/growth and fracture repair | ECTS2016

Effect of bioactive glass-ceramic scaffold associated with bone marrow - or adipose-derived mesenchymal stem cells on bone formation under osteoporotic conditions

Freitas Gileade , Lopes Helena , Almeida Adriana , de Souza Luiz , Siessere Selma , Regalo Simone , Beloti Marcio , Rosa Adalberto

In this study, we evaluated the effect of the association of a bioactive glass-ceramic scaffold (Biosca) with mesenchymal stem cells derived from either bone marrow (BM-MSCs) or adipose tissue (AT-MSCs) on bone formation in calvarial defects of osteoporotic rats. Wistar rats were submitted to bilateral ovariectomy (OVX) or only to the surgical stress (Sham), under approval of the Committee of Ethics in Animal Research. After 5 months, 5-mm unilateral calvarial defect was creat...