Searchable abstracts of presentations at key conferences on calcified tissues

ba0002p88 | (1) | ICCBH2013

Children and adolescents with cystic fibrosis have normal volumetric BMD and geometry at the radius, but low muscle area at the forearm

Soucek Ondrej , Lebl Jan , Skalicka Veronika , Zemkova Dana , Sumnik Zdenek

Objectives: While studies in adults with cystic fibrosis (CF) showed increased fracture risk and decreased bone mineral density (BMD), the results of the pediatric studies have been contradictory. Our aims were to assess volumetric BMD, bone geometry and the muscle–bone relation at the forearm in children with CF using peripheral quantitative CT (pQCT), and to correlate these bone parameters to pulmonary function.Methods: Fifty-three patients with C...

ba0004p149 | (1) | ICCBH2015

Trabecular bone density decreased during 6 year observation in girls with Turner syndrome, but was not associated with fracture history

Soucek Ondrej , Sumnik Zdenek , Snajderova Marta , Kolouskova Stanislava , Lebl Jan

Objectives: Increased fracture risk and decreased bone mineral density (BMD) have been demonstrated by several studies in Turner syndrome (TS). Affected females have short stature and present with primary amenorrhea. Good densitometric predictor of fractures and longitudinal data on BMD development in childhood and adolescence are still lacking.Patients and methods: Single tertiary care endocrinology center longitudinal study was performed. Peripheral qu...

ba0006p106 | (1) | ICCBH2017

Does growth hormone and estrogens prevent girls with Turner syndrome from increased fracture rates?

Soucek Ondrej , Hlavka Zdenek , Lebl Jan , Sumnik Zdenek

Objectives: Turner syndrome (TS) affects 1:2000 girls and is mainly characterised by short stature and ovarian failure. Increased fracture risk has been reported in historical cohorts of women with TS and it was linked to their decreased bone mineral density (BMD). Nowadays, girls with TS are treated with growth hormone and substituted with estrogens, of which role in optimal bone mass accretion has been confirmed. Whether increased fracture rate is still of concern in these p...

ba0003pp197 | Muscle, physical activity and bone | ECTS2014

Girls with Turner syndrome have normal muscle force but decreased muscle power

Soucek Ondrej , Lebl Jan , Matyskova Jana , Snajderova Marta , Kolouskova Stanislava , Pruhova Stepanka , Sumnik Zdenek

Background: Turner syndrome (TS) is associated with decreased bone mineral density and altered bone geometry, which is assumed a risk factor leading to increased fracture rate. Although hypogonadism or SHOX gene haploinsufficiency are the probable causes, the exact mechanism remains unclarified. Particularly, the muscle function as an important determinant of bone strength has yet not been focused on in TS.Objective: We tested the hypothesis that there i...

ba0007lb7 | (1) | ICCBH2019

Validation study of automated bone age assessment in 1285 children and adolescents aged 5 to 16 years

Maratova Klara , Zemkova Dana , Lebl Jan , Soucek Ondrej , Pruhova Stepanka , Kolouskova Stanislava , Snajderova Marta , Krasnicanova Hana , Sumnik Zdenek

Background: Skeletal maturation is the most reliable indicator of biological age in children and adolescents. The evaluation of hand and wrist X-Ray according to Tanner-Whitehouse (TW3) or Greulich-Pyle (GP) are the most commonly used methods for biological age assessment. Automated bone age assessment has recently become increasingly popular, however a large independent study comparing automated and manual evaluation of bone age is still missing. The aim of this study was to ...