Searchable abstracts of presentations at key conferences on calcified tissues

ba0006p208 | (1) | ICCBH2017

Social barriers and needs of children with osteogenesis imperfecta (OI): a qualitative descriptive interview-based study

Konstantynowicz Jerzy , Abramowicz Pawel

Objective: Osteogenesis imperfecta (OI) which is a heterogenic group of diseases presenting with bone fragility, skeletal deformations and limited mobility may confer a risk of several non-skeletal health issues and is associated with adaptational social problems. The aim of the qualitative descriptive study was to determine the most important areas (problems?) related to social functioning, familial environment, hospital amenities and social needs in children with OI.<p c...

ba0004p104 | (1) | ICCBH2015

Effect of intravenous pamidronate in the treatment of skin calcinosis in the course of juvenile dermatomyositis -- a story half-told

Abramowicz Pawel , Dobrenko Elzbieta , Abramowicz Magdalena , Konstantynowicz Jerzy

Juvenile dermatomyositis (JDM) is a severe connective-tissue disease of unknown etiology characterized by inflammatory process affecting muscles and skin, with subsequent presentation in the joints, esophagus, lungs, and the cardiovascular system. Clinical presentation also includes deposition of calcium in the skin (calcinosis cutis) which is typically seen in the juvenile DM, contrary to the adult form. The pathogenesis of JDM-related calcinosis remains unclear wher...

ba0006p071 | (1) | ICCBH2017

In search of hypophosphatasia: a need to establish normative data for low alkaline phosphatase in pediatric population

Abramowicz Pawel , Konstantynowicz Jerzy , Zelazowska-Rutkowska Beata , Cylwik Bogdan

Background: Hypophosphatasia (HPP) is a rare inborn error of metabolism caused by mutations in the gene encoding tissue-nonspecific alkaline phosphatase gene (TNSALP), leading to low alkaline phosphatase (ALP) activity. At least 6 clinical forms of HPP have been reported. Certain benign or asymptomatic presentations of HPP in older children may remain undiagnosed, in contrast to severe perinatal and infantile types. The underlying reason of this diagnostic inconsisten...

ba0007p186 | (1) | ICCBH2019

Severe osteoporosis with life threatening vertebral fractures in a 15-years-old boy with juvenile idiopathic arthritis: a successful spinal cord decompression and posterior spinal fusion Th2-Th12

Abramowicz Pawel , Grabala Pawel , Guszczyn Tomasz , Stawicki Maciej , Konstantynowicz Jerzy

Background: Chronic rheumatic conditions including juvenile idiopathic arthritis (JIA) lead to the deterioration of bone mineral metabolism and confers risk of fragility fractures. Although contemporary medical therapies have limited skeletal complications in JIA, some rare cases of severe osteoporosis are still reported in these patients. Systemic glucocorticoid (GCS), long-term inflammation, and disease-related immobility are responsible to skeletal damage in JIA.<p clas...

ba0002p40 | (1) | ICCBH2013

Altered bone metabolism in obese children: the pathogenic role of adipocytokines and inflammation

Abramowicz Pawel , Konstantynowicz Jerzy , Werpachowska Irena , Jamiolkowski Jacek , Kaczmarski Maciej , Piotrowska-Jastrzebska Janina

Objective: Associations between childhood obesity and disturbed bone metabolism have been extensively studied. Both RANK/RANKL/OPG and adipocytokines are involved in bone metabolism in obese individuals although published data remain inconsistent. Some reports show evidence of protective role of adiposity in the maintenance of skeletal mass, whereas others fail to support this evidence or even demonstrate an increased fragility. The aim of the study was to assess bone metaboli...

ba0002p99 | (1) | ICCBH2013

Potential association between vitamin D deficiency and hypertension in adolescents: a Pilot study

Babinska-Malec Edyta , Konstantynowicz Jerzy , Abramowicz Pawel , Werpachowska Irena , Bazyluk-Muszynska Malgorzata , Piotrowska-Jastrzebska Janina

Objective: Insuficient vitamin D supply defined as serum hydroxyvitamin D (25OHD) <20 ng/ml is considered as one of possibile cardiovascular risk factors among adults with hypertension. Furthermore, some data also suggest an independent association between vitamin D deficits and hypertension and obesity during growth. The aim of the study was to assess vitamin D status in children and adolescents with hypertension.Methods: The cross sectional study w...

ba0002p153 | (1) | ICCBH2013

Low urinary citrate: a risk factor for fragility fractures in children and adolescents

Konstantynowicz Jarzy , Porowski Tadeusz , Abramowicz Pawel , Bialokoz-Kalinowska Irena , Piotrowska-Jastrzebska Janina

Objectives: Idiopathic hypercalciuria may infer not only an increased risk of nephrolithiasis but may also be associated with reduced bone mineral density (BMD) in adults. However, little is known about relationships between hypercalciuria, oxaluria, urolithiasis, citraturia and fracture risk in children. The aim of this cross-sectional study was to evaluate associations between hypercalciuria, urinary oxalate and citrate, BMD and fractures in hypercalciuric children.<p cl...

ba0004p183 | (1) | ICCBH2015

Deficits of vitamin D are strongly associated with methotrexate treatment in patients with juvenile idiopathic arthritis

Goralczyk Adrian , Konstantynowicz Jerzy , Abramowicz Pawel , Dobrenko Elzbieta , Babinska-Malec Edyta

Vitamin D deficiency has been reported in adult patients with autoimmune diseases including rheumatoid arthritis, however, the data in patients with juvenile idiopathic arthritis (JIA) are inconsistent. The aim of the study was to assess serum 25-hydroxyvitamin D (25(OH) D in children and adolescents with JIA, and to determine potential risk factors for vitamin D deficiency.In this cross-sectional study, we evaluated 189 patients with JIA (113 girls, 76 ...