Searchable abstracts of presentations at key conferences on calcified tissues

ba0004p23 | (1) | ICCBH2015

Relationship of IGF1 and bone parameters in 7--16 year old apparently healthy Indian children

Kajale Neha , Ekbote Veena , Palande Sonal , Shilvant Dhanashri , Mandlik Rubina , Khadilkar Vaman , Mughal Zulf , Khadilkar Anuradha

Objective: GH through IGF1 plays an important role in both bone growth and mineralization. This cross-sectional study was carried out to evaluate the relationship between serum IGF1 concentrations and dual energy X-ray (DXA) measured total body less head (TB) bone area (BA), lean body mass (LBM) and bone mineral content (BMC).Methods: One hundred and nineteen children (B=70, age =7.3–15.6 years) were studied for their anthropometric paramet...

ba0007oc2 | (1) | ICCBH2019

Adolescent pregnancy and bone density in premenopausal women

Palande Sonal , Padidela Raja , Khadilkar Anuradha , Mughal Zulf , Chiplonkar Shashi , Khadilkar Vaman , Chauthmal Sujata , Kajale Neha

Objectives: High prevalence (20%) of adolescent pregnancy (AP) (1) is observed in India. Reports suggest that pregnancy during adolescence may have deleterious effects on peak bone mass (2). Few reports have described the long-term effects of history of AP on bone. The objective of this study was to compare bone density and geometry of premenopausal women having delivered first child during adolescence (before age of 19 years) or after 19 years.Methods: ...

ba0007p41 | (1) | ICCBH2019

Increased prevalence of fractures in poorly chelated children with beta thalassemia

Palande Sonal , Ekbote Veena , Padidela Raja , Mughal Zulf , Khadilkar Anuradha , Khadilkar Vaman , Kariki Eleni , Crabtree Nicola

Objectives: Patients with beta Thalassemia have been reported to have low bone mass; poorly chelated patients are likely to be at an even higher risk. Pubertal delay, hypogonadism, and reduced physical activity and sunlight exposure are likely to be additional contributors to poor bone health and increased fracture risk. The objective of our study was to assess the prevalence of fractures in Indian underprivileged, poorly chelated thalassaemic children.M...

ba0007p87 | (1) | ICCBH2019

Assessment of bone density by DXA in poorly controlled children with β-Thalassemia: Correction for hepatic iron - overloadby manual analysis

Palande Sonal , Ekbote Veena , Padidela Raja , Mughal Zulf , Khadilkar Anuradha , Khadilkar Vaman , Crabtree Nicola

Objectives: Beta thalassemia major (BTM) is characterized by anemia and iron overload, especially in children with inadequate chelation therapy. Dual energy x-ray absorptiometry software (DXA) may misanalyse bone measurements due to iron overload/deposition in organs such as the liver. Our objective was to study difference between the anterio-posterior spine measurements of bone mineral content (BMC), area (BA) and density (BMD) in non-chelated beta thalassaemia children with ...

ba0007p158 | (1) | ICCBH2019

Association of grip strength and body composition in Indian boys and girls

Palande Sonal , Ekbote Veena , Chiplonkar Shashi , Vispute Smruti , Khadilkar Vaman , Khadilkar Anuradha

Objectives: Association of grip strength (GS) with anthropometric parameters has been reported. Our objective was to assess grip strength in 6 to 18-year-old healthy Indian children (urban and rural) and study the association of GS with body composition.Methods: This was a part of a multicenter, cross-sectional, observational school-based study; multi-stage stratified random sampling was carried out and children (n=1980) from various urban (...

ba0007p159 | (1) | ICCBH2019

Determinants of muscle function in 6 to 11 year old rural Indian children

Palande Sonal , Ekbote Veena , Chauthmal Sujata , Vispute Smruti , Chiplonkar Shashi , Khadilkar Vaman , Khadilkar Anuradha

Objective: Children in rural areas have inadequate nutritional intake, hence their muscle function may be compromised. The objective of this study was to study the determinants of muscle function in rural Indian school going children.Methods: We cross sectionally studied 232 prepubertal school going children (106 girls) aged 6–11 years, from 2 different villages in rural area around Pune city in July 2018. Height, weight, body composition (bioelectr...

ba0007p160 | (1) | ICCBH2019

Assessment of muscle mass and function in Indian children with type 1 diabetes

Palande Sonal , Lohiya Nikhil , Ekbote Veena , Khadilkar Anuradha , Khadilkar Vaman , Chiplonkar Shashi

Objective: Type 1 diabetes (T1D) in one of the commonest chronic childhood disorders; poor muscle function and sarcopenia has been reported among T1D in adults. Reports on the impairment of muscle function are scarce in children. Our objective was to assess muscle mass and function in children with diabetes and study association of muscle mass and function with control of blood glucose (as measured by HbA1C) and disease duration.Methodology: This was a c...

ba0007p174 | (1) | ICCBH2019

Supplementation of children with type 1 diabetes with milk or pharmacological calcium for improving bone health – a randomized controlled trial

Palande Sonal , Lohiya Nikhil , Mughal Zulf , Padidela Raja , Chiplonkar Shashi , Ekbote Veena , Khadilkar Anuradha , Khadilkar Vaman

Objective: Using DXA, we have previously reported that children with type 1 diabetes (T1D) had short and thin bones (Bone, 2015). Calcium supplementation promotes bone mass accrual with sustained benefit observed using milk/milk-based calcium but not calcium salts. To investigate effect of 1-year supplementation with milk vs pharmacological calcium salt on bone mineral density (BMD) and geometryin Indian underprivileged children with T1D. Both groups received vitamin D supplem...

ba0007p89 | (1) | ICCBH2019

Use of DXA and pQCT measurements to screen for fracture risk in 3 to 18 year old poorly chelated thalassaemic children

Palande Sonal , Ekbote Veena , Chilplonkar Shashi , Chauthmal Sujata , Khadilkar Vaman , Ramanan Vijay , Khadilkar Anuradha , Padidela Raja , Mughal Zulf , Crabtree Nicola

Objectives: Low bone mineral density has been reported in children with beta thalassemia major, they also have increased propensity to fracture. We have studied DXA and pQCT variables in poorly chelated 3 to 18 year old thalassaemic patients and their relationship with fractures in this population.Methods: We studied 167, 3 to 18 year old children (Girls 72) with beta thalassemia major. Bone measurements were performed by GE iDXA (Lumbar Spine, Total bod...

ba0007p155 | (1) | ICCBH2019

Gender specific paediatric reference data for muscle function parameters assessed using jumping mechanography

Palande Sonal , Ekbote Veena , Chiplonkar Shashi , Padidela Raja , Mughal Zulf , Vispute Smruti , Rawer Rainer , Khadilkar Anuradha , Khadilkar Vaman

Objective: Bone adapts to mechanical stimuli by increasing its mass and changing geometry; muscles are the stimulators for this change as they induce forces through contractions. Thus, bone strength is driven by muscle function. Research has shown that muscle mass and muscle function may not be proportional and hence analysing muscle function becomes of crucial importance. Here we propose to establish gender specific paediatric reference data for muscle function parameters ass...