Searchable abstracts of presentations at key conferences on calcified tissues

ba0001cu1.3 | Clinical Update 1 | ECTS2013

Genetic determinants of serum sex steroids and bone health in males

Ohlsson Claes

Osteoporosis in men causes significant morbidity and mortality. Considerable progress has been made in understanding the pathophysiology and management of osteoporosis, though it remains under-diagnosed and under-treated, particularly in men. Osteoporosis is widely considered to be more prevalent in women, even though at least one-third of all osteoporotic fractures occur in men. A major difference between the male and the female skeleton is the larger bone dimensions in the m...

ba0005s3.1 | Microbiome and musculoskeletal health | ECTS2016

Gut microbiota and bone metabolism

Ohlsson Claes , Sjogren Klara

The gut microbiota (GM), the commensal bacteria living in our intestine, performs numerous useful functions, including modulating host metabolism and immune status. Our recent studies demonstrate that the GM is also a regulator of bone mass and we propose that the effect of the GM on bone mass is mediated via effects on the immune system, which in turn regulates osteoclastogenesis. A role of the GM in bone metabolism is further supported by studies demonstrating that antibioti...

ba0005oc6.4 | Development and differentiation (or Aging) | ECTS2016

Extranuclear effects of estrogen on cortical bone in males is dependent on estrogen receptor A activation function-1

Farman Helen , Wu Jianyao , Gustafsson Karin , Windahl Sara , Kim Sung , Katzenellenbogen John , Ohlsson Claes , Lagerquist Marie

Estradiol (E2) signaling via estrogen receptor alpha (ERα) is important for the male skeleton as demonstrated by ERα inactivation in both mice and man. ERα mediates estrogenic effects by translocating to the nucleus and there affects gene transcription, but some effects can also be mediated via extra-nuclear actions of the receptor by, e.g., triggering cytoplasmic signaling cascades. ERα contains various domains and the role of activation functio...

ba0005oc3.5 | Clinical trials, FGF-23 and focal osteoporosis | ECTS2016

Low serum iron is associated with high serum FGF23 in elderly men: the Swedish MrOS study

Lewerin Catharina , Ljunggren Osten , Nilsson-Ehle Herman , Karlsson Magnus K , Herlitz Hans , Lorentzon Mattias , Ohlsson Claes , Mellstrom Dan

Introduction: Fibroblast growth factor (FGF23) is a hormone derived from osteoblasts and osteocytes being involved in calcium and phosphate homeostasis, where serum iron (S-Fe) has been suggested as a potential mediator of FGF23 regulation. The aim was to determine whether iron status is a determinant of FGF23 in elderly men.Methods: The MrOS (osteoporotic fractures in men is a population based study of elderly men, in the Gothenburg part, (median age of...

ba0005p280 | Nutrition | ECTS2016

Effects of clinically relevant doses of vitamin A on bone in mice

Lionikaite Vikte , Gustafsson Karin , Westerlund Anna , Koskela Antti , Tukkanen Juha , Conaway H Herschel , Ohlsson Claes , Henning Petra , Lerner Ulf

Excess vitamin A has been associated with decreased cortical bone thickness and increased fracture risk. While most studies in rodents have been done using very high doses of vitamin A for a few days, we here investigate how clinically relevant doses of vitamin A, calculated from the Recommended Daily Allowance (RDA) in humans, affects the bone phenotype in mice after longer exposure.C57BL/6 mice were fed either a control diet (15 IU/g retinyl acetate), ...

ba0005ht2 | (1) | ECTS2016

Mice lacking estrogen receptor α in hypothalamic POMC neurons display enhanced estrogenic response on cortical bone mass

Farman Helen , Windahl Sara , Clegg Deborah , Xie Shang Kui , Westberg Lars , Isaksson Hanna , Egecioglu Emil , Schele Erik , Johnsson John Olov , Tuukkanen Juha , Hahner Lisa , Zehr Jordan , Lagerquist Marie , Ohlsson Claes

Estrogens are important regulators of bone mass and exert their physiological effects on bone mainly via estrogen receptor α (ERα). Central ERα has been reported to exert an inhibitory role on bone mass. ERα is widely distributed in the brain with a high expression in the arcuate nucleus (ARC) and the ventral medial nucleus (VMN) in the hypothalamus. Here, we tested the hypothesis that ERα in hypothalamic pro-opiomelanocortin (POMC) neurons, located in...

ba0005p490 | Steroid hormones and receptors | ECTS2016

Phosphorylation of S122 in ERα is important for the skeletal response to estrogen treatment

Gustafsson Karin , Farman Helen , Lionikaite Vikte , Wu Jianyao , Henning Petra , Andersson Annica , Islander Ulrika , Bernardi Angelina , Windahl Sara , Skrtic Sofia , Sjogren Klara , Koskela Antti , Tuukkanen Juha , Krust Andree , Chambon Pierre , Ohlsson Claes , Lagerquist Marie

It is well established that estrogen, mainly via estrogen receptor alpha (ERα), has positive effects on bone, but estrogen is not considered as a treatment option against osteoporosis due to negative side-effects in other tissues. ERα is widely subjected to posttranslational modifications (PTMs), which can affect cellular responses to estrogen in a tissue specific manner by influencing the function of ERα and its interactions with other proteins. The in vivo...

ba0001pp279 | Genetics | ECTS2013

Genome-wide association study meta-analysis identifies the SOAT1/AXDND1 locus to be associated with hip and forearm fracture risk

Pettersson-Kymmer Ulrika , Lacroix Andrea , Eriksson Joel , Bergstrom Ulrica , Melin Beatrice , Wibom Carl , Vandenput Liesbeth , Rajaraman Preetha , Hartge Patricia , Chanock Stephen , Hallmans Goran , Duggan David , Kooperberg Charles , Handelman Samuel , Aragaki Aaron , Nethander Maria , Uitterlinden Andre , Rivadeneira Fernando , Jackson Rebecca , Ohlsson Claes

Hip and forearm fractures are the two clinically most important non-vertebral fractures. Twin studies have demonstrated a high heritability of these fractures and the heritable component of fracture risk is largely independent of BMD.To identify common genetic variants associated with hip and forearm fractures, we performed a genome-wide association study (GWAS ~ 2.5 million SNPs) meta-analysis of two large fracture data sets within the well-characterize...