Searchable abstracts of presentations at key conferences on calcified tissues

ba0004op10 | (1) | ICCBH2015

Does degree of adiposity influence upper limb fracture site in children?

Moon Rebecca , Lim Adelynn , Farmer Megan , Segaran Avinash , Clarke Nicholas , Harvey Nicholas , Dennison Elaine , Cooper Cyrus , Davies Justin

Although it has been suggested that overweight and obese children have an increased risk of fracture, recent studies in post-menopausal women have shown that the relationship between obesity and fracture risk varies by fracture site. Thus, obesity is protective against wrist fractures but confers an increased risk of humeral fractures. There are no data to suggest whether this observation is also present in children. We therefore assessed whether adiposity and overweight/obesi...

ba0006is17 | (1) (1) | ICCBH2017

Factors influencing peak bone mass

Harvey Nicholas C

Peak bone mass is a major determinant of osteoporosis risk and subsequent fragility fractures in older age. There is a wide range of factors influencing peak bone mass, ranging from those acting very early in life, for example in utero and periconception, to those acting through childhood and adolescence into young adulthood. In this presentation I will give an overview of some overarching themes and principles of relevance to peak bone mass, using specific clinical scenarios ...

ba0006is17biog | (1) (1) | ICCBH2017

Factors influencing peak bone mass

Harvey Nicholas C

Biographical DetailsNicholas HarveyNicholas Harvey was appointed to a personal chair at the University of Southampton in 2015, and leads, with Professor Cooper and Professor Dennison, an MRC programme focused on the lifecourse epidemiology of bone and joint disease, as part of the MRC Lifecourse Epidemiology Unit. He is working to i) translate epide...

ba0006p152 | (1) | ICCBH2017

Seasonal variation in internet searches for vitamin D

Moon Rebecca , Curtis Elizabeth , Davies Justin , Cooper Cyrus , Harvey Nicholas

Objective: Over the last decade, there has been increasing scientific interest in vitamin D, and it is now advised that all pregnant women and infants should receive vitamin D supplementation. Despite of this, it is recognized that knowledge of vitamin D in the general public is limited. The internet is now an important source of health care information and analysis of internet search activity rates can provide information on disease epidemiology, health related behaviors and ...

ba0007p167 | (1) | ICCBH2019

Children's multivitamins do not contain sufficient vitamin D

Moon Rebecca , Curtis Elizabeth , Cooper Cyrus , Davies Justin , Harvey Nicholas

Objective: Public Health England recommends that children in the United Kingdom (UK) aged over 1 year should take a vitamin D supplement containing 400 IU/day. Commercially available children’s multivitamin and vitamin D supplements were surveyed to determine the vitamin D content.Methods: Multivitamins and vitamin D supplements marketed at children <12 years and sold by nine UK supermarkets and health supplement retailers were surveyed. The vit...

ba0003pp201 | Muscle, physical activity and bone | ECTS2014

Prevalence of ‘dysmobility syndrome' in community dwelling older adults: findings from the Hertfordshire Cohort Study

Clynes Michael , Edwards Mark , Gregson Celia , Buehring Bjoern , Harvey Nicholas , Dennison Elaine , Binkley Neil , Cooper Cyrus

Sarcopenia and osteoporosis are common in later life, often coexist, and increase the risk of adverse health outcomes such as disability, falls and fracture. Binkley and colleagues recently devised a score-based system for the diagnosis of ‘dysmobility syndrome’ in an attempt to combine adverse musculoskeletal phenotypes and indentify older individuals at particular risk. We applied these criteria to a larger cohort of participants from the Hertfordshire Cohort Study...

ba0006lb8 | (1) | ICCBH2017

Breech presentation is associated with neonatal and early childhood deficits in bone mass and size

Ireland Alex , Crozier Sarah , Heazell Alexander , Ward Kate , Godfrey Keith , Inskip Hazel , Cooper Cyrus , Harvey Nicholas

Animal studies suggest that fetal movements are key to healthy skeletal development, but evidence in humans is limited. Breech presentation occurs in 3% of term births and is associated with reduced fetal movement and higher incidence of hip dysplasias, but more general effects on bone development have not been explored.Offspring whole body bone outcomes were measured using dual-energy X-ray absorptiometry (DXA) at mean(SD) 6(5) days after birth in 993 i...

ba0007p22 | (1) | ICCBH2019

Tibia microarchitecture in children with recent fractures

Moon Rebecca , Gillespie Tom , Quiney Naomi , Cooper Cyrus , Harvey Nicholas , Davies Justin

Objectives: Children who fracture have lower bone mineral density (BMD) measured by dual energy X-ray absorptiometry (DXA) than children who do not sustain fractures, but there is little data on bone microarchitecture in relation to childhood fracture. We assessed tibia microarchitecture using high resolution peripheral quantitative computed tomography (HR-pQCT) in children with recent fracture and those without a history of fracture.Methods: Children ag...

ba0007p154 | (1) | ICCBH2019

Self-reported sedentary time is negatively associated with microarchitecture of the tibia

Moon Rebecca , Gillespie Tom , Quiney Naomi , Cooper Cyrus , Harvey Nicholas , Davies Justin

Objectives: Weight bearing physical activity (PA) is thought to be beneficial to bone mineral accrual in childhood, but the influence of PA and sedentary time on bone microarchitecture is less well described. We examined the relationships between self-reported PA and volumetric bone mineral density (vBMD) and bone microarchitecture at the distal tibia, assessed using high resolution peripheral quantitative computed tomography (HR-pQCT).Methods: Healthy c...

ba0002oc4 | Epidemiology | ICCBH2013

Maternal antenatal 25(OH)-vitamin D status is associated with offspring muscle strength at 4 years of age

Moon Rebecca , Sayer Avan A , Ntani Georgia , Davies Justin , Robinson Sian , Godfrey Keith , Inskip Hazel , Cooper Cyrus , Harvey Nicholas

Objectives: Serum 25(OH)-vitamin D (25(OH)D) concentration is known to influence muscle function in postnatal life. Maternal 25(OH)D status during pregnancy has been implicated in the fetal programming of bone and fat mass, but little is known about its role in determining offspring muscle development. We investigated the associations between maternal serum 25(OH)D concentration in pregnancy and offspring muscle mass and strength at 4 years.Materials and...