Searchable abstracts of presentations at key conferences on calcified tissues

ba0004p21 | (1) | ICCBH2015

Efficacy of GH therapy in short patients affected hypochondroplasia

Nakano Yukako , Harada Daisuke , Kashiwagi Hiroko , Seino Yoshiki

Since 1997, GH therapy has been approved for skeletal disorders including ACH and HCH patients in Japan. The efficacy of GH therapy for short period has been reported in several study. However, few study about efficacy and safety of GH therapy for long term have been shown. The aim of our study is to examine that GH therapy for HCH patients is efficient and safe enough and improve final height and proportion.18HCH patients (11 males and seven females) wh...

ba0007oc23 | (1) | ICCBH2019

Effects of the FGF2 aptamer on growth plate cartilage development of achondroplasia patient-specific iPS cells in a xenograft model

Kimura Takeshi , Yasuda Kie , Nakano Yukako , Takeyari Shinji , Kitabatake Yasuji , Kubota Takuo , Miyoshi Yoko , Ozono Keiichi , Nonaka Yosuke , Fujiwara Masatoshi , Nakamura Yoshikazu

Objectives: Endochondral ossification in the growth plate cartilage (GPC) plays a crucial role in the determination of the length and shape of long bones. Many skeletal dysplasias are caused by GPC dysfunction, associated with short stature. We have already reported that human iPS cell-derived cartilage (hiPSC-Cart), when implanted into the subcutaneous spaces of the SCID mice for 4 weeks, formed skeletal tissue like GPC. This model could also recapitulate the pathology of FGF...

ba0007p61 | (1) | ICCBH2019

Biochemical and genetic analysis in patients with odontohypophosphatasia in Japan

Kubota Takuo , Ohata Yasuhisa , Ishihara Yasuki , Fujiwara Makoto , Takeyari Shinji , Yamamoto Kenichi , Nakano Yukako , Miyata Kei , Nakayama Hirofumi , Kitaoka Taichi , Okawa Rena , Nakano Kazuhiko , Akiyama Tomoyuki , Ozono Keiichi

Background: Hypophosphatasia (HPP) is characterized by defective mineralization of bone and/or teeth in the presence of low serum alkaline phosphatase (ALP) activity and caused by mutations in the ALPL gene encoding tissue-nonspecific ALP. Odontohypophosphatasia (odonto HPP) is the mildest form of hypophosphatasia and characterized by dental complications without abnormalities of the skeleton system.Objectives: We aimed to investigate biochemical and gen...