Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p70 | Bone development/growth and fracture repair | ECTS2016

Is heparin effective for the controlled delivery of high dose bone morphogeneic protein-2?

Kim In Sook , Kim Ri Youn , Hwang Soon Jung

Sustained release of bone morphogeneic protein (BMP)-2 by heparin-contained biomaterials is advantageous for bone tissue regeneration using low dose BMP-2. However, its effect in high dose BMP-2 is still unclear and should be clarified considering the clinical use of high dose of BMP-2 in spine and oral surgery. This study aimed to evaluate the efficacy of heparin-conjugated collagen sponge (HCS) in high dose BMP-2 delivery by investigating in vivo initial osteogenic regulatio...

ba0005p175 | Cell biology: osteoclasts and bone resorption | ECTS2016

A jumonji histone demethylase inhibits osteoclast differentiation through NFATc1 regulation

Chun Yang-Sook , Kim Seoun-Soung , Kim Hye-Jin , Park Jong-Wan

Osteoclasts are bone-resorbing multinucleated cells that differentiate from monocyte/macrophage-lineage precursors. Bone destruction and osteoporosis are attributed to excessively activated osteoclasts. Osteoclast differentiation is governed by diverse regulatory processes including nuclear factor-activated T cells c1 (NFATc1) activation in response to RANKL. The mechanism of epigenetic regulation of NFATc1 in osteoclastogenesis not investigated yet. Here we test a hypothesis ...