Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp444 | Osteoporosis: treatment | ECTS2013

Correction of vitamin D deficiency in women with postmenopausal osteoporosis

Povoroznyuk Vladyslav , Balatska Nataliya

The aim of the research: To investigate the effect of combined calcium and vitamin D therapy (calcium 1000 mg, vitamin D 400 IU) on 25(OH)D level and concentration of bone turnover markers in patients with systemic postmenopausal osteoporosis.Methods: 20 women with systemic postmenopausal osteoporosis were examined. The average age of the patients was (63.0 (59.00; 68.00)) years. The study was performed during winter season to exclude the influence of se...

ba0003pp279 | Osteoporosis: pathophysiology and epidemiology | ECTS2014

Influence of vitamin D deficiency on bone turnover markers in men of different age

Balatska Nataliya , Povoroznyuk Vladyslav

Introduction: Optimal 25(OH)D serum level is very important for bone health and calcium–phosphate homeostasis as well as for optimal function of many organs and tissues. The consequences of vitamin D deficiency are mineralization defects, which may lead to osteomalacia in the long-term, and muscle weakness, causing falls and fractures.Objectives: The aim of the research is to determine the frequency of vitamin D deficiency and it’s influence on...

ba0006p129 | (1) | ICCBH2017

The case of severe osteoporosis in patient with recessive dystrophic Epidermolysis Bullosa

Balatska Nataliya , Povoroznyuk Vladyslav

Background: Epidermolysis bullosa (BE) is a group of inherited diseases that are characterized by skin and mucosal fragility and blister formation. The various complications such as malnutrition, anemia, growth retardation, esophageal stenosis and deformities may develop. Low bone mass and fractures recognized as complications of generalized forms of EB.Presenting problem: In the Ukrainian medical center of osteoporosis there were examined nine children ...

ba0001pp445 | Osteoporosis: treatment | ECTS2013

Effectiveness of the active metabolite of vitamin D in the treatment of postmenopausal osteoporosis

Klimovitskiy Fedir , Povoroznyuk Vladyslav , Balatska Nataliya

The aim of the research was to determine the efficacy of alfacalcidol (Alpha D3 Teva) in the treatment of women with postmenopausal osteoporosis and vitamin D deficiency.Methods: 20 women with systemic postmenopausal osteoporosis were examined. All patients had vitamin D deficiency (the average level of 25(OH)D in blood serum was (37.16 (24.9, 45.1)) nmol/l). Alfacalcidol was prescribed for 12 month in doses 1 μg. duration of observation was 12 mont...

ba0004p86 | (1) | ICCBH2015

Caries intensity and bone mineral density in children living in fluorine deficient region

Povoroznyuk Vladyslav , Zadorozhna Iryna , Balatska Nataliya

Objectives: Evaluation of influence the structural and functional condition of bone tissue on caries intensity in adolescents living with deficient of fluoride in drinking water (<0.4 mg/l).Methods: It was examined 200 school children (12 and 15 years old) living in Transcarpathian region.Oral examination was done to determine caries intensity in the subjects (DMFT-index). Bone quality was determined using quantitative ultrasou...

ba0005p467 | Other diseases of bone and mineral metabolism | ECTS2016

Disease activity in patients with rheumatoid arthritis according to vitamin D status

Balatska Nataliya , Synenky Omelyan , Povoroznyuk Vladyslav

Introduction: Vitamin D deficiency is common in patients with rheumatoid arthritis and may be related to disease activity.The aim of the study was to evaluate the association between 25(OH)D level and disease activity in patients with rheumatoid arthritis.Materials and methods: The study included 61 patients with rheumatoid arthritis, 73.8% were women, 70.4 patients were younger 60 years old. Subjects suffering from liver and kidne...

ba0003pp281 | Osteoporosis: pathophysiology and epidemiology | ECTS2014

State of vitamin D sufficiency Ukrainian schoolchildren

Povoroznyuk Vladyslav , Balatska Nataliya , Budnik Tetyana , Erokchina O

Background: It is now known that the osteoporosis starts developing childhood. Children’s age is characterized by intensive accumulation of bone mass. By the end of puberty the level of bone mass in many parts of the skeleton reaches 86% of the bone mass of an adult and in some parts it reaches 100%.The processes of bone metabolism closely connected with the level of the vitamin D, in the body because it has a pronounced effect on calcium homeostasi...

ba0005p254 | Genetics and Epigenetics | ECTS2016

Genetic risk factors for knee osteoarthritis in postmenopausal ukrainian women

Grygorieva Nataliia , Povoroznyuk Vladyslav , Kaliada Aleksander , Krochak Svyatoslava , Balatska Nataliya

Osteoarthritis is a complex pathogenesis because diverse factors interact causing a process of deterioration of the cartilage and the subchondral bone. Despite the multifactorial nature of the knee osteoarthritis, it is related to a strong genetic component. Determination of molecular genetic causes of osteoarthritis is an actual problem. There are several approaches to assess the contribution of a candidate gene in the pathogenesis of osteoarthritis. The aim of the study was ...

ba0005p255 | Genetics and Epigenetics | ECTS2016

Polymorphism of vitamin D receptor gene, estrogen receptor gene and collagen type I α1 gene for osteoporosis in Ukrainian women

Balatska Nataliya , Povoroznyuk Vladyslav , Grygorieva Nataliia , Kaliada Aleksander

Osteoporosis has a complex etiology and is considered a multifactorial polygenic disease in which genetic determinants are modulated by hormonal, environmental, and nutritional factors.Polymorphism of the vitamin D receptor gene has been reported to play a major role in variations for genetic regulation of bone mass but its role within various ethnic populations is not clear. Estrogens are known to play an important role in regulating bone homeostasis, t...

ba0002p47 | (1) | ICCBH2013

Vitamin D deficiency and structural and functional state of bone tissue in schoolchildren of Ukraine

Povoroznyuk Vladyslav , Tyazhka O , Balatska Nataliya , Budnik T , Kubey I , Haliyash N

Introduction: Vitamin D is an essential material in bone metabolism, and regulation of body minerals. Vitamin D deficiency has various causes, including limitations in sunlight exposure (type of clothing, sunscreen usage, indoor activity), seasonal geographic latitude and altitude, atmospheric pollution, diet, and ageing.The aim of the work was to determine the frequency of vitamin D deficiency among Ukrainian schoolchildren and its influence on bone min...