Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p70 | Bone development/growth and fracture repair | ECTS2016

Is heparin effective for the controlled delivery of high dose bone morphogeneic protein-2?

Kim In Sook , Kim Ri Youn , Hwang Soon Jung

Sustained release of bone morphogeneic protein (BMP)-2 by heparin-contained biomaterials is advantageous for bone tissue regeneration using low dose BMP-2. However, its effect in high dose BMP-2 is still unclear and should be clarified considering the clinical use of high dose of BMP-2 in spine and oral surgery. This study aimed to evaluate the efficacy of heparin-conjugated collagen sponge (HCS) in high dose BMP-2 delivery by investigating in vivo initial osteogenic regulatio...

ba0001pp198 | Cell biology: osteoblasts and bone formation | ECTS2013

Estrogen effect on the sclerostin induction by BMP-2 in human mesenchymal stromal cells

Kim In Sook , Yang Hoon Joo , Song Yun Mi , Ryu Soo Jin , Kim Ri Youn , Hwang Soon Jung

Introduction: Estrogen therapy decreases circulating levels of sclerostin, a protein product of SOST which increase in postmenopausal women. However, the mechanisms of estrogen on the expression of SOST remain unclear. This study was hypothesized that estrogen modulates SOST expression by interfering bone morphogenic protein (BMP) signaling on the basis that BMP is an inducer of SOST in osteoblasts.Description of methods: We investigated the expression o...

ba0003pp129 | Cell biology: osteoblasts and bone formation | ECTS2014

Modulation of sclerostin expression by estrogen via BMP-2 signaling in human mesenchymal stromal cells and osteoblasts

Kim Ri Youn , Yang Hoon Joo , Song Yun Mi , Cho Tae Hyung , Hwang Soon Jung , Kim In Sook

Little is known about the molecular mechanisms underlying the interaction between Sclerostin (SOST) and estrogen, showing an inverse relation in clinical data. Therefore, we investigated mechanisms by which estrogen modulates Sost expression at human osteoblastic cell level in association with BMP-2 signaling, which is a potential route of SOST induction. BMP-2 significantly induced SOST expression, which is suppressed by 17β-estradiol (E2) in human mesenchymal s...