Searchable abstracts of presentations at key conferences on calcified tissues

ba0004p13 | (1) | ICCBH2015

Galactosyltransferase-1 deficiency: a novel cause of bone fragility due to impaired proteoglycan synthesis

Moon Rebecca , Salter Claire , Foulds Nicola , Davies Justin

Proteoglycans is a component of extracellular matrix, forming a mesh around structural proteins including collagen and elastin, and providing elasticity to tissue structure. Proteoglycans is formed by the attachment of glycosaminoglycans to a core protein, a process that requires three enzymes: galactosyltransferase-1, galactosyltransferase-2 and glucoronosyltransferase-1, encoded by B4GALT7, B3GALT6 and B3GAT3 respectively. B3GALT6 mutation...

ba0006p152 | (1) | ICCBH2017

Seasonal variation in internet searches for vitamin D

Moon Rebecca , Curtis Elizabeth , Davies Justin , Cooper Cyrus , Harvey Nicholas

Objective: Over the last decade, there has been increasing scientific interest in vitamin D, and it is now advised that all pregnant women and infants should receive vitamin D supplementation. Despite of this, it is recognized that knowledge of vitamin D in the general public is limited. The internet is now an important source of health care information and analysis of internet search activity rates can provide information on disease epidemiology, health related behaviors and ...

ba0007p167 | (1) | ICCBH2019

Children's multivitamins do not contain sufficient vitamin D

Moon Rebecca , Curtis Elizabeth , Cooper Cyrus , Davies Justin , Harvey Nicholas

Objective: Public Health England recommends that children in the United Kingdom (UK) aged over 1 year should take a vitamin D supplement containing 400 IU/day. Commercially available children’s multivitamin and vitamin D supplements were surveyed to determine the vitamin D content.Methods: Multivitamins and vitamin D supplements marketed at children <12 years and sold by nine UK supermarkets and health supplement retailers were surveyed. The vit...

ba0002op6 | (1) | ICCBH2013

Children with nephrotic syndrome have increased tibial bone area but similar volumetric bone mineral density to healthy controls

Moon Rebecca , Gilbert Rodney , Page Anna , Murphy Liam , Taylor Pat , Cooper Cyrus , Dennison Elaine , Davies Justin

Objectives: An increased fracture risk is reported in children requiring recurrent courses of glucocorticoids. Reduced bone mineral density (BMD), particularly in the trabecular compartment, has also been demonstrated in a number of childhood diseases treated with glucocorticoids. The differential contribution of glucocorticoids and underlying inflammatory disease to bone demineralisation is poorly understood. Childhood nephrotic syndrome (NS) often follows a relapsing-remitti...

ba0004p14 | (1) | ICCBH2015

Accuracy of parental recall of children's lifetime fracture prevalence: implications for investigation of childhood osteoporosis

Moon Rebecca , Lim Adelynn , Farmer Megan , Segaran Avinash , Clarke Nicolas , Davies Justin

Fractures are common in childhood, but multiple fractures during growth could indicate osteoporosis. Children with frequent fractures might benefit from further investigations for osteoporosis and as such, obtaining an accurate fracture history is important. The 2013 International Society for Clinical Densitometry Paediatric Osteoporosis Position Statement defined a clinically significant fracture history as two long bone fractures before age 10 years or three long bo...

ba0007p5 | (1) | ICCBH2019

Response of bone to mechanical stimulation in the offspring of MAVIDOS study mothers in a single centre; the effect of antenatal vitamin D supplementation

Gopal Sujatha , Rigby Alan , Moon Rebecca , Cooper Cyrus , Harvey Nick , Harrison Rachel , Bishop Nick

Background: Preclinical model studies suggest early life vitamin D depletion reduces bone’s response to mechanical loading. The MAVIDOS trial (randomised placebo controlled trial of vitamin D supplementation in pregnancy) reported winter-born infants of mothers receiving vitamin D supplementation had higher bone mass; the earlier Southampton Princess Ann Cohort study linked pregnancy blood vitamin D levels to later bone mass and size. We showed previously that bone respon...

ba0007p22 | (1) | ICCBH2019

Tibia microarchitecture in children with recent fractures

Moon Rebecca , Gillespie Tom , Quiney Naomi , Cooper Cyrus , Harvey Nicholas , Davies Justin

Objectives: Children who fracture have lower bone mineral density (BMD) measured by dual energy X-ray absorptiometry (DXA) than children who do not sustain fractures, but there is little data on bone microarchitecture in relation to childhood fracture. We assessed tibia microarchitecture using high resolution peripheral quantitative computed tomography (HR-pQCT) in children with recent fracture and those without a history of fracture.Methods: Children ag...

ba0007p154 | (1) | ICCBH2019

Self-reported sedentary time is negatively associated with microarchitecture of the tibia

Moon Rebecca , Gillespie Tom , Quiney Naomi , Cooper Cyrus , Harvey Nicholas , Davies Justin

Objectives: Weight bearing physical activity (PA) is thought to be beneficial to bone mineral accrual in childhood, but the influence of PA and sedentary time on bone microarchitecture is less well described. We examined the relationships between self-reported PA and volumetric bone mineral density (vBMD) and bone microarchitecture at the distal tibia, assessed using high resolution peripheral quantitative computed tomography (HR-pQCT).Methods: Healthy c...

ba0002oc4 | Epidemiology | ICCBH2013

Maternal antenatal 25(OH)-vitamin D status is associated with offspring muscle strength at 4 years of age

Moon Rebecca , Sayer Avan A , Ntani Georgia , Davies Justin , Robinson Sian , Godfrey Keith , Inskip Hazel , Cooper Cyrus , Harvey Nicholas

Objectives: Serum 25(OH)-vitamin D (25(OH)D) concentration is known to influence muscle function in postnatal life. Maternal 25(OH)D status during pregnancy has been implicated in the fetal programming of bone and fat mass, but little is known about its role in determining offspring muscle development. We investigated the associations between maternal serum 25(OH)D concentration in pregnancy and offspring muscle mass and strength at 4 years.Materials and...

ba0004op10 | (1) | ICCBH2015

Does degree of adiposity influence upper limb fracture site in children?

Moon Rebecca , Lim Adelynn , Farmer Megan , Segaran Avinash , Clarke Nicholas , Harvey Nicholas , Dennison Elaine , Cooper Cyrus , Davies Justin

Although it has been suggested that overweight and obese children have an increased risk of fracture, recent studies in post-menopausal women have shown that the relationship between obesity and fracture risk varies by fracture site. Thus, obesity is protective against wrist fractures but confers an increased risk of humeral fractures. There are no data to suggest whether this observation is also present in children. We therefore assessed whether adiposity and overweight/obesi...