Searchable abstracts of presentations at key conferences on calcified tissues

ba0001oc1.2 | Osteoporosis epidemiology and long term treatment complications | ECTS2013

Hip fractures and bone mineral density of the elderly: importance of serum 25-hydroxy vitamin D

Steingrimsdottir Laufey , Halldorsson Thorhallur , Siggeirsdottir Kristin , Cotch Mary Frances , Eiriksdottir Gudny , Sigurdsson Sigurdur , Harris Tamara , Gudnason Vilmundur , Sigurdsson Gunnar

Introduction: Vitamin D is known to be important for bone health. Still, the significance of serum 25-hydroxy vitamin D concentrations (s-25OHD) for hip fracture risk of the elderly is uncertain. Discordant findings may in part be explained by difficulties of RCTs or large cohort studies to reach both the frail and the healthy elderly. The objectives of this study were to determine the risk of hip fractures of the elderly related to s-25OHD, including both the frail and the he...

ba0001pp387 | Osteoporosis: pathophysiology and epidemiology | ECTS2013

Sclerostin associated with vertebral bone marrow fat in older men but not women

Ma Vivian , Li Xiaojuan , Sigurdsson Sigurdur , Eriksdottir Gudny , Hauksdottir Alda , Palermo Lisa , Hue Trisha , Lang Thomas , Harris Tamara , Rosen Clifford , Vittinghoff Eric , Siggeirsdottir Kristin , Sigurdsson Gunnar , Oskarsdottir Diana , Gudnason Vilmundur , Schwartz Ann

Previous studies found a negative correlation between vertebral bone marrow fat (MF) and bone density (BMD). Proposed mechanisms for this include i) a shift in stem cell lineage allocation from osteoblasts towards adipocytes, and ii) an increase in osteoclast-promoting cytokines with greater MF. However, little is known about the relationship between MF and bone markers. To assess these relationships in older adults, we used data from the AGES-Reykjavik cohort. MF was measured...

ba0005oc5.1 | Risk factors for fracture, Pagets disease of bone and musle and bone | ECTS2016

High serum miRNA 550a-5p levels are risk factors for incident fractures in older postmenopausal women with type 2 diabetes

Heilmeier Ursula , Hackl Matthias , Skalicky Susanna , Weilner Sylvia , Schroeder Fabian , Vierlinger Klemens , Lobach Iryna , Eiriksdottir Gudny , Aspelund Thor , Gudmundsson Elias , Grillari Johannes , Harris Tamara , Link Thomas , Gudnasson Vilmundur , Schwartz Ann

Standard DXA measurements, including FRAX scores, are limited in assessing fracture risk in type 2 diabetes (T2D). Novel, general applicable biomarkers are therefore needed. MicroRNAs (miRNAs) are secreted into the circulation from cells of various tissues proportional to local disease severity. Serum miRNA classifiers including miR-550a-5p were recently found to discriminate T2D women without and with prevalent fragility fractures with high specificity and sensitivity (AUC&#6...

ba0001pp283 | Genetics | ECTS2013

Discovery and replication of several loci significantly associated with lean body mass: a large meta-analysis of genome wide association studies (GWAS) from the ‘charge’ and ‘gefos’ consortia

Kiel Douglas P , Yerges-Armstrong Laura M , Hsu Yi-Hsiang , Stolk Lisette , Karasik David , Loos Ruth J F , Gudnason Vilmundar , Smith Albert , O'Connell Jeffrey R , Fu Amish , Fu Mao , Streeten Elizabeth A , Cauley Jane A , Robbins John A , Psaty Bruce , Johnson Toby , Kutalik Zoltan , Mitchell Braxton D , Livshits Gregory , Harris Tamara B , Ohlsson Claes , Zillikens M Carola

Introduction: The creatine kinase (CK) is a dimeric enzyme, involved in energetical metabolism. It is present in many tissues, but higher concentration in skeletal and cardiac muscle.Therefore, conditions that involve muscle tissue may increase this serum enzyme. Such enzyme elevation is usually observed in inflammatory myopathies and others autoimmune diseases.Sometimes some elevation in CK is not fully understood out off these co...

ba0005oc2.3 | Bone mass and bone strength Wnt signalling | ECTS2016

Life-course GWAS approach for total body BMD unveils 16 new BMD loci with some exerting age-specific effects

Medina-Gomez Carolina , Kemp John , Chesi Alessandra , Kreiner-Moller Eskil , Harris Tamara , Mook Dennis , Hatwig Fernando , Joro Raimo , Nedeljkovic Ivana , Evans Dan , Mullin Benjamin , Ohlsson Claes , Styrkarsdottir Unnur , Karasik David , McGuigan Fiona , Kiel Doug , Uitterlinden Andre , Tobias Jon , Evans Dave , Rivadeneira Fernando

Introduction: Bone mineral density (BMD) is a highly heritable trait used to assess skeletal health in children and risk of osteoporosis later in life. To date >60 loci associated with bone-related traits measured at different skeletal sites have been identified. We conducted a genome-wide association study (GWAS) meta-analysis of total body (TB-)BMD in children and adults to identify genetic determinants and age-specific effects of loci on this trait.<p class="abstext...