Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp84 | Bone development/growth and fracture repair | ECTS2013

Variations in osteotoxic effects of cadmium on femoral bone structure after different routes of exposure

Martiniakova Monika , Chovancova Hana , Omelka Radoslav , Bobonova Ivana , Toman Robert

Cadmium (Cd) is regarded as a risk factor for various bone diseases in humans and experimental animals. To compare effects of different routes of Cd administration on femoral bone structure, ten 4-month-old male Wistar rats (group A) were injected intraperitoneally with a single dose of 2 mg CdCl2/kg body weight and killed 36 h after Cd had been injected. Ten 1-month-old male rats (group B) were dosed with a daily Cd intake of 30 mg CdCl2/l in drinking wa...

ba0003pp196 | Genetics | ECTS2014

Association of methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) with clinical indicators of osteoporosis in postmenopausal Slovak women

Krajcovicova Vladimira , Durisova Jana , Galbavy Drahomir , Martiniakova Monika , Omelka Radoslav

Objective: The enzyme methylenetetrahydrofolate reductase (MTHFR) is known to play an important role in the removal of circulating homocysteine via the methionine cycle. C677T polymorphism is associated with higher plasma homocysteine levels, which could affect collagen maturation. The aim of the present study was to examine possible associations of C677T polymorphism in the MTHFR gene with a variability of femoral (F-BMD), spinal BMD (S-BMD) together with circulating...

ba0001pp276 | Genetics | ECTS2013

No association between the CYP1B1/Leu432Val polymorphism and osteoporosis-related traits in Slovak postmenopausal women

Omelka Radoslav , Krajcovicova Vladimira , Spankova Jana , Durisova Jana , Martiniakova Monika , Galbavy Drahomir , Bauerova Maria

It is well known that sex hormone deficiency leads to increased bone turnover and subsequent bone loss. The metabolism of estrogens involves, among others, oxidation (mainly hydroxylation) by CYPs. The aim of this study was to determine whether Leu432Val polymorphism in the CYP1B1 gene is present also in Slovak population and subsequently, if it is associated with femoral and spinal bone mineral density (FBMD and SBMD), bone remodeling markers and fracture incidence in this po...

ba0003pp43 | Bone development/growth and fracture repair | ECTS2014

Subchronic co-administration to cadmium, diazinon and selenium causes apparent symptoms of osteoporosis in adult male rats

Omelka Radoslav , Chovancova Hana , Bobonova Ivana , Formicki Grzegorz , Toman Robert , Martiniakova Monika

Osteoporosis, as a global public health concern, may be induced by various hazardous substances such as cadmium (Cd) and pesticide diazinon (DZN). Selenium (Se), an essential trace element, can adversely modify bone structure in higher concentrations. The current study was designed to investigate structural changes in femoral bone of adult male rats after simultaneous co-administration to Cd, DZN, and Se. A total of 20 male Wistar rats were randomly divided into two experiment...