Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp46 | Bone biomechanics and quality | ECTS2013

Low magnitude vibration signals attenuate the rapid bone mass induced by lipopolysaccharide

Kim In Sook , Cho Tae Hyung , Lee Beomseok , Hwang Soon Jung

Introduction: Low-magnitude, high-frequency (LMHF) mechanical stimuli lead to enhance bone formation and decrease resorption. This study aimed to investigate the effect of vibration on the bone loss induced by inflammatory cytokine, lipopolysaccharide (LPS).Methods and designs: Balb-C mice were administered to LPS (5 mg/kg) with two i.p. injections on days 0 and 4, while sham control group was injected with 400 μl of water for injection without LPS....

ba0003pp378 | Other diseases of bone and mineral metabolism | ECTS2014

Zoledronic acid induces apoptosis on osteoblast and inhibits RANKL-induced osteoclast differentiation

Lim Shin Saeng , Kim In Sook , Hwang Soon Jung

Bisphosphonates (BPs) are widely used as antiresorptive drugs. However, one of most potent BPs, zoledronic acid (ZA) can cause BP-related osteonecrosis of the jaws (BRONJ) with a poorly understood pathophysiology. The aim of this study was to find a clue for the development of BRONJ by evaluating the cytotoxic effects of ZA on osteoblasts and examining the action mechanism of ZA on osteoclast differentiation. Jaw bone osteoblasts (JB-OBs), long bone osteoblasts (LB-OBs), and b...

ba0005p70 | Bone development/growth and fracture repair | ECTS2016

Is heparin effective for the controlled delivery of high dose bone morphogeneic protein-2?

Kim In Sook , Kim Ri Youn , Hwang Soon Jung

Sustained release of bone morphogeneic protein (BMP)-2 by heparin-contained biomaterials is advantageous for bone tissue regeneration using low dose BMP-2. However, its effect in high dose BMP-2 is still unclear and should be clarified considering the clinical use of high dose of BMP-2 in spine and oral surgery. This study aimed to evaluate the efficacy of heparin-conjugated collagen sponge (HCS) in high dose BMP-2 delivery by investigating in vivo initial osteogenic regulatio...

ba0005p156 | Cell biology: osteoblasts and bone formation | ECTS2016

The differential effects of zoledronate and etidronate on the in vivo early osseous healing process of an extracted socket and a tibial defect

Kim In Sook , Lim Shin Saeng , Lee Beomseok , Hwang Soon Jung

Bisphosphonates (BPs) are widely used for treating osteoporosis and preventing osseous metastasis or hypercalcemia in cancers. However, osteonecrosis of the jaw in patients treated with BP after dentoalveolar surgery has been increasing, especially in those treated with strong BPs such as zoledronate (ZA). The pathobiology underlying the occurrence of osteonecrosis only in the jaw bone remains unclear. The objective of this study was to compare the effects of BPs on the in...

ba0001pp47 | Bone biomechanics and quality | ECTS2013

Osseous alterations in condylar head after directional change of functional loading in rabbit mandibular condyle

Hwang Soon Jung , Yang Hoon Joo , Cho Tae Hyung , Oh Ji Hye , Kim In Sook

Purpose: The purpose of this study was to investigate the bony change of mandibular condyle when the originally less-loaded or unloaded surface was subjected to functional loading by the newly designed animal experiment, and to evaluate whether this experiment is adequate for the animal model of condylar resorption due to mechanical loading.Methods: Twelve adult male New Zealand white rabbits were used. Unilateral oblique vertical body osteotomy (UOVBO) ...

ba0001pp487 | Other diseases of bone and mineral metabolism | ECTS2013

Preliminary study for the effect of PDGF or mesenchymal stem cells on tissue repair of cutaneous radiation injury

Hwang Soon Jung , Cho Tae Hyung , Lee Beomseok , Oh Ji Hye , Kim In Sook

Purpose: Osteoradionecrosis (ORN) of the mandible is a serious complication of radiation therapy, and preceded by soft tissue damage before bone loss appears. However, there is still no adequate treatment to heal the soft tissue damage of ORN. This study investigated the effect of PDGF-BB or mesenchymal stem cells (rMSCs) on radiation-induced soft tissue injury.Methods: Rat model was designed to irradiate the skin of SD rats while sparing the body and in...

ba0001pp198 | Cell biology: osteoblasts and bone formation | ECTS2013

Estrogen effect on the sclerostin induction by BMP-2 in human mesenchymal stromal cells

Kim In Sook , Yang Hoon Joo , Song Yun Mi , Ryu Soo Jin , Kim Ri Youn , Hwang Soon Jung

Introduction: Estrogen therapy decreases circulating levels of sclerostin, a protein product of SOST which increase in postmenopausal women. However, the mechanisms of estrogen on the expression of SOST remain unclear. This study was hypothesized that estrogen modulates SOST expression by interfering bone morphogenic protein (BMP) signaling on the basis that BMP is an inducer of SOST in osteoblasts.Description of methods: We investigated the expression o...

ba0003pp129 | Cell biology: osteoblasts and bone formation | ECTS2014

Modulation of sclerostin expression by estrogen via BMP-2 signaling in human mesenchymal stromal cells and osteoblasts

Kim Ri Youn , Yang Hoon Joo , Song Yun Mi , Cho Tae Hyung , Hwang Soon Jung , Kim In Sook

Little is known about the molecular mechanisms underlying the interaction between Sclerostin (SOST) and estrogen, showing an inverse relation in clinical data. Therefore, we investigated mechanisms by which estrogen modulates Sost expression at human osteoblastic cell level in association with BMP-2 signaling, which is a potential route of SOST induction. BMP-2 significantly induced SOST expression, which is suppressed by 17β-estradiol (E2) in human mesenchymal s...

ba0005p100 | Cancer and bone: basic, translational and clinical | ECTS2016

The clinicopathological implication of GNAS in ewing sarcoma

Noh Byeong-Joo , Sung Ji-Youn , Kim Youn Wha , Araujo Eduardo Santini , Kalil Ricardo Karam , Jung Woon-Won , Kim Hyun-Sook , Park Yong-Koo

The objective of our study is to determine whether GNAS expression correlates with pathognomonic signs by analyzing mutations, methylation status, and G-protein α subunit (Gsα) expression of GNAS (guanine nucleotide binding protein/α stimulating) gene in Ewing Sarcoma (ES).Formalin-fixed paraffin-embedded (FFPE) tissue samples from 77 patients with primary ES were obtained in Korea, Argentina, and Brazil, and w...

ba0005p271 | Muscle, physical activity and bone | ECTS2016

Skeletal muscle mass is strongly correlated with total Hip BMD in premenopausal women

Lee Sara , Youm Hyun Sik , Song Hye-Kyung , Jeong Kyung-Ah , Kim Joung Sook , Chung Hyewon , Choi Hoon , Kang Byung-moon

Introduction: The significance of sarcopenia and low muscle mass are especially emphasized in these days. Sarcopenia is well known to highly correlate with fragility and increases the risk of falling in the elderly and an important risk factor for disability and mortality. Evidence of inter-relaionship of muscle with bone metabolism is increasing. Therefore we investigated the relationship between BMD and muscle mass among healthy Korean premenopausal women.<p class="abste...