Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p492 | Steroid hormones and receptors | ECTS2016

Distinct glucocorticoid receptor functions during inflammation and osteoporosis

Tuckermann Jan

Glucocorticoids (GCs) are widely used to treat acute and chronic inflammatory diseases such as acute lung injury (ALI) and rheumatoid arthritis (RA) and lead to multiple side effects including GC induced osteoporosis (GIO). Molecularly GCs act by binding to the GC receptor (GR), a ligand induced transcription factor. We discovered that pharmacologically GC exposure reprograms binding of GR monomers towards GR dimers (Genome Research 2015 25:836). Furthermore we challenged the ...

ba0001oc4.4 | Osteoblasts and osteocytes | ECTS2013

Glucocorticoid exposure reduces expression of sclerostin in bone marrow stromal cells

Thiele Sylvia , Rauch Alexander , Tuckermann Jan P , Hofbauer Lorenz C , Rauner Martina

Glucocorticoids (GC) are effective drugs in the treatment of inflammatory diseases, including various forms of arthritis. However, their use is limited by negative effects on bone mass and strength, resulting in increased osteoporotic fractures. Conditional knockout mice demonstrated that the GR in osteoblasts is essential for GC-dependent bone loss. Recent studies show that GC profoundly inhibit Wnt signaling by stimulating the expression of Wnt antagonists such as dickkopf-1...

ba0001pp510 | Steroid hormones and receptors | ECTS2013

Glucocorticoids inhibit bone formation independent of miRNA regulation

Liu Peng , Baschant Ulrike , Groth Marco , Baumgart Mario , Platzer Matthias , Jack Hans-Martin , Tuckermann Jan

: Glucocorticoid-induced osteoporosis (GIO) is the most frequent secondary osteoporosis in patients undergoing steroid therapy.Recently we demonstrated that the inhibition of bone formation in GIO is occurring in part via the suppression of autocrine cytokines by the glucocorticoid receptor (GR) monomer in osteoblasts (Cell Metab 11, 517–531). Since emerging evidences indicate that microRNAs (miRNAs) play a critical role in the differentiat...

ba0003pp414 | Steroid hormones and receptors | ECTS2014

Glucocorticoids suppress inflammation in arthritis via the glucocorticoid receptor in non-hematopoietic cells

Baschant Ulrike , Culemann Stephan , Koenen Mascha , Zhou Hong , Seibel Markus , Hofbauer Lorenz , Tuckermann Jan

Owing to their anti-inflammatory effects, steroid therapy using glucocorticoids (GCs) is still part of the treatment of rheumatoid arthritis (RA), despite several severe side effects like glucocorticoid-induced osteoporosis (GIO). Until now the molecular mechanisms underlying the beneficial and side effects of GC therapy are poorly understood. GCs exert their actions via the glucocorticoid receptor (GR) that alters gene expression by either binding as a dimer to GC response el...

ba0005p118 | Cancer and bone: basic, translational and clinical | ECTS2016

Menin is a tumor suppressor in bone -- a novel benign jaw tumor mouse model

Lee Sooyeon , Liu Peng , Tschaffon Miriam , Tasdogan Alpaslan , Wittig Rainer , Frappart Lucien , Knoll Jeanette , Bertolino Philippe , Zhang Chang , Tuckermann Jan

Benign jaw tumors including ossifying fibroma (OF) can be often incidentally diagnosed due to their slow-growing and painless characteristics. In cases of massive growing jaw tumors, it can result in deformity of teeth, infection and intracranial complications. Depending on the location of tumor lesion, it may not completely resected and recur after the primary operation, which may require subsequent operations.Molecular mechanisms and the etiology of th...

ba0003pp416 | Steroid hormones and receptors | ECTS2014

Novel mechanisms of action and new target genes of the glucocorticoid receptor in inflammatory bone disease and bone loss

Baschant Ulrike , Ahmad Mubashir , Koenen Mascha , Knoll Jeanette , Culemann Stephan , Schauer Sebastian , Bauer Kerstin , Wittig-Blaich Stephanie , Rauch Alexander , Kronke Gehrhard , Dudeck Anne , David Jean-Pierre , Rauner Martina , Seibel Markus , Ploubidou Aspasia , Zhou Hong , Hofbauer Lorenz , Tuckermann Jan

Glucocorticoids (GCs) are widely used to treat chronic inflammatory diseases such as rheumatoid (RA) and lead to multiple side effects including glucocorticoid induced osteoporosis (GIO). Our work challenges the dogma that transrepression of pro-inflammatory genes by the glucocorticoid receptor (GR) is solely responsible for reducing inflammation, whereas transactivation of genes is causing side effects.Using conditional and function selective mutant mic...