Searchable abstracts of presentations at key conferences on calcified tissues

ba0003pp332 | Osteoporosis: treatment | ECTS2014

Denosumab therapy of osteoporosis in patients after solid organ transplantation and impaired renal function

Brunova Jana , Kratochvilova Simona

The therapy of osteoporosis in patients with end organ failure and after the transplantation (Tx) becomes more frequent problem with the better patients and graft survival rates. Moreover some of these patients have impaired renal function and therefore cannot use bisphosphonates. The supplementation therapy with calcium and/or vitamin D is frequently not sufficient to improve bone mass. The possible innovative therapy is Denosumab (Prolia inj.) - MAB to RANK, which is not con...

ba0006p122 | (1) | ICCBH2017

Bisphosphonate treatment initiated in the newborn period – our experience

Bayer Milan , Jirotkova Jana

Background: Osteogenesis imperfecta (OI) is a clinically heterogenous heritable connective tissue disorder with increased bone fragility. Intravenous bisphosphonate therapy is the most widely used medical approach. This treatment leads to an increase of the bone mineral density and reduces the fracture rate.Presenting problem: We present our experience with five OI patients (one female, four males) between 2005 and 2016 who had bone fractures either in u...

ba0007p161 | (1) | ICCBH2019

Endocrinological complications in Czech paediatric patients with Duchenne muscular dystrophy

Sediva Marie , Soucek Ondrej , Haberlova Jana

Objectives: Duchenne muscular dystrophy (DMD) is a rare hereditary X-linked muscular dystrophy affecting approximately 1:5.000 live borne males. The mobility and respiratory complications have been improved by implementing the glucocorticoid treatment in DMD, however, secondary osteoporosis, short stature and delayed puberty emerged as unwanted side-effects of the treatment. We aimed to evaluate the endocrinological complications in boys with DMD followed at our neuromuscular ...

ba0001pp276 | Genetics | ECTS2013

No association between the CYP1B1/Leu432Val polymorphism and osteoporosis-related traits in Slovak postmenopausal women

Omelka Radoslav , Krajcovicova Vladimira , Spankova Jana , Durisova Jana , Martiniakova Monika , Galbavy Drahomir , Bauerova Maria

It is well known that sex hormone deficiency leads to increased bone turnover and subsequent bone loss. The metabolism of estrogens involves, among others, oxidation (mainly hydroxylation) by CYPs. The aim of this study was to determine whether Leu432Val polymorphism in the CYP1B1 gene is present also in Slovak population and subsequently, if it is associated with femoral and spinal bone mineral density (FBMD and SBMD), bone remodeling markers and fracture incidence in this po...

ba0003pp196 | Genetics | ECTS2014

Association of methylenetetrahydrofolate reductase (MTHFR) polymorphism (C677T) with clinical indicators of osteoporosis in postmenopausal Slovak women

Krajcovicova Vladimira , Durisova Jana , Galbavy Drahomir , Martiniakova Monika , Omelka Radoslav

Objective: The enzyme methylenetetrahydrofolate reductase (MTHFR) is known to play an important role in the removal of circulating homocysteine via the methionine cycle. C677T polymorphism is associated with higher plasma homocysteine levels, which could affect collagen maturation. The aim of the present study was to examine possible associations of C677T polymorphism in the MTHFR gene with a variability of femoral (F-BMD), spinal BMD (S-BMD) together with circulating...

ba0007p209 | (1) | ICCBH2019

Persistently low trabecular bone mineral density and normal bone strength at the radius over 3 years after simultaneous pancreas kidney transplantation

Soucek Ondrej , Sumnik Zdenek , Kratochvilova Simona , Brunova Jana

Objectives: Simultaneous pancreas kidney transplantation (SPKT) is a standard treatment option for adults with long-lasting (usually adolescence onset) type 1 diabetes (T1D) and concurrent renal failure. Despite the need for life-long immunosuppressive therapy the patients achieve better glycemic control, normalized renal function and an improved quality of life. Whether metabolic improvement is also reflected in the skeleton is not yet clear.Methods: Pa...

ba0003pp99 | Cancer and bone: basic, translational and clinical | ECTS2014

Changes in bone mineral density and biochemical markers of bone turnover in postmenopausal women with breast cancer initiating aromatase inhibitors therapy

Luchavova Maria , Zimovjanova Martina , Zikan Vit , Pribylova Jana , Cabinakova Michaela , Petruzelka Lubos

Postmenopausal women with early stage hormone-receptor-positive breast cancer (EBC) are standardly treated with aromatase inhibitors (AIs). However, one side-effect of AIs treatment is a decrease in bone mineral density (BMD) and an increased risk of fracture. The objectives of this study were to examine: i) changes in bone formation (N-terminal propeptide of type I procollagen; PINP) and bone resorption (cross-linked C-telopeptides of bone type I collagen; CTX) markers, as we...

ba0003pp197 | Muscle, physical activity and bone | ECTS2014

Girls with Turner syndrome have normal muscle force but decreased muscle power

Soucek Ondrej , Lebl Jan , Matyskova Jana , Snajderova Marta , Kolouskova Stanislava , Pruhova Stepanka , Sumnik Zdenek

Background: Turner syndrome (TS) is associated with decreased bone mineral density and altered bone geometry, which is assumed a risk factor leading to increased fracture rate. Although hypogonadism or SHOX gene haploinsufficiency are the probable causes, the exact mechanism remains unclarified. Particularly, the muscle function as an important determinant of bone strength has yet not been focused on in TS.Objective: We tested the hypothesis that there i...

ba0006lb7 | (1) | ICCBH2017

Musculoskeletal system in adolescents with type 1 diabetes

Maratova Klara , Soucek Ondrej , Matyskova Jana , Hlavka Zdenek , Petruzelkova Lenka , Obermannova Barbora , Pruhova Stepanka , Kolouskova Stanislava , Sumnik Zdenek

Background: Sarcopenia and osteoporosis are among the late complications of type 1 diabetes (T1D) in adults. Whether and to what extent musculoskeletal impairment is present in childhood and adolescence has yet to be determined. The aim of this study was to assess volumetric bone mineral density (BMD) and dynamic muscle function in adolescents with T1D and to assess the clinical and biochemical predictors of their musculoskeletal system.Methods: Ninety-f...