Searchable abstracts of presentations at key conferences on calcified tissues

ba0004p102 | (1) | ICCBH2015

Bone robusticity in two distinct skeletal dysplasias: an evaluation of the second metacarpal, a surrogate for bone strength

Marino Josephine , Jepsen Karl , Carter Erin , Raggio Cathleen

Radiographs of the second metacarpal are used to assess bone strength development in paediatric populations. Children with achondroplasia and osteogenesis imperfecta (OI) have known differences in bone strength. Details of how bone strength develops and compares within these populations to unaffected children are lacking. A data set for patients with achondroplasia and OI was established.A retrospective IRB-approved review of bone-age films (n=6...

ba0004oc11 | (1) | ICCBH2015

Comparison of RANKL blockade and bisphosphonate anti-resorptive therapies in a growing mouse model of OI: implications of prolonged treatment on bone health

Marino Josephine , Pleshko Nancy , Doty Stephen , Carter Erin , Jepsen Karl , Boskey Adele , Raggio Cathleen

Objective: The purpose of this ongoing study was to determine whether osteogenesis imperfecta (OI) patients entering adulthood should continue with bisphosphonate therapy or would benefit from switching to a RANKL blockade therapy. To address this question, we used a mouse model of type-III OI.Methods: Under IACUC-approval, +/+ and oim/oim mice were treated from 2–26 weeks (n=20/treatment/genotype) with either 1) saline 24 weeks; 2...

ba0007p7 | (1) | ICCBH2019

Bone morphology patterns in children with osteogenesis imperfecta

Citron Kate , Yonko Elizabeth , Khan Sobiah , Carter Erin , Jepsen Karl , Raggio Cathleen

Objectives: The objective of this study is to characterize patterns of bone morphology in children with osteogenesis imperfecta (OI), using measurements of the second metacarpal. A secondary objective is to look for impact of bisphosphonate treatment on bone morphology in this population.Methods: This is an IRB-approved retrospective review of 82 de-identified bone age films (AP hand/wrist) for 42 children with OI (17M, 25F). Measurements (Sectra IDS 7 P...