Searchable abstracts of presentations at key conferences on calcified tissues

ba0001oc1.5 | Osteoporosis epidemiology and long term treatment complications | ECTS2013

Heart failure in patients treated with bisphosphonates

Grove Erik , Abrahamsen Bo , Vestergaard Peter

Background: Bisphosphonates are widely used to prevent and treat osteoporosis. Limited evidence suggest that these drugs may reduce mortality, perhaps by protecting against cardiovascular disease. This study investigated the occurrence of heart failure in patients treated with bisphosphonates.Methods: Nationwide retrospective cohort study from Denmark. All users of bisphosphonates and raloxifene (n=4.831) between 1996 and 2006 (n=102.34...

ba0003oc6.6 | Osteoporosis treatment and the effects of physical activity | ECTS2014

External auditory canal and middle ear diseases in bisphosphonate-treated osteoporosis patients: A Danish national register based cohort study

Thorsteinsson Anne-Luise , Vestergaard Peter , Eiken Pia

Background and aim: Eight cases of bisphosphonate-associated osteonecrosis of the external auditory canal have been reported in case-reports. Our aim was to describe the incidence of external auditory canal and middle ear diseases in Danish patients exposed to bisphosphonates in the treatment of osteoporosis.Methods: The study was a retrospective, nationwide cohort study, within the Danish population of approximately 5.6 million individuals and based on ...

ba0001pp109 | Calciotropic and phosphotropic hormones and mineral metabolism | ECTS2013

Biochemical bone markers of bone turnover in diabetics: a meta-analysis

Starup-Linde Jakob , Eriksen Stine Aistrup , Vestergaard Peter

Introduction: Diabetes mellitus may affect bone via bone structure, bone density, and biochemical markers of bone turnover. The aim of this meta-analysis was to examine biochemical markers of bone turnover in diabetics compared to non-diabetics.Methods: A systematic literature search was conducted using Pubmed, Embase, Cinahl, and Svemed+ with the search terms: ‘Diabetes mellitus’, ‘Diabetes mellitus type 1’, ‘Insulin dependent d...

ba0001pp315 | Osteoporosis: evaluation and imaging | ECTS2013

The stability of intact parathyroid hormone in human blood during different sampling conditions and long-term storage in serum tubes

Andersen Camilla Sand , Hoeck Hans Christian , Gazerani Parisa , Vestergaard Peter

Objective: To investigate i) the analytic stability of PTH in venous blood specimens in serum tubes processed at different time intervals after collection compared to immediately processed blood samples collected in K2EDTA tubes, and ii) whether storage of samples in serum tubes for 5 years at −20 °C had an effect on stability of PTH.Methods: Venous blood samples were collected from ten healthy Caucasian females. One K2EDTA tube and three seru...

ba0001pp399 | Osteoporosis: treatment | ECTS2013

Assessment of serum 25-hydroxyvitamin D concentrations in postmenopausal osteoporotic women: a retrospective study to evaluate long-term treatment with vitamin D3

Andersen Camilla Sand , Vestergaard Peter , Gazerani Parisa , Hoeck Hans Christian

Introduction: The purpose of this study was to evaluate whether daily treatment with 400 IU vitamin D3 was sufficient to maintain 25-hydroxyvitamin D (25(OH)D) concentrations above 60 nmol/l over a 3-year period. In addition, the study aimed to clarify if any differences existed in serum 25(OH)D between pre-supplemented women and women who already had serum 25(OH)D above 60 nmol/l at screening.Methods: Serum samples drawn from 251 postmenopaus...

ba0003pp210 | Muscle, physical activity and bone | ECTS2014

No beneficial effects of vitamin D supplementation in muscle function or quality of life in primary hyperparathyroidism: results from a randomized controlled trial

Rolighed Lars , Rejnmark Lars , Sikjaer Tanja , Heickendorff Lene , Vestergaard Peter , Mosekilde Leif , Christiansen Peer

Context: Impairment of muscle function and strength in patients with primary hyperparathyroidism (PHPT) is rarely addressed although decreased muscle function may contribute to increased fracture risk in PHPT.Objective: We aimed to assess changes in muscle strength, muscle function, postural balance, quality of life (QoL), and well-being during treatment with vitamin D or placebo before and after parathyroidectomy (PTX) in PHPT patients.<p class="abs...

ba0003pp301 | Osteoporosis: treatment | ECTS2014

Effect of gastrointestinal events on treatment patterns, discontinuation, resource utilization, and cost in osteoporosis: an analysis using danish health registries

Kjellberg Jakob , Jorgensen Andreas D , Vestergaard Peter , Ibsen Rikke , Krishna Arun

Objectives: To investigate the burden and impact of gastrointestinal (GI) events in osteoporosis (OP) patients by i) examining the association of GI events with the likelihood of OP treatment initiation; ii) measuring the effect of GI events on treatment discontinuation; and iii) determining the impact of GI events post-OP treatment on health care resource utilization and cost. All subjects are identified utilizing national health registries which cover the whole Danish popula...

ba0005oc3.3 | Clinical trials, FGF-23 and focal osteoporosis | ECTS2016

Vitamin D supplementation reduces pregnancy chances: a randomized, placebo-controlled trial

Rasmussen Gitte Bloch , Mosekilde Leif , Vestergaard Peter , Heickendorff Lene , Ulbjerg Niels , Langdahl Bente , Rejnmark Lars

Introduction: Low 25-hydroxyvitamin D (25OHD) levels are frequently found in fertile women and associated with low birth weight, reduced fertility and adverse pregnancy outcomes.Objective: We investigated the effects of vitamin D supplementation on birth weight, fertility, and delivery complications in women planning pregnancy with low 25OHD levels.Methods: This was an investigator-initiated double-blind, randomized, placebo-contro...

ba0005p275 | Nutrition | ECTS2016

Vitamin D from the marine inuit diet and markers of inflammation – a population-based survey in Greenland

Schaebel Louise , Bonefeld-Jorgensen Eva , Laurberg Peter , Vestergaard Henrik , Andersen Stig

Background: The traditional Inuit diet in Greenland consists mainly of fish and marine mammals. The marine diet is an important source for vitamin D in Greenland. Vitamin D has anti-inflammatory capacity but markers of inflammation were high in Inuit with a high intake of marine food items. Yet, the effect of vitamin D on inflammation in Inuit remains unsettled.Objectives: To investigate the association between vitamin D and markers of inflammation in a ...