Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p113 | Cancer and bone: basic, translational and clinical | ECTS2016

Dendritic glycopolymers as efficient drug delivery systems for retarded release of bortezomib from calcium phosphate cements

Mamitzsch Bettina , Striegler Christin , Schumacher Matthias , Gelinsky Michael , Muller Martin , Seckinger Anja , Voit Brigitte , Appelhans Dietmar

Calcium phosphate cements (CPC) are used as bone graft substitute, e.g. in the treatment of lytic bone lesions in multiple myeloma. CPC provide crucial advantages, such as osteoconductivity, biodegradability and the potential drug loading. Though, it lacks retarded drug release for short-/long-term treatment due to the free diffusion of small molecules through the micropores in the CPC.Thus we present dendritic glycopolymers (DG) consisting of poly(ethyl...

ba0001pp72 | Bone development/growth and fracture repair | ECTS2013

Calcium phosphate cement/strontium enhances bone formation in the metaphyseal osteoporotic fracture

Khassawna Thaqif El , Ray Seemun , Thormann Ulrich , Lips Katrin , Gelinsky Michael , Schumacher Matthias , Langheinrich Alexander Claus , Schnettler Reinhard , Alt Volker

Objective: Oosteoporoti fractures are a growing problem especially in aged societies of industrialized countries. Therefore, a clinical demand for synthetic bone graft substitutes is increasing. Despite the general success CPC showed clinically, development of CPC-based material by adding stronsium could improve its suitability to treat osteoporotic fractures.Methods: Sprague–Dawley rates model of induced osteoporosis via multi-deficiencies diet com...