Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p328 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Use of proton pump inhibitors and hip re-fractures among Austrian hip fracture patients

Brozek Wolfgang , Reichardt Berthold , Zwerina Jochen , Peter Dimai Hans , Klaushofer Klaus , Zwettler Elisabeth

We retrospectively analyzed the incidence of hip re-fractures in Austrian hip fracture patients devoid of anti-osteoporotic drug treatment, taking vs not taking proton pump inhibitors (PPIs).For 31,668 patients ≥50 years sustaining a hip fracture in Austria between July 2008 and December 2010, information on hip re-fractures with follow-up until June 2011 and on filed prescriptions of PPIs and anti-osteoporotic drugs between July 2007 and June 2011...

ba0007oc3 | (1) | ICCBH2019

Osteocyte lacunae characteristics in healthy children

Blouin Stephane , Hartmann Markus A , Klaushofer Klaus , Glorieux Francis H. , Rauch Frank , Zwerina Jochen , Roschger Paul

Objectives: Osteocytes play a major role in bone metabolism as mechanosensors, key regulators of osteoblast and osteoclast activity and of the mineral homeostasis. Therefore the assessment of osteocytes characteristics is important to understand bone pathology. We propose to study indirectly the osteocytes by performing quantitative backscattered electron imaging to quantify the sectioned osteocyte lacunae density and size in 2D on bone samples.Methods: ...

ba0007p169 | (1) | ICCBH2019

Rescue diet restores bone matrix mineralization in mice with a non-functioning vitamin D receptor

Misof Barbara , Blouin Stephane , Hartmann Markus , Hofstaetter Jochen , Klaushofer Klaus , Zwerina Jochen , Roschger Paul , Erben Reinhold

Objectives: Mice with a non-functioning vitamin D receptor (VDR mutants) develop severe secondary hyperparathyroidism, which can be rescued by a diet enriched with calcium, phosphate and lactose. In this work, we studied the effects of a low calcium challenge (CD), normal calcium (ND) and a calcium enriched rescue diet (RD) on the bone mineralization density distribution (BMDD) and osteocyte lacunae sections (OLS) in these mice.Methods: BMDD and OLS were...

ba0004p199 | (1) | ICCBH2015

LRP5-associated high bone mass disorder: novel familial mutation in LRP5 and investigation of bone mineralization density distribution (BMDD)

Roetzer Katharina M , Uyanik Goekhan , Brehm Attila , Zwerina Jochen , Zandieh Shahin , Czech Thomas , Roschger Paul , Klaushofer Klaus

Mutations in LRP5 cause a variety of phenotypes, including high bone mass and low bone mass disorders. In patients with high bone mass, different heterozygous mutations have been described, all of them clustering in a region including the binding pocket for DKK1 and sclerostin. The pathogenic mechanism is thought to be a gain-of-function mediated by an impaired inhibition of the canonical Wnt signalling pathway, thereby leading to increased bone modelling.<p class="abstext...