Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp85 | Bone development/growth and fracture repair | ECTS2014

The impact on calcium metabolism when replacing intact PTH with teriparatide treatment in patients with hypoparathyroidism

Andersen Lise Sofie , Sikjaer Tanja , Rejnmark Lars

PTH replacement therapy in hypoparathyroidism (hypoPT) has become more accepted after proving successful in several clinical studies. Intact PTH (PTH1–84) was in 2012 withdrawn, leaving teriparatide (PTH1–34) the only therapeutic option available.All patients with postoperative HypoPT who changed medication from PTH1–84 (100 μg) to PTH1–34 (20 μg), after at least 12 months of conve...

ba0005p439 | Other diseases of bone and mineral metabolism | ECTS2016

Quality of life and psysical activicy in patients with non-surgical hypoparathyroidism and pseudohypoparathyroidism

Underbjerg Line , Sikjaer Tanja , Rejnmark Lars

Background: Non-surgical hypoparathyroidism (NS-HypoPT) and pseudohypoparathyroidism (Ps-HypoPT) are both rare diseases, with a prevalence of 2/100.000 and 1/100.000, respectively.Studies on Quality of Life, QoL, are sparse, but studies have shown an increased risk of fatigue and depression.Methods: Using the Danish version of SF36v2 and WHO-5 Well Being Index, we investigated the physical and mental QoL among patients with NS-Hypo...

ba0001pp112 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2013

Plasma triiodothyronine levels are positively associated with BMD and bone strength: a cross-sectional study

Moser Emil , Sikjaer Tanja , Mosekilde Leif , Rejnmark Lars

In previous studies, discrepant effects of TSH and thyroid hormones on bone have been reported. While low TSH and high thyroxine (T4) levels increase bone turnover, a recent study suggested a positive association between triiodothyronine (T3) levels and mineral deposition in bone. No data are available on bone architecture and strength in relation to thyroid status.Aim: Using a cross-sectional design, we determined whether bone dens...

ba0001pp464 | Other diseases of bone and mineral metabolism | ECTS2013

Effects of add-on parathyroid hormone (PTH(1-84)) substitution therapy in hypoparathyroidism: results from 2.5 years of PTH treatment

Sikjaer Tanja , Moser Emil , Rolighed Lars , Mosekilde Leif , Rejnmark Lars

Conventional treatment of hypoparathyroidism with calcium and active vitamin D analogues causes a high renal calcium excretion and over-mineralized bone.We studied 62 patients with hypoPT randomized to 6 months of treatment with either parathyroid hormone (PTH(1-84)) 100 μg/d s.c. or similar placebo, administered as an add-on therapy. Forty-two of the patients had follow-up test performed after 2.5 years; 9 patients had continued daily PTH treatment...

ba0001pp465 | Other diseases of bone and mineral metabolism | ECTS2013

Post surgical hypoparathyroidism and the risk of fractures

Underbjerg Line , Sikjaer Tanja , Mosekilde Leif , Rejnmark Lars

Background: Hypoparathyroidism (HypoPT) is a rare disease, characterized by low plasma levels of Parathyroid hormone and calcium. Furthermore it is characterized by high BMD and very low bone turnover.Aim: We studied risk of fracture in patients with postsurgical HypoPT due to non-malignant diseases compared with an age- and gender-matched control group.Method: We performed a controlled cohort study. Patients diagnosed with HypoPT ...

ba0003pp233 | Osteoporosis: evaluation and imaging | ECTS2014

aBMD at the hip measured by DXA overestimate cortical vBMD assesed by QCT scans

Amstrup Anne Kristine , Sikjaer Tanja , Mosekilde Leif , Rejnmark Lars

Background: DXA scan has for many years been gold standard when analyzing areal bone mineral density (aBMD) in osteoporotic patients. Risk of fractures increases as aBMD declines. However, although risk of fracture is highest in patients with osteoporosis, it is well known that the majority of fragility fractures actually occur in patients with osteopenia rather than osteoporosis. As aBMD is a projected two dimensional imaging technique it does not differentiate between cortic...

ba0003pp210 | Muscle, physical activity and bone | ECTS2014

No beneficial effects of vitamin D supplementation in muscle function or quality of life in primary hyperparathyroidism: results from a randomized controlled trial

Rolighed Lars , Rejnmark Lars , Sikjaer Tanja , Heickendorff Lene , Vestergaard Peter , Mosekilde Leif , Christiansen Peer

Context: Impairment of muscle function and strength in patients with primary hyperparathyroidism (PHPT) is rarely addressed although decreased muscle function may contribute to increased fracture risk in PHPT.Objective: We aimed to assess changes in muscle strength, muscle function, postural balance, quality of life (QoL), and well-being during treatment with vitamin D or placebo before and after parathyroidectomy (PTX) in PHPT patients.<p class="abs...

ba0005p429 | Other diseases of bone and mineral metabolism | ECTS2016

Impaired quality of life and muscle function in patients with hypoparathyroidism/hypothyroidism compared with only hypothyroidism and controls

Sikjaer Tanja , Moser Emil , Rolighed Lars , Underbjerg Line , Bislev Lise , Mosekilde Leif , Rejnmark Lars

Total thyroidectomy causes postsurgical hypothyroidism (HypoT). Besides HypoT, patients may also develop hypoparathyroidism (HypoPT).The aim of the study was to assess Quality of Life (QoL), muscle function, and bone indices in patients with postsurgical hypothyroidism and hypoparathyroidism (HypoT+PT) as compared to patients with postsurgical HypoT and healthy controls.Age and gender matched patients on treatment for HypoT+PT and ...

ba0001pp286 | Muscle, physical activity and bone | ECTS2013

Muscle function and quality of life in primary hyperparathyroidism

Rolighed Lars , Amstrup Anne Kristine , Jakobsen Niels Frederik Breum , Sikjaer Tanja , Mosekilde Leif , Christiansen Peer , Rejnmark Lars

Introduction: In spite of the frequent encounter of ‘asymptomatic’ primary hyperparathyroidism (PHPT), the patients often describe various relevant improvements postoperatively suggesting a subclinical biological effect of elevated PTH or hypercalcaemia.Materials and methods: To evaluate muscle function, postural stability, and quality of life (QoL) in untreated PHPT, we assessed maximal isometric muscle strength in upper and lower extremities,...