Osteoporosis: pathophysiology and epidemiology

ba0005p324 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Serum 25-hydroxyvitamin D, parathyroid hormone, and bone mineral density in Korean perimenopausal women

Introduction: This study aims to assess 25-hydroxyvitamin D25(OH)Dstatus in perimenopausal women to analyze its relationships with serum PTH levels and bone mineral density (BMD).Methods: A total of 102 individuals who visited to climacteric clinic in Sanggye paik hospital participated in the study. Serum 25(OH)D and intact parathyroid hormone (PTH) were measured. BMD was determined by dual x-ray absorptiometry (DXA) at lumbar spine, femoral ...

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ba0005p325 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Bone mineral density of lumbar spine and femur in patients with gynaecologic cancer

Kim Heungyeol

Objective: To compare the bone mineral density (BMD) of the lumbar spine and femur in postmenopausal women with cervical and endometrial cancer without bone metastasis with that in normal control postmenopausal women.Methods: We retrospectively analysed the BMD of the lumbar spine and femur using dual-energy X-ray absorptiometry in 130 patients with cervical cancer, 68 patients with endometrial cancer, and 225 healthy controls.Resu...

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ba0005p326 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Calcium and vitamin D supplementations: 2015 position statement of the Korean society for bone and mineral research

Ju Lee Han

Calcium and vitamin D are essential components for bone health, thus calcium and vitamin D supplementation is an important strategy in the management of osteoporosis.However, the benefit of calcium and vitamin D supplementation on bone health is still controversial. Moreover, potentially harmful effects of excessive calcium supplementation on cardiovascular health are recently suggested. Too high a level of vitamin D has been also reported to have severa...

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ba0005p327 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Gene expression profiling of osteoblastic cells cultured with lithocholic acid or bilirubin. Implications in the pathogenesis of osteoporosis in liver diseases

Ruiz-Gaspa Silvia , Pares Albert , Dubreuil Marta , Combalia Andres , Peris Pilar , Monegal Ana , Guanabens Nuria

Low bone formation is considered to be the main feature in osteoporosis associated with cholestatic and end-stage liver diseases. Previous studies have demonstrated the deleterious consequences of retained substances such as lithocholic acid (LCA) and bilirubin (Bil) on osteoblastic cells. These effects are neutralized by ursodeoxycholic acid (UDCA). To gain new insights into cholestatic-induced osteoporosis, we have assessed the differential gene expression of osteoblastic ce...

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ba0005p328 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Use of proton pump inhibitors and hip re-fractures among Austrian hip fracture patients

Brozek Wolfgang , Reichardt Berthold , Zwerina Jochen , Peter Dimai Hans , Klaushofer Klaus , Zwettler Elisabeth

We retrospectively analyzed the incidence of hip re-fractures in Austrian hip fracture patients devoid of anti-osteoporotic drug treatment, taking vs not taking proton pump inhibitors (PPIs).For 31,668 patients ≥50 years sustaining a hip fracture in Austria between July 2008 and December 2010, information on hip re-fractures with follow-up until June 2011 and on filed prescriptions of PPIs and anti-osteoporotic drugs between July 2007 and June 2011...

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ba0005p329 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

The role of melatonin in regulating autophagy in type 2 diabetic osteoporosis

Zhang Weilin , Meng Hongzheng , Yang Maowei , Sun Guanghong , Liu Junhua , Shi Pengxu , Liu Fei , Yang Bo

Objective: The study of melatonin on the levels of autophagy in bone will contribute to new type 2 diabetes osteoporosis-pathological processes by which a specific role and mechanism for the treatment of type 2 diabetes-induced osteoporosis could emerge.Method: This study consists of a two-part experiment. We assessed different body parameters in rats, a type 2 diabetes model application, utilizing different concentrations of melatonin interventions, the...

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ba0005p330 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Regression analysis between multiple osteoporotic spine fracture and osteoporotic fracture risk factors

Lee Jaewon , Park Ye-Soo

Objectives: There are some studies that evaluated changes of bone marrow density (BMD) and re-fracture after zoledronic acid injection. However, there is no study that showed about the fracture on all of the body, fracture healing, and improvement of clinical symptom after zoledronic acid injection. In this study, authors evaluated the 1-year BMD change, changes of lumbar pain in lumbar spine fractures, effects on fracture healing, re-fracture and additional fracture on other ...

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ba0005p331 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

The effects of vitamin D and sarcopenia on bone mineral density in Korean women

Ki Thein Myat , Won Yang Sung , Hoon Lee Sang , Nam Kim Kyu , Min Kim Kwang , Joo Lee Duck , Taeck Kim Bom

A osteoporotic fracture has become a global health issue that causes tremendous impact on mortality as well as heavy socioeconomic burden. Previous studies suggested that vitamin D may prevent fractures by improving muscle mass as well as via increasing bone density directly. The purpose of the study is to determine that the influence of vitamin D on bone mineral density depends on its effects on muscle mass.We analyzed the data from Korean National Heal...

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ba0005p332 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Elevated body iron stores and circulating osteoprotegerin as independent predictors of hip fracture in postmenopausal women admitted for fragility fracture: time for new screening strategies?

Shargorodsky Marina

Background: Identification of risk factors may help us to understand the pathogenesis of osteoporotic hip fracture as well as to formulate development of better diagnostic, prevention and treatment strategies. The present study was designed to determine the impact of multiple metabolic risk factors such as markers of systemic inflammation (C-reactive protein), body iron stores (ferritin), insulin resistance (HOMA-IR) and bone remodeling (osteoprotegerin), for the prediction of...

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ba0005p333 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Risk factor profile and bone mass findings

Praest Holm Jakob , Beck Jensen Jens-Erik , Hyldstrup Lars

Objective: To evaluate prevalent risk factors, medication use and comorbidities with bone mass findings at the total hip, femoral neck and lumbar spine.Design: Historical cross-sectional study.Methods: A total of 6285 women and 565 men consecutively referred to an osteoporosis specialist clinic from 2000 to 2012 were included. Information of potential risk factors was obtained from a clinical database. Additional information on med...

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ba0005p334 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Incidence of clinical vertebral fractures in north-eastern Germany

Schober Hans-Christof , Wilk Tim , Westphal Thomas , Mittlmeier Thomas

Background: Current studies concerning the incidence of vertebral fractures are rare. Knowledge about age and sex dependency of these fractures could help focussing therapeutic decisions. Therefore, we performed a prospective study in order to find a reliable incidence of clinical vertebral fractures in an adult population.Methods: Included were all patients with radiologic confirmed clinical vertebral fractures, which occurred in the adult population (a...

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ba0005p335 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Qulaity of life of patients with osteoporotic vertebral compression fractures

Young Park Si , Jin Jung Ho , Soo Park Ye , Yeon Seo Hyoung , Chul Lee Jae , Joon Shin Byung , Chan An Ki

Introduction: As Korean society have been entered to aging population, osteoporosis is considered one of the most important disease in the elderly. Osteoporotic vertebral compression fractures can affect to patients quality of life. But, in Korea, there is few studies about this, so we investigated.Aim: To evaluate the quality of life of patients with vertebral compression fracture.Methods: This study was performed in multice...

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ba0005p336 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Epidemiology of community-dwelling elderly vertebral fracture in China southern city: study of osteoporotic fractures (Part I)

Gao Chao , Zhang Zhenlin

Objective: Osteoporotic fracture is the most severe complication of osteoporosis and vertebral column suffer the highest risk. The aim of the part I study was to evaluate the prevalence of vertebral fracture, distribution of prevalent fractures as well the grade of the fractures in community-dwelling elderly in China southern city.Methods: A population of 6142 elderly over 50 years old from four communities in China southern city was gathered voluntarily...

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ba0005p337 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Longitudinal increase in vitamin D binding protein levels after initiation of tenofovir/lamivudine/efavirenz therapy among HIV-infected individuals

Hsieh Evelyn , Fraenkel Liana , Han Yang , Xia Weibo , Insogna Karl , Yin Michael , Zhu Ting , Cheng Xinqi , Li Taisheng

Tenofovir disoproxil fumarate (TDF) is a critical component of first-line antiretroviral regimens for HIV worldwide. However, TDF-containing regimens have been associated with decreased bone mineral density and increased fracture risk, which may in part be mediated through secondary elevations in parathyroid hormone (PTH). Prior cross-sectional data suggest vitamin D binding protein (DBP) levels may increase with TDF exposure leading to a functional vitamin D deficiency, which...

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ba0005p338 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Nonalcoholic fatty liver disease is associated with postmenopausal osteoporosis

Moon Seong-Su , Lee Young-Sil , Kim Taekyoon

Osteoporosis is known to be associated with metabolic diseases characterized by insulin resistance, such as central obesity, diabetes, and metabolic syndrome. Non-alcoholic fatty liver disease (NAFLD) is also increased in such insulin resistant conditions. However, little is known about whether osteoporosis and nonalcoholic fatty liver disease are etiologically related to each other or not. We investigated whether bone mineral density(BMD) is associated with NAFLD in pre- and ...

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ba0005p339 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

High prevalence of reduced bone mineral density and undertreatment of osteoporosis in patients with systemic sclerosis

Spanjer Moon J , Bultink Irene E M , Voskuyl Alexandre E , Lems Willem F

Purpose: Systemic sclerosis (SSc) is a rare inflammatory rheumatic disease that has been associated with an increased risk of low bone mineral density (BMD). However, data on risk factors associated with bone loss in SSc are scarce. The objective of this study was to investigate the prevalence of and the risk factors for low BMD in patients with SSc.Methods: Cross-sectional data of 61 patients with SSc were collected. BMD in the lumbar spine, total hip a...

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ba0005p340 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Current trends and future projection of hip fracture in South Korea using nationwide claims data

Ha Yong-Chan , Kim Deog-Yoon , Lee Young-Kyun , Kim Ha-Young , Cho Eun-Hee , Jang Sunmee

Introduction: The purposes of this study were to evaluate the trends in the incidence and mortality of hip fracture between 2008 and 2012, and predict the number of hip fractures in Korea up to 2025, using nationwide claims data.Methods: Nationwide claims data managed by the National Health Insurance Service (NHIS) was used to identify patients with hip fracture. All new visits or admissions to medical institutes for hip fracture aged 50 years or more be...

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ba0005p341 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Trend of incidence, mortality, and future projection of vertebral fracture in Korea using nationwide claims data

Lee Young-Kyun , Kim Tae-Young , Jang Sunmee , Kim Ha-Young , Kim Deog-Yoon , Cho Eun-Hee , Ha Yong-Chan

Introduction: Vertebral fracture has been recognized as a major health concern. Our purposes were to evaluate the trends in the incidence and mortality of vertebral fracture between 2008 and 2012 and predict the number of vertebral fracture that will occur in Korea up to 2025, using nationwide data from the National Health Insurance Service (NHIS).Method: A nationwide data set was evaluated to identify all new visits to medical institutes for vertebral f...

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ba0005p342 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Short-term smoking cessation improved bone formation in healthy male smokers

Watanabe Reiko , Tai Nobuyuki , Hirano Junko , Masaki Hiroaki , Okazaki Ryo , Inoue Daisuke

Background and Aim: Smoking increases fracture risk and contributes to COPD-associated osteoporosis. However, its impact on bone metabolism is largely unknown. We thus aimed to determine the effect of smoking cessation on bone metabolism.Subject and Method: In this prospective study, we recruited 29 healthy Japanese male subjects with smoking habit (37.7±8.2 years old, 16.9±11.3 pack years). Pulmonary function test was done before smoking cessa...

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ba0005p343 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Ultrastructure of biomineral of the ramus of mandible in rats after implantation of manganese enhanced hydroxyapatite implants into tibia

Astrakhantsev Dmitry , Luzin Vladyslav , Berezhnoy Evgeny , Stklyanina Lubov

Objectives: The study is aimed at analysis of ultrastructure of biomineral of the ramus of mandible after implantation of manganese enhanced hydroxylapatite into the tibia.Methods: The study involved 252 male rats. The 1st group comprised intact animals, the 2nd group animals with 2.2 mm defect in the tibia, and the groups 3 through 6 the animals with the defects filled with hydroxylapatite enhanced with 0.0, 0.1, 0.25, and 0.5% share of ma...

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ba0005p344 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Ultrastructure of the hipbone biomineral in white rats with defect of the tibia after 60-day administration of sodium benzoate

Lukyantseva Galyna , Luzin Vladyslav , Bybyk Valery , Morozov Vitaly

Objectives: This study thus was aimed at investigating of ultrastructure of the hipbone biomineral in rats with defect in tibia after 60-day per os administration of sodium benzoate (SB) in various concentrations and mexidol (M).Methods: The experiment involved 280 male thoroughbred rats with initial body weight of 200210 g. The 1st group (K) comprised animals that received daily per os 1 ml of 0.9% solution of NaCl, the 2nd and t...

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ba0005p345 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

The effects of 60-day sodium glutamate intake and exposure to ionizing radiation on ultrastructure of biomineral of the ramus of mandible in rats

Simrok Ksenia , Luzin Vladyslav , Miakotkyna Galyna , Skryabina Elena

Objectives: The study is aimed at investigation of ultrastructure of biomineral of the ramius of mandible (BRM) in rats after application of sodium glutamate (SG) and exposure to ionizing radiation (IR), and finding possibility of medication with Spirulina (SP).Methods: The experiment involved 240 rats with body weight of 180200 g. The animals were distributed into eight groups as follows: intact animals for the controls, animals that received ...

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ba0005p346 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Macroelemental contents of skeletal bones after 60-day exposure to toluene vapors in rats of different ages

Skorobogatov Andrey , Luzin Vladyslav , Hryshchuk Maxim , Shutov Evgeny

Objectives: This experimental study is aimed at investigating of macroelemental contents of skeletal bones in rats after 2-month inhalation of toluene vapors (Tol) and administration of thiotriazoline (Th) and Echinaceae tinctura (ET) as medication.Methods: The experiment involved 420 male rats (young, mature and old) each separated into: intact animals, animals that received daily Tol inhalations as a single 5-h exposure to 10 MPC for ...

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ba0005p347 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Development of Korean Fracture Risk Score predicting osteoporotic fracture risk: analysis of data from the Korean National Health Insurance Service

Kim Ha-Young , Jang Eun-Jin , Park Byeong Ju , Ha Y-C , Jang Sunmee

Background: Asian-specific prediction model for estimating the individual risk of osteoporotic fracture was rare. We aimed to develop a Korean fracture risk prediction model using clinical risk factors and assess external validity of the final model.Methods: A total of 718,306 Korean men and women aged 5090 were followed for 7 years in national system based cohort study. Fifty percent were randomly assigned to the development dataset and 50% to the...

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ba0005p348 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

The relationship between osteoporosis and urine ACR in postmenopausal women with type 2 diabetes

Cho Nanhee , Kim Hanbyul , Lee Yeyeon , Cho Hochan

Purpose: Osteoporosis is a progressive bone disease that is characterized by a decrease in bone mass, density and destruction of microstructure, which can lead to an increased risk of fracture. Although many studies have been published about relationship between end-stage renal disease and osteoporosis, but research on the relationship between proteinuria and the prevalence of osteoporosis is still lacking.Methods: We assessed 91 postmenopausal women wit...

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ba0005p349 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Relationships between the trabecular bone score (TBS) and glucose metabolism indices in healthy postmenopausal women

Nawata Kiyoko , Yamauchi Mika , Yamamoto Masahiro , Sugimoto Toshitsugu

Purposes: The trabecular bone score (TBS) is an indicator of cancellous bone microstructure obtained from image analysis with lumbar spine dual-energy X-ray absorptiometry (DXA) scans. A decrease in TBS is considered to be a risk factor for vertebral fracture that is independent of BMD. At the same time, it has been reported that, BMD was higher and TBS was lower in women with type 2 diabetes mellitus (DM), and a decreasing TBS is risk factor for fracture. However, the relatio...

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ba0005p350 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Bone mineral density in women with Parkinson’s disease

Povoroznyuk Vladyslav , Bystrytska Maryna , Karaban' Irina , Karasevych Nina

Aim: The aim of the research is to define the bone mineral density in patients, with Parkinsons disease.Methods: We examined 12 women with Parkinsons disease and 12 healthy women of appropriate age (average age: −63.6±6.25 vs 62.2±6.83 years, P=0.5). The duration of Parkinsons disease was at list 5 years. All patients reseived levodopa.Results: BMD of women with Parkinsons disease wa...

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ba0005p351 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Gender differences in presentation and outcomes in older hip fracture patients

Maher Niamh , Steen Georgina , Fallon Nessa , Browne Joseph , Walsh James Bernard , Casey Miriam

Introduction: Hip fracture is a significant health problem with 2530% occurring in men. Outcome differences between the genders have been documented, particularly mortality rates.Aim: To prospectively investigate outcomes of elderly hip fracture patients regarding mortality, recovery of function, quality of life, incidence of osteoporosis, osteoporosis knowledge, medication adherence, nutritional status and fear of falling.Me...

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ba0005p352 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Atypical femur fractures (AFF): a case-control study

Imel Erik , Eckert George , Allen Katie , Chandler Julie , Martin Joel , Hui Siu , Johnston C Conrad , DePapp Anne , Santora Art , Choplin Robert , Roth Trenton , Liu Ziyue

Atypical femur fractures (AFF) have been associated with antiresorptive therapy. In a retrospective case-control study, we identified AFF using ASBMR 2013 criteria. Femoral shaft fractures were identified using ICD9 codes. We screened 1479 radiographs. Radiographs were excluded for high-energy trauma, tumor, or periprosthetic fracture. Two radiologists blinded to treatment scored 482 radiographs for AFF features, and jointly adjudicated discrepancies. The required AFF feature,...

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ba0005p353 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Dietary potassium intake is beneficial to bone health in Korean adults with low dietary calcium intake: the Korean National Health and Nutrition Examination Survey (KNHANES) (2008–2011)

Kim Jung Hee , Kong Sung Hye , Hong A Ram , Lee Ji Hyun , Kim Sang Wan , Shin Chan Soo

Nutrition is a major modifiable factor that affects bone health. Dietary potassium may act as an alkaline source by neutralizing the acid load and reducing calcium loss from bone.We aimed to evaluate the association between dietary potassium intake and bone mineral density (BMD) in the Korean population. We analyzed data from the Korean National Health and Nutrition Examination Survey (KNHANES) A total of 3135 men aged >50 years and 4052 postmenopaus...

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ba0005p354 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Bone metabolism in patients with anorexia nervosa and amenorrhea

Gatti Davide , Idolazzi Luca , el Ghoch Marwan , Viapiana Ombretta , Calugi Simona , Rossini Maurizio , Caimmi Cristian , Braga Vania , Radetti Giorgio , Adami Silvano , Grave Riccardo Dalle

Context: Anorexia nervosa (AN) occurs predominantly in females, most frequently during adolescence and it is generally associated with amenorrhoea. AN increases the risk for impaired bone health and for low bone mineral density (BMD) by a mechanism which has not been yet well defined.Objective: The study purpose was to further characterize bone metabolism in AN with amenorrhoea, and so with oestrogen deficiencyDesign: AN patients w...

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ba0005p355 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

The correlation between number and population of bone marrow endothelial progenitor cells with bone mass and bone metabolism in the elderly

Cheng Qun , Lin Shangjin , Bi Bo , Fan Yongqian , Lin Weilong

Objective: Endothelial progenitor cells (EPCs) have the potential ability to differentiate into vascular endothelial cells and osteoblasts for angiogenesis and osteogenesis, however, the correlation between number and population of bone marrow EPCs with bone mass and bone metabolism in elderly is unknown.Methods: Trabecular bone were extracted from 11 patients with fragility fracture and eight patients with osteoarthritis during artificial hip replacemen...

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ba0005p356 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

The added value to FRAX of gait speed and tests of postural balance

Lundin Hans , Saaf Maria , Strender Lars-Erik , Salminen Helena

Objectives: Postural balance and gait speed are risk factors for falls and hip fractures independent of bone mineral density (BMD). The standard risk assessment tool, FRAX, does however not include any estimate of fall risk. Identifying high-risk individuals correctly is be of great clinical importance why further improvement of FRAX would be clinically valuable. The primary aim of this study was to see if one-leg standing time, the maximum number of steps on a line or gait sp...

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ba0005p357 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Older urban Black South African women are increasingly at risk of low bone mass and high bone turnover

Kruger Marlena , Kruger Salome , Wright Hattie , Schutte Willem , Kruger Iolanthe

South African studies indicated that urban Black and White women have similar bone turnover. However, urban Black women had low bone mass and greater exposure to lifestyle risk factors for bone disease. The purpose of this prospective study was to assess changes in bone turnover, parathyroid hormone (PTH) levels, bone health (forearm, hip and lumbar spine bone mineral density) in urban black South African women over 3 years. Black, urban postmenopausal women (n=144, &...

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ba0005p358 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Treatment pattern and its cost of vertebral fracture among elderly patients in Korea

Kim Dam , Ahn Jeonghoon , Sung Yoon-Kyoung

Objectives: Vertebral fracture (VF) is a hallmark of osteoporosis, and it increases morbidity, mortality and large amount of medical cost. In this study, we aimed to describe the treatment pattern and estimate the cost of VF among elderly patients in Korea.Methods: Using Korean national healthcare claims database, we analyzed a 2% sample of patients aged &gE; 50 years between years of 2008 and 2012. New VF was identified on the basis of selected ICD-10 c...

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ba0005p359 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Glucocorticoid acts differently on vertebral and hip fractures in Korean RA patients using National healthcare claims database

Kim Dam , Cho Soo-Kyung , Park Byeongju , Jang Eun Jin , Bae Sang-Cheol , Sung Yoon-Kyoung

Background and objectives: Fracture in rheumatoid arthritis (RA) patient is more frequent than general population. One of the important reasons is use of glucocorticoid (GC) for treatment of RA. In this study, we aimed to identify the effect of GC on fracture of different site.Methods: Among RA patients &gE;19 years, we established a retrospective cohort using Korean national healthcare claims database from Jan 2010 to Dec 2010, and then followed up unti...

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ba0005p360 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Warfarin use and changes in bone mineral density in the population-based canadian multicentre osteoporosis study (CaMos)

Vaninetti Nadine , Kirkland Susan , Thompson Kara , Theriault Chris , Prior Jerilynn , Kovacs Christopher , Adachi Rick , Towheed Tanveer , Leslie William , Davison K Shawn , Morin Suzanne , Goltzman David , Kaiser Stephanie

Background: Osteocalcin has an important role in bone metabolism. Uncarboxylated osteocalcin predicts risk for hip fracture and lower bone mineral density (BMD). Warfarin inhibits carboxylation of osteocalcin, providing a mechanistic link between warfarin and impaired bone metabolism. Studies examining the relationship between warfarin use and BMD have been inconsistent. The goal of this study was to further characterize this relationship.Population: CaM...

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ba0005p361 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

The relationship of serum serotonin levels to the rate of bone loss and fractures in men

Baek Kihyun , Kang Mooil , Kim Meekyoung

Recent genetic studies in rodents have revealed that circulating serotonin plays a key role in regulating bone formation and skeletal mass. However, the reported effects of circulating serotonin on bone mass in humans have been conflicting. We determined whether circulating serotonin levels influenced the rate of bone loss and fractures in males.We assessed the effect of serum serotonin on bone loss rate in a population-based cohort of 202 ambulatory mal...

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ba0005p362 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Differential influence of social network upon osteoporosis affected by intimacy in Korean elderly women

Lee Seungwon , Hea Seo Da , Min Kim Kyoung , Chang Kim Hyeon , Oh Kim Chang , Youm Yoosik , Rhee Yumie

The present study figured out the relationship between social network and osteoporosis among elderly women. Social network could be beneficial to ones health since it works as social capital providing several supports. On the other hand, social network can also be a source of social burden aggravating ones health. To examine the seemingly contradicting associations, Korean Urban Rural Elderly Study (KURE) data was analyzed. There were 1938 older women aged over 65,...

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ba0005p363 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Lower FRAX scores but similar femoral neck aBMD in UK dwelling postmenopausal South Asian women as compared with same age Caucasian women

Darling Andrea L , Hart Kathryn H , Lanham-New Susan A

It is unclear as to whether western dwelling South Asian (SA) postmenopausal women have a different fracture risk to that of the native Caucasian (C) population. Moreover, the WHO Fracture Risk Assessment Tool (FRAX) has not been used previously to compare predicted risk of fractures in western dwelling South Asian women with same-age Caucasian women. This analysis used data from n=35 SA [mean (S.D.) age=59 (6) years] and n=136 C [mean (...

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ba0005p364 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Peak bone mass and quantitative ultrasound bone properties in young adulthood: a study in the PEAK-25 cohort

Sandstrom Linnea , McGuigan Fiona , Callreus Mattias , Akesson Kristina

Peak bone mass, typically reached in the third decade, is the highest bone mass acquired after completion of normal growth. Attaining a higher young adult bone mass may contribute to a lower risk of fragility fractures later in life. Few studies have specifically investigated quantitative ultrasound (QUS) in relation to peak bone mass in young adult women. The study objectives were to describe normative QUS values for 25 year old women and how extremes of body weight relate to...

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ba0005p365 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Prevalence and related factors assessment of osteoporotic fracture in rural population: the Korean Genomic Rural Cohort study

Won Young Jun , Lim Jung Soo , Choi Soo In , Shin Young Goo , Chung Choon Hee , Jang Sae Jin , Koh Sang Beak , Ryu So Yeon , Lee Tea Yung , Song Jea Suk

Objective: Due to the increase in the elderly population, osteoporosis and related fractures are increasing and causes serious social problems such as lower quality of life of seniors and economic loss. This study is aimed towards the general population in rural areas for prevalence and related risk factors of osteoporotic fracture.Materials and methods: The research comes from the Korean Rural Genomic Cohort study consisting of 10 111 people, 4090 men a...

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ba0005p366 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Effect of recent spinal cord injury on the OPG/RANKL system and its relationship with bone loss and antiosteoporotic response to denosumab therapy: preliminary results

Gifre Laia , Vidal Joan , Ruiz-Gaspa Silvia , Portell Enric , Monegal Ana , Muxi Africa , Guanabens Nuria , Peris Pilar

The aims of this study were to analyze the role of the regulators of bone remodeling, OPG and RANKL, in the bone loss associated with recent spinal cord injury (SCI) as well as the effect of antiosteoporotic therapy with denosumab in these bone regulators in a prospective study.Patients and methods: Twenty-three male patients (aged 1867 years (mean 36±16 years)) with recent (<6 months) complete SCI were prospectively included (43.5% parapl...

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ba0005p367 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

FGF23 and SCL are expressed in carotid plaques and the association between their circulating fractions and fractures differs in relation to comorbidity in elderly individuals

Rotatori Stefano , Corallo Claudio , Merlotti Daniela , Rendina Domenico , Bianciardi Simone , Patti Aurora , Gonnelli Stefano , Evangelista Isabella Anna , Lucani Barbara , Franci Maria Beatrice , Setacci Carlo , Strazzullo Pasquale , Nuti Ranuccio , Dotta Francesco , Gennari Luigi

Sclerostin (SCL) and FGF23 are osteocyte-secreted factors with a major role in bone homeostasis. Despite their skeletal effects and their association with fracture risk in some studies, variations in circulating levels were also described in patients with diabetes (DM), chronic renal failure (CRF) and/or cardiovascular disease (CVD). In order to provide further insight on the relationship between these osteocyte-derived factors, osteoporosis and cardio-metabolic disorders we a...

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ba0005p368 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Gender-different relationship between body composition and incident fracture risk in Koreans: a community-dwelling prospective cohort study

Kim Jung Hee , Hong A Ram , Choi Hyung Jin , Ku Eu Jeong , Cho Nam H , Shin Chan Soo

Low body mass index (BMI) or body weight is a well-known risk factor for osteoporosis and fragility fractures. However, the relative contribution of lean mass and fat mass on bone health, i.e. fragility fractures is inconclusive.We elucidated the relative contribution of lean and fat mass on fracture risk by group analysis in Korean men and women. This was an ongoing prospective community-dwelling cohort study at Ansung in Korea, begun in 2001. We includ...

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ba0005p369 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Osteoporosis-related knowledge and health beliefs among female community leaders in Peru

Sava Mihaela , Hsieh Evelyn , Garcia Patricia , Mabey David

Background: Postmenopausal women are at high risk for osteoporosis, and early adoption of osteoporosis-preventative behaviours, such as physical activity and dietary calcium intake, can help mitigate this risk. Behavioural studies have shown that knowledge and health beliefs are key factors associated with adoption of healthy behaviours. There are few such studies regarding osteoporosis in South America. Our aim was to conduct an exploratory study evaluating osteoporosis-relat...

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ba0005p370 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Incidence of hip fracture in 2010 in Lithuanian residents over 40 years of age

Tamulaitiene Marija , Mastaviciute Asta , Urmanavicius Matas , Martinaityte Raminta , Alekna Vidmantas

Objective: To assess the incidence and distribution of hip fractures by sex and age among individuals over 40 years in Lithuania in 2010.Materials and methods: This population-based study was performed collecting the data from all orthopaedic-traumatology inpatient departments in Lithuania. The case histories of Lithuanian residents over 40 years, who had suffered a hip fracture in 2010, were examined. Subjects with primary hip fracture (ICD-10 codes S72...

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ba0005p371 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Seasonal and environmental effect on the incidence of hip fractures and non hip fractures in Italy

Tarantino Umberto , Feola Maurizio , Rao Cecilia , Guazzini Andrea , Piscitelli Prisco

Background and objective: Data concerning the incidence of fractures in Italy have been displayed since year 2000 by analysing hospital discharge records (HDRs). However, the influence of seasonal and environmental factors on fracture events in the Italian population has not yet been assessed.Methods: We have analyzed HDRs for primary diagnosis of hip, vertebral, forearm, humeral and knee fractures in Italy from year 2007 to 2009. Inferential statistics ...

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ba0005p372 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Sex hormone-binding globulin is associated with markers of vertebral fracture and vertebral fracture risk

Koromani Fjorda , Muka Taulant , Oei Ling , Zillikens Carola , Hofman Albert , Uitterlinden Andre G , Oei Edwin , Hans Didier , Franco Oscar H , Rivadeneira Fernando

Background: The relation between sex hormone-binding globulin (SHBG) and vertebral fracture (VFx) is unclear.Aim: To examine whether SHBG is associated with bone mineral density at lumbar spine (LS-BMD), trabecular bone score (TBS) and prevalent VFx.Methods: Data of 6224 men and women participants in the third visit of the first cohort (I-3) and the first visit of the second cohort (II-1) of a prospective population based cohort, w...

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ePoster

ba0005p373 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

The association between diabetes, trabecular bone score, bone mineral density and vertebral fractures

Koromani Fjorda , Muka Taulant , Oei Ling , Zillikens Carola , Hofman Albert , Franco Oscar H , Uitterlinden Andre G , Oei Edwin , Hans Didier , Rivadeneira Fernando

Background: Fracture risk is increased in Type 2 diabetes (T2D) individuals. Bone mineral density (BMD) is inversely associated with fracture risk but paradoxically high in T2D individuals. Trabecular bone score (TBS) reflects bone microarchitecture and predicts fracture risk.Objective: We aimed to compare mean lumbar spine TBS (LS-TBS) and lumbar spine BMD (LS-BMD) values, across individuals with and without i) vertebral fracture (VFx), ii) T2D; and iii...

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ePoster

ba0005p374 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Long term follow-up of fracture incidence and fracture prediction from bone mineral density

Trajanoska Katerina , de Jonge Ester A L , Kieboom Brenda C T , Mulder Marlies , Stricker Bruno H C , Franco Oscar H , Uitterlinden Andre G , Rivadeneira Fernando

Introduction: Due to the greying of (industrialized) societies the incidence of osteoporosis and fragility fractures is expected to be increasing. Our aim was to investigate in an elderly population if the incidence of non-vertebral fractures (overall and site specific) has changed after a longer follow-up, and its relation with osteoporosis or osteopenia assessed by bone mineral density (BMD) at baseline.Methods: Incident non-vertebral fract...

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ba0005p375 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Neuropathic pain component in patients with osteoporosis and low back pain

Povoroznyuk Vladyslav , Shinkarenko Tetiana , Pryimych Uliana

The aim of this study was to estimate the structure of pain syndrome and reveal the presence of neuropathic pain component in patients suffering from the osteoporosis and low back pain.Material and methods: We have examined 107 patients aged 4589 years (average age 68.1±1.2 years). Patients were divided into 2 groups: A patients with osteoporosis (n=49), B patients with low back pain (n=58). And according to age...

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ba0005p376 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Tumor necrosis factor superfamily members in bone loss in men with end-stage chronic obstructive lung disease

Kochetkova Evgenia , Ugay Ludmila , Maistrovskaia Yuliya

Aim: To assess the relationships of serum osteoprotegerin (OPG), receptor-activator of nuclear factor-κB ligand (RANKL) and tumor necrosis factor-alpha (TNF-α) superfamily with bone composition in end-stage COPD.Methods: Body and bone composition, serum OPG, RANKL, TNF-α and its receptors (sTNFR I, sTNFR II), TNF-related apoptosis-inducing ligand (sTRAIL) levels were measured in 48 men end-stage COPD accepted for lung transplantation, and ...

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ba0005p377 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

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ba0005p378 | Osteoporosis: pathophysiology and epidemiology | ECTS2016

Bone mineral density and associated risk factors: in healthy Indian population

Waghdhare Swati , Kaushal Neelam , Jalali Rajinder K , Vohora Divya , Jha Sujeet

Introduction: Osteoporosis is a global public health problem affecting more than 200 million people worldwide. Osteoporosis has clinical and public health implications because of the mortality, morbidity, and cost of medical care associated with osteoporotic fractures. The World Health Organization (WHO) has defined criteria for assessing bone status by DEXA, which are defined by the T-score, which is the number of standard deviations (SDs) by which a patients t...

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43rd Annual European Calcified Tissue Society Congress

BiosciAbstracts