Searchable abstracts of presentations at key conferences on calcified tissues

ba0001niw1 | (1) | ECTS2013

Genomics and proteomics as emerging technologies in bone research

Uitterlinden Andre G

The quantum leaps in scientific progress have frequently come from technological innovations, which can be referred to as the technology push. In the life-sciences this has been exemplified by the emergence of all kinds of ‘omics’ technologies reflecting the capacity to analyse complete and complex molecular mixtures in a hypothesis-free approach, also known as ‘fishing expeditions’ by more sceptical fellow scientists. Such approaches have been developed fo...

ba0002oc3 | Epidemiology | ICCBH2013

Pediatric differences in bone mineral density according to ethnic background in children: The Generation R Study

Medina-Gomez Carolina , Heppe Denise , Hofman Albert , Uitterlinden Andre G , Jaddoe Vincent , Rivadeneira Fernando

Aim: Differences in fracture risk between ethnic groups have been documented. The basis for these differences is yet incomplete and the age at what ethnic differences appear is uncertain. Assessment of bone health in pediatric populations could bring insights on factors compromising bone accrual. We describe here differences in total body bone mineral density (TB-BMD) in a unique setting of children of the same age, measured with the same device (iDXA) different ethnic backgro...

ba0003oc6.1 | Osteoporosis treatment and the effects of physical activity | ECTS2014

Sex differences in bone acquisition of pre-pubertal children are consequence of differential responsiveness to mechanical loading

Medina-Gomez Carolina , Heppe Denise H.M. , Kruithof Claudia J. , Hofman Albert , Uitterlinden Andre G. , Jaddoe Vincent V.W. , Rivadeneira Fernando

Aim: Lean mass is a strong determinant of bone structure, particularly during growth and development. We sought to determine if there are sex differences in bone acquisition in pre-pubertal children and the potential relation with skeletal loading.Methods: This study included 3602 children (50.7% girls) whose total body BMD and hip scans were measured on the same iDXA devise (GE-Lunar) at 6 years of age. Hip scans underwent hip structural analysis (HSA) ...

ba0006oc13 | (1) | ICCBH2017

Enterococccus faecium abundance in gut microbiome is associated with higher bone mineral density in school age children

Medina-Gomez Carolina , Radjabzadeh Djawad , Boer Cindy G. , Van Meurs Joyce , Kraaij Robert , Uitterlinden Andre G , Rivadeneira Fernando

Aim: Human gut microbiota is an important determinant of health and disease. Discoveries from recent microbiome studies have been postulated as actionable targets to treat malnutrition, diabetes, obesity among other conditions. The role of the gut microbiome on the development of the human musculoskeletal system is yet to be established. The aim of our study was to investigate the association between bacterial operational taxonomic units (OTUs) of the gut in relation to bone m...

ba0006p015 | (1) | ICCBH2017

Structural geometry of bones is prominently associated with risk of fracture in children

Medina-Gomez Carolina , Grgic Olja , Shevroja Enisa , Trajanoska Katerina , Uitterlinden Andre G , Jaddoe Vincent W , Beck Tom J , Rivadeneira Fernando

Background: Low total body BMD (TB-BMD) is an established risk factor for fractures in healthy children. However, bone strength depends not only on bone mass and density, but also on the structural geometry of bones. Hip structural analysis (HSA) is a technique applied on hip DXA scans to calculate several bone geometry parameters. The aim of our study was to evaluate other bone geometrical parameters that can constitute determinants of fracture risk. Specifically, we examined...

ba0002oc7 | Biology | ICCBH2013

The PPP6R3/LRP5 locus influences lean mass in children of different ethnic background and highlights pleiotropic effects and muscle–bone interactions

Medina-Gomez Carolina , Heppe Denise , Estrada Karol , Hofman Albert , Hsu Yi-Hsiang , Karasik David , Jaddoe Vincent , Zillikens M Carola , Uitterlinden Andre G , Rivadeneira Fernando

Aim: Lean and bone mass have considerably high phenotypic and genetic correlations with a shared heritability estimate ranging between 30 and 40% in adults. A genome-wide association study (GWAS) on total body lean mass and a bivariate GWAS on lean mass and BMD were ran in a cohort of children to identify genes with pleiotropic effects on muscle mass and peak bone mass attainment.Methods: Subjects are part of the Generation R study, a prospective multiet...

ba0005p372 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Sex hormone-binding globulin is associated with markers of vertebral fracture and vertebral fracture risk

Koromani Fjorda , Muka Taulant , Oei Ling , Zillikens Carola , Hofman Albert , Uitterlinden Andre G , Oei Edwin , Hans Didier , Franco Oscar H , Rivadeneira Fernando

Background: The relation between sex hormone-binding globulin (SHBG) and vertebral fracture (VFx) is unclear.Aim: To examine whether SHBG is associated with bone mineral density at lumbar spine (LS-BMD), trabecular bone score (TBS) and prevalent VFx.Methods: Data of 6224 men and women participants in the third visit of the first cohort (I-3) and the first visit of the second cohort (II-1) of a prospective population based cohort, w...

ba0005p373 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

The association between diabetes, trabecular bone score, bone mineral density and vertebral fractures

Koromani Fjorda , Muka Taulant , Oei Ling , Zillikens Carola , Hofman Albert , Franco Oscar H , Uitterlinden Andre G , Oei Edwin , Hans Didier , Rivadeneira Fernando

Background: Fracture risk is increased in Type 2 diabetes (T2D) individuals. Bone mineral density (BMD) is inversely associated with fracture risk but paradoxically high in T2D individuals. Trabecular bone score (TBS) reflects bone microarchitecture and predicts fracture risk.Objective: We aimed to compare mean lumbar spine TBS (LS-TBS) and lumbar spine BMD (LS-BMD) values, across individuals with and without i) vertebral fracture (VFx), ii) T2D; and iii...

ba0005p374 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Long term follow-up of fracture incidence and fracture prediction from bone mineral density

Trajanoska Katerina , de Jonge Ester A L , Kieboom Brenda C T , Mulder Marlies , Stricker Bruno H C , Franco Oscar H , Uitterlinden Andre G , Rivadeneira Fernando

Introduction: Due to the ‘greying’ of (industrialized) societies the incidence of osteoporosis and fragility fractures is expected to be increasing. Our aim was to investigate in an elderly population if the incidence of non-vertebral fractures (overall and site specific) has changed after a longer follow-up, and its relation with osteoporosis or osteopenia assessed by bone mineral density (BMD) at baseline.Methods: Incident non-vertebral fract...