ba0001oc4.4 | Osteoblasts and osteocytes | ECTS2013
, Rauch Alexander
, Tuckermann Jan P
, Hofbauer Lorenz C
, Rauner Martina
Glucocorticoids (GC) are effective drugs in the treatment of inflammatory diseases, including various forms of arthritis. However, their use is limited by negative effects on bone mass and strength, resulting in increased osteoporotic fractures. Conditional knockout mice demonstrated that the GR in osteoblasts is essential for GC-dependent bone loss. Recent studies show that GC profoundly inhibit Wnt signaling by stimulating the expression of Wnt antagonists such as dickkopf-1...