Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp317 | Osteoporosis: evaluation and imaging | ECTS2013

A 3D QCT technique of the thoracic and lumbar spine: integral volume and intervertebral disc space increase and bmd decreases from T6 to L4

Museyko Oleg , Heinemann Axel , Krause Mattias , Barkmann Reinhard , Amling Michael , Gluer Claus , Puschel Klaus , Engelke Klaus

Introduction: QCT of the spine is typically restricted to the BMD analysis of the lumbar vertebrae. However, fractures frequently occur in the thoracolumbar region. Also the load distribution in the spine may depend on the intervertebral disc space (IDS), a good approximation of the intervertebral disc, which itself cannot be reliably assessed by X-ray based methods.Materials and methods: A QCT 3D acquisition and automated analysis technique (with option...

ba0001pp71 | Bone development/growth and fracture repair | ECTS2013

Accuracy errors in longitudinal QCT measurements of cortical thickness bone mineral density and bone mineral content using different segmentation techniques: a simulation study

Gerner Bastian , Museyko Oleg , Topfer Dominique , Engelke Klaus

Introduction: The quantification of cortical BMD and thickness in QCT images remains challenging due to the limited spatial resolution of CT scanners. We simulated the impact of longitudinal cortical BMD and thickness changes on accuracy of cortical measurements using three different segmentation algorithms.Methods: A step function of varying width d (cortical thickness) and height (cortical BMD) and an additional step representing trabecular BMD was con...

ba0005p39 | Bone biomechanics and quality | ECTS2016

Depth and location dependence of subchondral trabecular structure across the tibia in human osteoarthritic knee versus normal knee: a micro-CT study

Bouhadoun Hamid , Engelke Klaus , Laredo Jean Denis , Chappard Christine

Objective: To determine differences between osteoarthritic (OA) knees with normal knees for subchondral trabecular bone structure according to depth and location in the tibial plateau.Methods: In a population of 30 cadaveric left knees (18 women and 12 men, mean age: 79.1 years±8.2, range: 63–90) the Kellgren-Lawrence (KL) score was determined from post mortem radiographs: OA=KL≧2 (n=6 women, n=5 men) and controls=KL &#8804...

ba0001pp451 | Osteoporosis: treatment | ECTS2013

Estimation of vertebral and femoral strength during the first three years of denosumab therapy using an alternative smooth non-linear finite element methodology

Zysset Philippe , Pahr Dieter , Engelke Klaus , Genant Harry , McClung Michael , Kendler David , Recknor Christopher , Kinzl Michael , Schwiedrzik Jakob , Museyko Oleg , Wang Andrea , Libanati Cesar

Denosumab subcutaneous administration every 6 months reduced the incidence of new fractures in postmenopausal women with osteoporosis by 68% at the spine and 40% at the hip over 36 months compared with placebo in the FREEDOM study (Cummings et al., NEJM, 2009:361:756). This efficacy was supported by differential improvements from baseline in vertebral and femoral strength at 36 months (18.2 and 8.6%, respectively) estimated by an established voxel-based finit...

ba0003pp239 | Osteoporosis: evaluation and imaging | ECTS2014

Impact of metal artefacts in QCT of the hip caused by a contralateral Gamma type nail: an ex vivo study

Engelke Klaus , Bouler Nicolas , Fuerst Oleg Museyko , Parratte Sebastien , Fuerst Thomas , Pion Francois-Xavier , Champsaur Pierre , Genant Harry , Corroller Thomas Le

Introduction: Gamma type nails are routinely used for the fixation of intertrochanteric fractures of the proximal femur. QCT at the hip is an advanced method that is increasingly being used to estimate BMD and determine the future fracture risk. Yet, implants cause metal artefacts (MA) in CT images, even at the contralateral side due to the high absorption of metal, which may impair BMD accuracy.Methods: Three human cadavers were scanned first without an...

ba0005oc3.1 | Clinical trials, FGF-23 and focal osteoporosis | ECTS2016

Effect of odanacatib on bone density and estimated bone strength in postmenopausal women: a CT-based sub-study of the phase 3 long-term odanacatib fracture trial (LOFT)

Langdahl Bente , De Villiers Tobias , Keaveny Tony M , Engelke Klaus , Genant Harry , Ather Shabana , Giezek Hilde , Lombardi Antonio , Leung Albert , de Papp Anne

Odanacatib (ODN), a selective oral inhibitor of cathepsin K, is in development for the treatment of osteoporosis. In the Phase 3, Long-Term ODN Fracture Trial (LOFT; NCT00529373), ODN significantly reduced fracture risk. This imaging sub-study primarily investigated the effect of ODN on volumetric BMD (vBMD) of the lumbar spine (LS) and total hip (TH) using quantitative computed tomography (QCT).Women aged ≥65 without baseline radiographic vertebra...