Searchable abstracts of presentations at key conferences on calcified tissues

ba0002is8 | The fracturing child: diagnostics | ICCBH2013

Non-invasive assessment of bone structure and strength using QCT and MRI

Leonard Mary

Skeletal development is characterized by sex-, race- and maturation-specific increases in bone strength. Studies using conventional QCT in the spine and femur, and peripheral QCT (pQCT) in the extremities provided insight into differences in compartment volumetric BMD (vBMD) and cortical dimensions but were limited by inadequate resolution to assess microarchitecture. For example, pQCT studies demonstrated that cortical vBMD was greater in females, while cortical section modul...

ba0002is8biog | The fracturing child: diagnostics | ICCBH2013

Non-invasive assessment of bone structure and strength using QCT and MRI

Leonard Mary

Biographical DetailsDr Mary Leonard, MD, MSCE is a Professor of Paediatrics and Epidemiology at the Perlman School of Medicine at the University of Pennsylvania, and the Director of the Office of Clinical and Translational Research at the Children’s Hospital of Philadelphia. Her multidisciplinary research program is focused on the assessment of bone health in children, and the detrim...

ba0002op14 | (1) | ICCBH2013

Inflammation and glucocorticoid therapy impair skeletal modeling during growth following crohn disease diagnosis

Tsampalieros Anne , Shults Justine , Zemel Babette , Baldassano Robert , Leonard Mary

Objectives: Examine changes in volumetric BMD and cortical structure following Crohn Disease (CD) diagnosis, and identify associations with growth, glucocorticoid exposure and disease activity.Methods: Prospective cohort study in 76 CD participants, ages 5–21 years. Tibia pQCT scans were obtained at diagnosis, 6, 12 and a median of 42 months later. Sex, race and age-specific Z-scores were generated based on >650 controls. Cortical dimen...

ba0006p086 | (1) | ICCBH2017

Feasibility and reproducibility using HRpQCTII in children and adolescents

Kent Kyla , Whalen Jessica , Strickland Ariana , Leonard Mary , Burghardt Andrew J.

We recruited 60 healthy volunteers ages 5 to 21 to perform scan-rescan precision tests on the XtremeCT II. Participants were positioned in a carbon fiber immobilization cast. iPad-based video content was used to facilitate motion-free compliance. Distal radius and tibia scans were acquired starting 2 mm proximal to the proximal margin of the growth plate or growth plate remnant. Diaphyseal radius and tibia scans were centered at an offset from the same landmark, corresponding ...

ba0006p099 | (1) | ICCBH2017

Bone strength and microarchitectural deficits in children with cystinosis

Burghardt Andrew , Kent Kyla , Long Jin , Whalen Jessica , Phelps Maira , Leonard Mary

Children with cystinosis have numerous risk factors for impaired bone accrual. We used state-of-the-art quantitative imaging of bone microarchitecture (HR-pQCT) to measure trabecular and cortical microstructure and bone strength in children and adolescents (5-20yrs) with cystinosis. We enrolled 20 cystinosis patients and recruited 34 healthy age- and gender- matched controls. Distal radius and tibia HR-pQCT scans (XtremeCT II, Scanco Medical) were acquired 2...

ba0007p17 | (1) | ICCBH2019

Sex and maturation effects on trabecular and cortical microarchitecture in children and young adults

Aye Tandy , Long Jin , Kent Kyla , Whalen Jessica , Strickland Ariana , Burghardt Andrew , Leonard Mary B

The impact of sex and maturation on trabecular (Tb) and cortical (Ct) microarchitecture in children and young adults has not been well established. The new second-generation high-resolution peripheral quantitative CT (HR-pQCT) scanner (XCT II, Scanco Medical) incorporates three important advances to provide greater spatial resolution, direct measures of Tb thickness and spacing and measures in the Ct midshaft. The aim of this study was to identify sex and maturation effects on...

ba0007p63 | (1) | ICCBH2019

Bone geometry and microarchitecture deficits in children with Alagille syndrome

Kindler Joseph , Mitchell Ellen , Piccoli David , Grimberg Adda , Leonard Mary , Loomes Kathleen , Zemel Babette

Objectives: Alagille syndrome (ALGS) is an autosomal dominant disorder attributed to mutations in the Notch signaling pathway. Children with ALGS are at increased risk for fragility fracture, but the etiology of this disposition is unknown. Our objective was to characterize bone mass, geometry, and microarchitecture in children with ALGS.Methods: This was a cross-sectional study of 10 children (9 females) ages 8-18 years, with a clinical diagnosis of ALG...

ba0002oc14 | Diagnostics | ICCBH2013

What DXA measurement sites are best for bone health assessment in children? Effect of inter-machine differences on bone outcomes from the Bone Mineral Density in Childhood Study

Zemel Babette , Kalkwarf Heidi , Leonard Mary , Gilsanz Vicente , Lappe Joan , Shults Justine , Shepherd John , Oberfield Sharon , Winer Karen

Objective: Total body less head (TBLH) and spine are the recommended DXA sites for bone health assessment in children and adolescents. However, inter-machine differences will affect use and interpretation of results in clinical care and research applications. We examined BMC and areal-BMD (aBMD) at 4 skeletal sites among healthy children to identify the magnitude of inter-machine differences in Z-scores.Methods: BMDCS evaluated healthy participa...

ba0002oc29 | Chronic diseases | ICCBH2013

Mineral metabolism, cortical volumetric bone mineral density and fracture risk in childhood chronic kidney disease

Denburg Michelle , Tsampalieros Anne , de Boer Ian , Shults Justine , Kalkwarf Heidi , Zemel Babette , Foerster Debbie , Stokes David , Leonard Mary

Background and Objectives: The relations among cortical volumetric bone mineral density (CortBMD) and comprehensive measures of mineral metabolism have not been addressed in chronic kidney disease (CKD). The aim was to identify determinants of CortBMD in childhood CKD. A secondary objective was to assess if CortBMD was associated with subsequent fracture.Design/participants: This prospective cohort study in children, adolescents and young adults (ages 5&...

ba0007p164 | (1) | ICCBH2019

Musculoskeletal deficits persist up to two years despite anti-TNF-alpha antibody therapy in children with Crohn's disease: Results of a prospective, observational inception cohort study

Jackowski Stefan A , Ma Jinhui , Benchimol Eric I , Rauch Frank , Leonard Mary B , Zemel Babette S , Matzinger Mary Ann , Shenouda Nazih , Lentle Brian , Jaremko Jacob L , Khatchadourian Karine , Robinson Marie-Eve , Konji Victor N , Siminoski Kerry , Mack David , Ward Leanne M

Objectives: To evaluate musculoskeletal trajectories in children with newly diagnosed Crohn’s disease (CD), and to determine whether children treated with anti-tumour necrosis factor-alpha antibody (anti-TNF, TREATED vs NAÏVE) had persistent deficits at two years.Methods: This was a single-centre prospective, observational inception cohort study. Children with CD underwent assessments within 6.5±9.5 days from diagnosis and annually for two...