Searchable abstracts of presentations at key conferences on calcified tissues

ba0002oc14 | Diagnostics | ICCBH2013

What DXA measurement sites are best for bone health assessment in children? Effect of inter-machine differences on bone outcomes from the Bone Mineral Density in Childhood Study

Zemel Babette , Kalkwarf Heidi , Leonard Mary , Gilsanz Vicente , Lappe Joan , Shults Justine , Shepherd John , Oberfield Sharon , Winer Karen

Objective: Total body less head (TBLH) and spine are the recommended DXA sites for bone health assessment in children and adolescents. However, inter-machine differences will affect use and interpretation of results in clinical care and research applications. We examined BMC and areal-BMD (aBMD) at 4 skeletal sites among healthy children to identify the magnitude of inter-machine differences in Z-scores.Methods: BMDCS evaluated healthy participa...

ba0002p156 | (1) | ICCBH2013

Reflection analysis of infant scans results may improve infant DXA bone density and body composition result that contain motion

Shepherd John , Fan Bo , Powers Cassidy , Stranix-Chibanda Lynda , Fowler Mary , DiMeglio Linda , George Kathy , Siberry George

Objectives: Special dual-energy X-ray absorptiometry (DXA) protocols permit quantification of bone mineralization, fat mass, and fat distribution in infants. Our objective was to evaluate the accuracy and precision of a multiscan acquisition protocol designed to allow for reflection and imputation analysis for regions with movement.Methods: The IMPAACT P1084s Study assesses bone and kidney safety of antiretrovirals used for PMTCT. Newborns received a spi...

ba0002p18 | (1) | ICCBH2013

Influence of anthropometric parameters on assessment of paediatric bone mineral density and bone mineral content

Hangartner Thomas N , Short David F , Gilsanz Vicente , Kalkwarf Heidi J , Lappe Joan M , Oberfield Sharon , Shepherd John A , Zemel Babette S , Winer Karen

Objectives: Creation of reference curves for areal bone mineral density (aBMD) and bone mineral content (BMC) with consideration of relevant anthropometric variables.Methods: Analysis of the dual-energy X-ray absorptiometry (DXA) data collected as part of the Bone Mineral Density in Childhood Study1, including 2012 boys and girls, 5–22 years old, with a total of 10 525 visits, resulting in aBMD and BMC observations at the lumbar spine, hi...

ba0006oc3 | (1) | ICCBH2017

Principal component-derived bone density phenotypes and genetic regulation of the pediatric skeleton

Mitchell Jonathan , Chesi Alessandra , McCormack Shana , Cousminer Diana , Kalkwarf Heidi , Lappe Joan , Gilsanz Vicente , Oberfield Sharon , Shepherd John , Kelly Andrea , Zemel Babette , Grant Struan

Objectives: To determine if genetic variants associated with principal component-derived areal bone mineral density (aBMD) loading scores.Methods: Our sample comprised 1,293 children of European ancestry enrolled in the longitudinal Bone Mineral Density in Childhood Study (52% female). The participants completed up to 7 annual study visits. From dual energy X-ray absorptiometry scans, sex and age-specific aBMD Z-scores were calculated for total hip, femo...

ba0007p94 | (1) | ICCBH2019

Characteristics of ultradistal radius bone density during childhood: results from the Bone Mineral Density in Childhood Study

Kindler Joseph , Mitchell Jonathan , McCormack Shana , Cousminer Diana , Chesi Alessandra , Kelly Andrea , Lappe Joan , Gilsanz Vicente , Oberfield Sharon , Shepherd John , Winer Karen , Kalkwarf Heidi , Grant Struan , Zemel Babette

Objective: The forearm is a common fracture site during childhood, but DXA pediatric reference data for areal bone mineral density (aBMD) at the ultradistal (UD) radius are lacking. The objective of this study was to first, develop age-, sex-, and ancestry-specific reference data for UD radius aBMD; second, assess the relationship between UD radius aBMD and a) other DXA aBMD measures and b) radius bone volumetric density and geometry by pQCT; and third, examine the tracking of...

ba0002oc6 | Epidemiology | ICCBH2013

Role of bone-associated loci identified in GWAS meta-analyses in the context of longitudinal pediatric BMD in European Americans

Zemel Babette , Kalkwarf Heidi , Li Mingyao , Deliard Sandra , Kim Celia , Qu Liming , Chiavacci Rosetta , Paulhamus Donna , Lappe Joan , Gilsanz Vicente , Hakonarson Hakon , Oberfield Sharon , Shepherd John , Voight Ben , Kelly Andrea , Grant Struan

Objective: With recent genome wide association studies (GWAS), ~70 loci have been robustly and reproducibly associated with adult bone density and/or osteoporosis. However, to date no systematic effort has investigated which of these loci operate early in life. We investigated whether these single nucleotide polymorphisms (SNPs) are associated with childhood areal bone mineral density (aBMD). In addition we determined if any of the associations were age dependent.<p class=...