Bone Abstracts

Objectives: AIS is associated with both low bone mass and elevated serum bone alkaline phosphatase. The greater the latitude of the geographical region, the higher is the prevalence of AIS. These specific features were compatible with the presence of either Vit-D insufficiency or abnormal physiology with Vit-D. It is important to evaluate these potentially treatable conditions regarding their roles in the etiopathogenesis of AIS. The objectives of this case-control study were ...

Objectives: Multiple studies have documented the presence of systemic osteopenia in adolescent idiopathic scoliosis and in simulated animal models. Osteopenia was also found to be associated with severe curves and as one of the prognostic factor in predicting curve progression in AIS. The objective of this study was to compare the bone quality and its association with osteopenia between AIS and normal controls.Methods: AIS (n=234) and non-AIS gi...

Introduction: Adolescent idiopathic scoliosis (AIS) is associated with osteopenia, which was found to be a significant prognostic factor for curve progression. However, in-depth quantitative assessment of bone quality was previously hampered by invasive nature of the investigations. The recently available high-resolution pQCT (HR-pQCT) allows a three-dimensional assessment of the bone quality in-vivo. This study aimed to evaluate and compare the bone quality in AIS gi...

Objectives: Adolescent idiopathic scoliosis (AIS) was associated with low bone mass which, apart from being an important health issue that could persist into adulthood, was also a significant prognostic factor for curve progression in AIS. We have performed a randomized controlled trial on whole-body vibration (WBV) and reported its effect on increasing femoral neck areal bone mineral density (aBMD) mainly at the dominant leg. The objective of this study was to evaluate the ro...

Objectives: Adolescent idiopathic scoliosis (AIS) is a complex three-dimensional spinal deformity associated with low bone mass. Our previous clinical trial demonstrated the anabolic bone effect of vibration treatment (VT) at the femoral neck in AIS subjects. The therapeutic effect was more pronounced in those with optimal serum 25(OH) Vit-D level (>40 nmol/l). To investigate possible factor interaction between Vit-D and VT on their anabolic bone effects, this in-vitro...

Objectives: This study aimed to evaluate detailed bone profiles during puberty for Chinese adolescents in Hong Kong using high-resolution peripheral quantitative computed tomography (HR-pQCT) and dual-energy x-ray absorptiometry (DXA).Methods: 333 healthy girls and 231 healthy boys (12–16-years-old) were recruited from secondary schools. Areal bone mineral density (aBMD) of bilateral femoral necks were measured by DXA while bone quality parameters w...

Adolescent idiopathic scoliosis (AIS) is associated with low bone mineral density (BMD) which has been reported to be an important prognostic factor for curve progression. In addition to BMD, high-resolution peripheral quantitative computed tomography (HR-pQCT) allows measurement of volumetric BMD, bone morphology, trabecular micro-architecture, and evaluation with structure model index (SMI) and finite element analysis (FEA) for mechanical property assessment. The aim of this...

Objectives: Vitamin D is essential for bone modeling/remodeling but the relationship between vitamin D status, bone mineral density (BMD) and bone quality parameters remains controversial especially in adolescent population. The aims of this study wase to evaluate the vitamin D status and its correlation with BMD and bone quality parameters among adolescent girls in Hong Kong where information is lacking.Methods: 156 adolescent girls (11–15 years ol...

Introduction and objective: Adolescent idiopathic scoliosis (AIS) is a three-dimensional spinal deformity with lateral curvature of ≧10 degree measured by Cobb angle. Previous studies reported that ~30% of female AIS patients had systemic osteopenia which could persist beyond skeletal maturity and that was one of the important prognostic factors. The aim of this study is to investigate the incremental prognostic value of osteopenia on curve progression in AIS as defined...

Objectives: AIS is a prevalent three-dimensional spinal deformity associated with low bone mass which has been reported to be a significant prognostic factor for curve progression in AIS. If left untreated, low bone mass in AIS could persist into adulthood thus leading to subsequent health problems. This study aimed at evaluating the therapeutic effect of oral calcium plus Vit-D supplementation for low bone mass in skeletally immature AIS girls.Methods: ...