Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp317 | Osteoporosis: evaluation and imaging | ECTS2013

A 3D QCT technique of the thoracic and lumbar spine: integral volume and intervertebral disc space increase and bmd decreases from T6 to L4

Museyko Oleg , Heinemann Axel , Krause Mattias , Barkmann Reinhard , Amling Michael , Gluer Claus , Puschel Klaus , Engelke Klaus

Introduction: QCT of the spine is typically restricted to the BMD analysis of the lumbar vertebrae. However, fractures frequently occur in the thoracolumbar region. Also the load distribution in the spine may depend on the intervertebral disc space (IDS), a good approximation of the intervertebral disc, which itself cannot be reliably assessed by X-ray based methods.Materials and methods: A QCT 3D acquisition and automated analysis technique (with option...

ba0001pp318 | Osteoporosis: evaluation and imaging | ECTS2013

Binding kinetics of fluorescent bisphosphonates as a tool for monitoring bone dynamics in vivo

Tower Robert , Campbell Graeme , Muller Marc , Will Olga , Grundmann Frederieka , Schem Christian , Gluer Claus , Tiwari Sanjay

Bone resorption and deposition occur in a tightly regulated fashion reflecting the coupled activities of osteoclasts and osteoblasts. Several pathological conditions perturb this balance between bone synthesis and resorption, including osteoporosis and skeletal metastases. The uncoupling of remodeling activities contributes to disseminated tumor cells homing to the bone and to tumor growth in bone. Therefore, a reliable marker of bone remodeling would be useful to provide a st...

ba0003pp225 | Osteoporosis: evaluation and imaging | ECTS2014

Utilizing bisphosphonate binding kinetics and soft tissue-derived input functions to differentiate changes in long bone and vertebra bone metabolism using in vivo fluorescent molecular tomography

Tower Robert J , Muller Marc , Will Olga , Tiwari Sanjay , Gluer Claus C , Campbell Graeme M

Bone resorption and formation occur in a tightly regulated fashion reflecting the coupled activities of osteoclasts and osteoblasts. Several pathological conditions perturb this balance, including osteoporosis and skeletal metastases. In the case of metastases, the uncoupling of resorption and formation activities contributes to disseminated tumor cells homing to the bone and to tumor growth within the bone in highly localized regions. Therefore, a site-specific marker of bone...

ba0003pp236 | Osteoporosis: evaluation and imaging | ECTS2014

Improved assessment of vertebral cortex thickness by means of analytical deconvolution of radial bone mineral density distributions

Damm Timo , Pena Jaime , Bastgen Jan , Krause Matthias , Campbell Graeme , Barkmann Reinhard , Gluer Claus-Christian

New treatment agents against osteoporosis may not only lead to an improved trabecular structure, but can probably also strengthen the cortex. To assess this treatment effects by means of QCT, one has to deal with significant partial volume effects observing this very thin, but compact structure. A new method for cortical thickness estimation has been developed using an analytical deconvolution approach. After estimating the point-spread-function (PSF) of a scanner/kernel combi...

ba0003pp323 | Osteoporosis: treatment | ECTS2014

To decline screening for osteoporosis: a study on individual decision making, meaning and reasons for non-participation

Rothmann Mette , Huniche Lotte , Ammentorp Jette , Brakmann Reinhard , Gluer Claus C , Hermann Anne Pernille

Purpose: This combined qualitative and quantitative study aimed to investigate women’s personal reasons for and choices to decline the screening for osteoporosis. The ROSE study is a randomized prospective population-based trial investigating the efficacy of a screening program to prevent fractures in women aged 65–80 years.Methods: A triangulated approach combining data from interviews and questionnaire. 7020 questionnaires from the screening ...

ba0005oc1.6 | Clinical trials and osteoporosis treatment | ECTS2016

Standard QCT shows substantial underestimation of treatment effects on bone mineral density: impact of spatial resolution

Reinhold Stefan , Damm Timo , Pena Jaime , Barkmann Reinhard , Gluer Claus-C

Quantitative Computed Tomography (QCT) can be performed with different protocols. We investigated whether selection of spatial resolution, reconstruction method, and scanner type have an impact on measured treatment effects for different bone compartments.Methods: In a multi-center study, a group of 50 men, age 55.1 (range 25–78) undergoing 18 months of either osteoanabolic (n=25) or antiresorptive treatment (n=25) were scanned wit...

ba0005p489 | Preclinical and ex vivo imaging | ECTS2016

Quantitative assessment of radial bone structural distribution in the proximity of degradable implants by micro-computed tomography

Damm Timo , Barkmann Reinhard , Galli Silvia , Willumeit-Romer Regine , Gluer Claus-Christian

Degradable bone implants may provide improved long-term healing, tissue remodeling and quality of life. In order to optimize alloy composition and degradation properties, in-vivo monitoring of the degradation process and its impact on bone formation is essential because degradation progresses differently in-vivo versus in-vitro. We aim to understand how degradation of magnesium alloy implants influences bone remodeling and bone structure using Micro-...

ba0005lb18 | (1) | ECTS2016

Evidence that CD146 positive bone marrow stromal cells in bone metastases have an inhibitory role in regulating tumor growth

Tietgen Maren , Damm Timo , Lenk Lennart , Desel Christine , Sebens Susanne , Gluer Claus-C , Tiwari Sanjay

The concept of the vicious cycle of bone metastases emphasizes the cross-talk between osteoclasts, osteoblasts and tumor cells, but the role of bone marrow stromal cells (BMSCs) is not well delineated. BMSCs comprise of a fibroblast-like cell population which adhere to culture flask and have an ability to differentiate into osteoblasts, adipocytes and chondrocytes. They express a panel of cell surface antigens which includes CD105, CD73, CD90, CD106, and CD146. In this study w...