Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p479 | Paediatric bone disease | ECTS2016

Increased bone resorption markers in young patients with inflammatory bowel disease

Laakso Saila , Valta Helena , Verkasalo Matti , Viljakainen Heli , Makitie Outi

Children and adolescents with inflammatory bowel disease (IBD) have defects in bone mineral density (BMD) and bone structure that do not completely normalize with clinical remission.The objective of the study was to determine bone turnover marker (BTM) concentrations and factors behind altered bone metabolism in a case-control setting.We measured the bone formation marker PINP and bone resorption markers CTX and TRACP5b in 42 adole...

ba0001oc3.3 | Osteoporosis pathophysiology and genetics | ECTS2013

Distinct relationships of intramuscular and subcutaneous fat with cortical bone: findings from a cross sectional study of young adult males and females

Deere Kevin , Sayers Adrian , Viljakainen Heli , Lawlor Debbie , Sattar Naveed , Kemp John , Fraser William , Tobias Jon

Introduction: Intracellular fat within muscle and visceral tissue has been suggested to adversely influence bone development.Design: We aimed to compare associations between intramuscular and subcutaneous fat and cortical bone outcomes in young adults, in cross-sectional analyses based on the Avon Longitudinal Study of Parents and Children.Method: Data were collected from a research clinic conducted at 17 years of age. Intramuscula...

ba0001pp113 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2013

Lower bone turnover in obesity: is there a link to energy metabolism?

Viljakainen Heli , Ivaska Kaisa K , Lipsanen-Nyman Marita , Saukkonen Tero , Andersson Sture , Laitinen Kalevi , Makitie Outi

Background: Observations in rodents suggest that osteocalcin (OC) participates in glucose metabolism. Data from human studies are inconclusive and it remains unclear whether OC is simply a marker of bone turnover (BTM) or if it also mediates interactions between the skeleton and glucose homeostasis. This study determined the responses of BTMs, including OC, to oral glucose tolerance test (OGTT) in obese and normal-weight subjects.Materials and methods: P...

ba0002p46 | (1) | ICCBH2013

Interactions of adipokines and bone metabolism in patients with severe juvenile idiopathic arthritis

Markula-Patjas Kati , Ivaska Kaisa , Pekkinen Minna , Andersson Sture , Viljakainen Heli , Makitie Outi

Objectives: The skeleton and adipose tissue interact. Our aim was to evaluate the interactions between adipokines and bone metabolism, and their association with disease-related factors in patients with severe juvenile idiopathic arthritis (JIA).Methods: The study included 49 patients (median age 14.8 years, median disease duration 10.2 years) with refractory polyarticular JIA and 89 sex- and age-matched healthy controls. The subjects underwent clinical ...

ba0005p272 | Nutrition | ECTS2016

Obese young adults exhibit lower total and lower free serum 25-hydroxycholecalciferol in a randomized vitamin D intervention

Holmlund-Suila Elisa , Pekkinen Minna , Ivaska Kaisa K. , Andersson Sture , Makitie Outi , Viljakainen Heli

Objective: Although obesity is a risk factor for vitamin D insufficiency, its impact on vitamin D-binding protein (DBP) concentration, and thereby possibly also on free 25OHD, is less well known. Our aim was to compare total and free serum 25OHD, and DBP concentrations between obese and normal-weight young adults at baseline, and their responses to cholecalciferol supplementation.Design: A 12 weeks’ randomized, double-blinded clinical trial.<p c...

ba0001pp352 | Osteoporosis: pathophysiology and epidemiology | ECTS2013

The relationship between urban–rural migration and bone mineral density in an urban–rural adult population: cross sectional findings from the hyderabad indian migration study

Viljakainen Heli , Ben-Shlomo Yoav , Kinra Sanjay , Ebrahim Shah , Kuper Hannah , Radhakrishna KV , Kulkarni Bharathi , Tobias Jon

Rural to urban migration is associated with adverse metabolic consequences, but its effect on osteoporosis risk is unclear. We investigated associations between rural to urban migration and bone mineral density (BMD) after accounting for changes in body composition. A cross sectional analysis was performed of rural–urban migrants (RUM) matched with rural non-migrated (RNM) siblings, plus a separate sample of urban-non-migrants (UNM). Participants (n=764, 54% male...

ba0006p020 | (1) | ICCBH2017

Age at onset of walking affects bone mineral content in early childhood

Valkama Saara , Viljakainen Heli , Holmlund-Suila Elisa , Rosendahl Jenni , Hauta-alus Helena , Enlund-Cerullo Maria , Helve Otto , Andersson Sture , Makitie Outi

Objectives: The aim of this study was to evaluate the association between the age at onset of walking and bone mineral content (BMC) in healthy 2-year-old children participating in the Vitamin D in Infants Trial (VIDI).Methods: Altogether 253 children (120 girls, 133 boys) with a daily vitamin D3 intake of 10 μg and a sufficient serum 25-hydroxyvitamin D (25-OHD) concentration (>50 nmol/l) were included in the analysis. BMC was measur...

ba0006p027 | (1) | ICCBH2017

Sex and iron modify fibroblast growth factor 23 concentrations in 1-year-old children

Holmlund-Suila Elisa , Enlund-Cerullo Maria , Valkama Saara , Hauta-alus Helena , Rosendahl Jenni , Helve Otto , Viljakainen Heli , Andersson Sture , Makitie Outi

Objectives: The regulation of fibroblast growth factor 23 (FGF23) metabolism during infancy is inadequately characterized. We previously observed a distinct sex difference in intact FGF23 at 3 months of age. In this study we aimed to further examine the role of sex and iron status in FGF23 metabolism in 1-year-old children.Methods: This was a cross-sectional study including 731 1-year-old Caucasian children participating the Vitamin D intervention in inf...