Searchable abstracts of presentations at key conferences on calcified tissues

ba0001pp368 | Osteoporosis: pathophysiology and epidemiology | ECTS2013

Portuguese and spanish FRAX® tool versions: a comparative analysis from EpiReumaPt

Gouveia Nelia , Canhao Helena , Rego Tania , Sousa Susana , Branco Jaime

EpiReumaPt is a cross-sectional, epidemiologic study to estimate the prevalence of rheumatic diseases in Portugal. Selected cases randomized from the 10 000 Portuguese subjects recruited are eventually observed by a rheumatologist. Portuguese and Spanish FRAX® tool were applied. The major osteoporotic (MOFR) and hip (HFR) fracture risk were calculated without DXA results.The FRAX tool has been developed by WHO to evaluate 10 years fracture risk. It ...

ba0001pp23 | Arthritis and other joint diseases: translational and clinical | ECTS2013

Ultrasound carotid plaque morphology in rheumatoid arthritis women without previous cardiovascular events

Castro Alice , Carmona-Fernandes Diana , Santos Maria Jose , Mendes-Pedro Luis , Canhao Helena , Fonseca Joao Eurico

Introduction: In rheumatoid arthritis (RA) patients subclinical atherosclerosis and cardiovascular events (CV) occur more frequently and at younger ages than in the general population. Previous data suggest that heterogeneous plaques on USA are more unstable and frequently contain a higher amount of lipids and which make them hypoechoic and had higher potential for embolization and thrombosis. The aim of our work was to estimate the prevalence and the ultrasound morphology of ...

ba0001pp327 | Osteoporosis: evaluation and imaging | ECTS2013

BMA assessment standard curves for wrist and ankle of both sexes: data from EpiReumaPt

Canhao Helena , Gouveia Nelia , Rego Tania , Rodrigues Ana Maria , Branco Jaime

Introduction: To determine bone microarchitecture analysis (BMA) standard curves for wrist and ankle in men and women.Design: EpiReumaPt is an ongoing national, population-based, cross-sectional, epidemiologic study developed by the Portuguese Society of Rheumatology to estimate the prevalence of rheumatic diseases in Portugal. Trained interviewers have been randomly applying a standardized questionnaire to 10 000 subjects at their houses. Selected cases...

ba0005p38 | Bone biomechanics and quality | ECTS2016

Arthritis induces early bone structural degradation and mechanical weakness

Vidal Bruno , Cascao Rita , Finnila Mikko , Lopes Ines , Saarakkala Simo , Canhao Helena , Fonseca Joao

Background: We have previously found in the chronic SKG mouse model of arthritis that long standing (5 and 8 months) inflammation directly leads to high collagen bone turnover, disorganization of the collagen network, disturbed bone microstructure and ultimately declining in bone biomechanical properties. Our main goal was to study the effects of the inflammatory process on the microarchitecture and mechanical properties of bone in the early stages of arthritis development.</p...

ba0002p124 | (1) | ICCBH2013

Adipokines and bone turnover throughout adolescence: an exploratory approach in a cohort of girls

Monjardino Teresa , Ramos Elisabete , Lucas Raquel , Prata Margarida , Severo Milton , Rodrigues Ana , Canhao Helena , Fonseca Joao Eurico , Barros Henrique

Objectives: By prospectively evaluating a cohort of girls we aim to identify population patterns linking adipokines and bone turnover during early and late adolescence and to assess the associations of those patterns with forearm bone mineral density (BMD).Methods: The study was developed within a population-based cohort of urban adolescents born in 1990 and assembled in public and private schools of Porto, Portugal (EPITeen). We analysed prospective dat...

ba0003pp13 | Arthritis and other joint diseases: translational and clinical | ECTS2014

RANK expression is reduced in circulating monocytes from ankylosing spondylitis patients

Perpetuo Ines Pedro , Caetano-Lopes Joana , Vieira-Sousa Elsa , Campanilho-Marques Raquel , Ponte Cristina , Canhao Helena , Ainola Mari , Fonseca Joao Eurico

Rheumatoid arthritis (RA) and ankylosing spondylitis (AS) are systemic, immune-mediated diseases. RA’s main targets are the peripheral joints while AS has the axial skeleton and enthesis as the principal affected areas. RA is characterized by bone erosions and impaired repair whilst AS is typified by bone overgrowth. The causes for these differences are not yet understood; however we hypothesize that AS patients’ monocytes receive reduced osteoclastogenic stimuli and...

ba0001pp367 | Osteoporosis: pathophysiology and epidemiology | ECTS2013

Estimated glomerular filtration rate is associated with bone fragility in the elderly

Goncalves Maria Joao , Rodrigues Ana , Caetano-Lopes Joana , Raquel Emilia , Lopes Ana , Vidal Bruno , Vale Ana Catarina , Sarmento Marco , Vaz Maria Fatima , Monteiro Jacinto , Fonseca Joao Eurico , Canhao Helena

Introduction: Osteoporosis is frequently associated with renal disease, namely the bone metabolism disturbances caused by secondary hyperparathyroidism of chronic kidney disease (CKD). The increased risk of fragility fractures is well demonstrated in patients with end-stage renal disease (ESRD). There is recent evidence that bone pathological changes start early in the course of CKD. Our aim is to evaluate whether chronic renal disease, before ESRD, is associated with bone fra...

ba0005p8 | Arthritis and other joint diseases: translational and clinical | ECTS2016

A clinical study to examine thresholds of joint space width and joint space area for identification of knee osteoarthritis

Ljuhar Richard , Norman Benjamin , Ljuhar Davul , Haftner Tobias , Hladuvka Jiri , Mai Mary Bui Thi , Canhao Helena , Rodrigues Ana Maria , Gouveia Nelia , Branco Jaime , Nehrer Stefan , Fahrleitner-Pammer Astrid , Dimai Hans-Peter

Objective: Osteoarthritis (OA) is a degenerative, slowly developing joint disease. Although clinical indications of OA can vary among different definitions there is a general agreement that the disease is associated with cartilage narrowing. However, there is no general consensus about the threshold below which the joint space width (JSW)/joint space area (JSA) can be certain indicators for the state of OA. Therefore this study evaluates these limits to reveal quantitative inf...

ba0005p302 | Osteoporosis: evaluation and imaging | ECTS2016

A novel feature selection algorithm based on bone micro architecture analysis to identify osteoarthritis

Ljuhar Richard , Norman Benjamin , Ljuhar Davul , Haftner Tobias , Hladuvka Jiri , Bui Thi Mai Mary , Canhao Helena , MariaRodrigues Ana , Gouveia Nelia , Branco Jaime , Nehrer Stefan , Fahrleitner-Pammer Astrid , Dimai Hans-Peter

Objective: Texture information of the subchondral bone area (SBA) of 2D radiographs represents a promising possibility for evaluating the state of osteoarthritis (OA). However such features are likely to vary within the SBA and therefore the selection of the region of interest (ROI) plays a crucial role. Thus, a feature selection algorithm (FSA) is being applied in order to determine ROIs that enable an optimum discrimination between patients with and without OA.<p class="...