Searchable abstracts of presentations at key conferences on calcified tissues

ba0005ni7 | Abstract Presentations | ECTS2016

Exposure to chronic stress induces bone loss via glucocorticoid signalling in osteoblasts

Henneicke Holger , Li Jing-Bao , Gasparini Sylvia J , Seibel Markus J , Zhou Hong

Chronic stress and depression are associated with alterations in the hypothalamic┬ľpituitary┬ľadrenal signalling cascade and considered a risk factor for bone loss and fractures. However, the mechanisms underlying the association between stress and poor bone health are unclear. Utilising a transgenic (tg) mouse model in which glucocorticoid signalling is selectively disrupted in mature osteoblasts and osteocytes (HSD2OB-tg mice), the current study examines t...

ba0005p491 | Steroid hormones and receptors | ECTS2016

Exposure to chronic stress induces bone loss via glucocorticoid signalling in osteoblasts

Henneicke Holger , Li Jing-Bao , Gasparini Sylvia J , Seibel Markus J , Zhou Hong

Chronic stress and depression are associated with alterations in the hypothalamic-pituitary-adrenal signalling cascade and considered a risk factor for bone loss and fractures. However, the mechanisms underlying the association between stress and poor bone health are unclear. Utilising a transgenic (tg) mouse model in which glucocorticoid signalling is selectively disrupted in mature osteoblasts and osteocytes (HSD2OB-tg mice), the current study examines the impact ...

ba0005p129 | Cancer and bone: basic, translational and clinical | ECTS2016

Vertebral fractures among breast cancer survivors in China

Hsieh Evelyn , Wang Qin , Zhang Renzhi , Niu Xin , Li Jing , Zhou Chunwu , Qiao Youlin , Xia Weibo , Fraenkel Liana , Insogna Karl , Smith Jennifer , Zhang Pin

Background: Women with breast cancer (BC) are at high risk for fracture due to the deleterious impact of BC therapies on bone. In China, BC survival is improving as screening and treatment programs expand, however no guidelines exist to prevent BC treatment-induced bone loss. We sought to evaluate the scope of this problem among BC survivors receiving care at a large cancer referral hospital in China.Methods: Women were invited to participate in this cro...