Searchable abstracts of presentations at key conferences on calcified tissues

ba0007p147 | (1) | ICCBH2019

Changes in DXA Z-scores during bisphosphonate (BP) therapy in patients with osteogenesis imperfecta (OI) at a tertiary care hospital in South Africa

Siralarala Akhona , Pettifor John Morley , Thandrayen Kebashni

Objectives: The aim of this study was to evaluate and assess the change in bone mineral density in OI children treated with BPs at Chris Hani Baragwanath Academic hospital (CHBAH), South Africa.Methods: Medical files of 104 OI patients who were seen at Metabolic Bone clinic from 01 January 2006 till 31 December 2015 were reviewed. DXA measurements were available on 33 patients that received bisphosphonates from baseline and during therapy at three time p...

ba0002oc2 | Epidemiology | ICCBH2013

Fracture patterns and bone mass in South African adolescent–mother pairs: the Birth to Twenty Cohort

Thandrayen Kebashni , Norris Shane , Micklesfield Lisa , Pettifor John

Differences in fracture rates and bone mass in families and individuals of different ethnic origins may be due to differing lifestyles and/or genetic backgrounds. This study aimed to assess the associations of bone mass and fracture prevalence in adolescents with maternal bone mass and fracture history, and sibling fracture history.Data from 1389 adolescent-biological mother pairs from the Birth to Twenty (Bt20) longitudinal study were obtained. Question...

ba0006p066 | (1) | ICCBH2017

Unusual presentation of acquired hypophosphataemic rickets

Thandrayen Kebashni , Parbhoo Kiran , Moosa Fatima , Pettifor John

Background: Acquired hypophosphataemic rickets is an unusual presentation in children and usually consequent on renal tubular damage. One of the factors important in phosphate homeostasis is FGF23. Healthy individuals maintain normal phosphate homeostasis by coupling FGF23 production with proteolytic cleavage. Iron deficiency stimulates FGF23 transcription and is a novel mechanism of FGF23 elevation. We present two children who presented with iron deficiency anaemia and hypoph...

ba0004p188 | (1) | ICCBH2015

Fractures, bone mass and geometry in black and white South African children: The Birth to Twenty cohort

Thandrayen Kebashni , Schoenbuchner Simon , Ward Kate , Micklesfield Lisa , Norris Shane , Prentice Ann , Pettifor John

The prevalence of fractures in white children in South Africa is double that of black children (1). White males who fractured were shown to be more physically (2). The aim of this study was to compare the bone mass and geometry measures using peripheral quantitative computed tomography (pQCT) and dual energy x-ray absorptiometry (DXA) in black and white children with and without a history of fracture to determine the risk factors for fractures.Lifetime f...

ba0007p44 | (1) | ICCBH2019

Bone mass and vertebral fractures in South African (SA) children on prolonged oral glucocorticoids (GCs) for chronic non-malignant illnesses

Thandrayen Kebashni , Petersen Karen , Kala Udai , Lala Nilesh , Ambaram Priya , Mistry Bhadrish , Hauptfleisch Marc , Hajinicolaou Christina , Okudu Grace , Verwey Charl , Moosa Fatima , Parbhoo Kiran , Pettifor John M

Objectives: To assess lumbar spine (LS) BMD Z-scores and the prevalence of vertebral fractures using DXA lateral vertebral (VFA) assessment in children and adolescents with chronic illnesses on GCs.Methods: All children between the ages of 5 and 17 years with chronic non-malignant illnesses who were on GCs (intravenous or oral) for greater than 3 months duration were evaluated. Study participants were children attending the paediatric sub-specia...

ba0007oc9 | (1) | ICCBH2019

Efficacy and safety of intravenous zoledronic acid for the treatment of pediatric glucocorticoid-induced osteoporosis: An international, randomized placebo-controlled trial

Ward Leanne M , Alos Nathalie , Cabral David A , Rodd Celia , Sbrocchi Anne Marie , Padidela Raja , Shaw Nick , Kostik Mikhail , Alexeeva Ekaterina , Thandrayen Kebashni , Aftring Paul , Choudhury Anup , Sunkara Gangadhar , Sayyed Sarfaraz , Munns Craig F.

Objectives: We evaluated the efficacy and safety of intravenous zoledronic acid (IV ZA) in children with glucocorticoid-induced osteoporosis (GIOP) through a randomized, placebo (PBO)-controlled trial.Methods: In this multi-national Phase 3 trial (NCT00799266), children 5–17 years of age with GIOP and low-trauma vertebral fractures (VF) were randomized 1:1 to IV ZA 0.05 mg/kg or IV PBO every six months for one year. Changes in lumbar spine areal bon...