Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p320 | Osteoporosis: evaluation and imaging | ECTS2016

Age and sex features of femoral geometry in patients with hip fractures

Grygorieva Nataliia , Zubach O

According to the literature data, some parameters of the femur (length of axis, length of femoral neck) are independent predictors of hip fractures, but such studies among Ukrainian patients are absent. The purpose of this study was to study age and gender features of some geometric parameters of the upper third of the hip in patients with intra- and extra-articular fractures of the femur.One hundred and seventy-four survey radiographs of the hip joints ...

ba0001pp340 | Osteoporosis: evaluation and imaging | ECTS2013

Trabecular bone score and bone mineral density of lumbar spine in healthy women: pros and cons

Povoroznyuk Vladyslav , Lamy O , Dzerovych Nataliia , Hans Didier

Areal bone mineral density (aBMD) of the PA spine and proximal femur remained the gold standard for WHO classification of osteoporosis, fracture prediction and patient monitoring. Unfortunately, with age it is not infrequent to observe the presence of degenerative disease such as spinal osteoarthritis which would have a positive artifactual impact on aBMD which could lead to an erroneous interpretation. In a previous study it has been demonstrated that apparently such artifact...

ba0003pp281 | Osteoporosis: pathophysiology and epidemiology | ECTS2014

State of vitamin D sufficiency Ukrainian schoolchildren

Povoroznyuk Vladyslav , Balatska Nataliya , Budnik Tetyana , Erokchina O

Background: It is now known that the osteoporosis starts developing childhood. Children’s age is characterized by intensive accumulation of bone mass. By the end of puberty the level of bone mass in many parts of the skeleton reaches 86% of the bone mass of an adult and in some parts it reaches 100%.The processes of bone metabolism closely connected with the level of the vitamin D, in the body because it has a pronounced effect on calcium homeostasi...

ba0005p1 | Arthritis and other joint diseases: translational and clinical | ECTS2016

The role of fibroblast growth factor in the destruction in rheumatoid arthritis

Komarova E B , Blagodarenko A B , Rebrova O A , Kurennoy A B

The main cause of the bone destruction in rheumatoid arthritis (RA) is a destructive act of aggressively growing pannus, growth and angiogenesis of which are caused by the proliferation of fibroblasts in the synovium (S) due to the activation of fibroblast growth factor (FGF).Objectives: To reveal relationships of FGF with ultrasonic and arthroscopic and proliferative-destructive histological figures in RA.Methods: Complete compreh...

ba0007p123 | (1) | ICCBH2019

Odontochondrodysplasia in association with a TRIP11 mutation

Sheridan Sabrina , McCarron Laura , Donnell Gillian O , McDonnell Ciara

Background: Pathogenic mutations in thyroid hormone receptor interactor 11 (TRIP11) have previously been associated with achondrogenesis1A, a lethal autosomal recessive skeletal dysplasia. Recent findings have suggested that hypomorphic mutations of TRIP11 result in odontochondrodysplasia (ODCD), a rare syndrome associated with spondylometaphyseal dysplasia and dentinogenesis imperfecta.Presenting problem: This is the case of a term female born to non-co...

ba0002p47 | (1) | ICCBH2013

Vitamin D deficiency and structural and functional state of bone tissue in schoolchildren of Ukraine

Povoroznyuk Vladyslav , Tyazhka O , Balatska Nataliya , Budnik T , Kubey I , Haliyash N

Introduction: Vitamin D is an essential material in bone metabolism, and regulation of body minerals. Vitamin D deficiency has various causes, including limitations in sunlight exposure (type of clothing, sunscreen usage, indoor activity), seasonal geographic latitude and altitude, atmospheric pollution, diet, and ageing.The aim of the work was to determine the frequency of vitamin D deficiency among Ukrainian schoolchildren and its influence on bone min...

ba0003pp63 | Bone development/growth and fracture repair | ECTS2014

Adiponectin induce elasticity of bones

Haugen Sigrid , Sundaresan Alamelu , Tiainen Hanna , Stunes Kamilla , Syversen Unni , Gordeladze Jan O , Reseland Janne

It is known that body weight is positively correlated with increased bone mineral density and decreased fracture risk. Adiponectin is expressed in bone forming cells, and administration of adiponectin has been demonstrated to stimulated osteoblast proliferation. The overall role of adiponectin in bone metabolism remains unrevealed as both stimulated and inhibiting effects on osteoclastogenesis have been reported. We aimed at describing the relationship between adiponectin and ...

ba0003pp252 | Osteoporosis: evaluation and imaging | ECTS2014

The development of a mathematical model to predict the time to osteoporosis using DEXA scanning

Scully Paul , Peters Catherine , Carew Sheila , Sheehy Tina , Costello Aine , Connor Margaret O , Lyons Declan

Background: Dual-energy X-ray absorptiometry (DEXA) is the gold standard used for measuring bone mineral density and such readings are currently used to predict osteoporosis and osteoporotic fractures. However, no similar prediction model has been developed to identify the age that a patient will become osteoporotic based on DEXA scanning.Objective: The aim of this study was to develop a mathematical model to determine the TTO based on two or more DEXA s...

ba0006p107 | (1) | ICCBH2017

A case of a novel de novo PLS3 deletion, presenting with vertebral fractures and mild dysmorphism

Doulgeraki A. , Costantini A. , Kampe A. , Karavitakis E. , Jantti N. , Krallis P. , Athanasopoulou H. , Xaidara A. , Makitie O.

Background: Mutations in the PLS3 gene, encoding plastin 3, cause X-linked osteoporosis. Osteoporosis is characterized by low bone mineral density (BMD) and increased susceptibility to fractures. Here we describe a 7-year-old boy with osteoporosis due to a novel PLS3 deletion.Presenting problem: The patient, born to non-consanguineous parents, had a history of one low-energy long-bone fracture, three vertebral fractures (T5, T6 T8) and kyphosis. DXA scan...

ba0007p226 | (1) | ICCBH2019

The experience of canakinumab in 2 patients with primary tumor (tumoral) calcinosis

Kostik M , Petukhova V , Pigareva T , Likhacheva T , Idrisova R , Snegireva L , Krasnogorskaya O , Suspisin E

Background: Primary tumoral calcinosis is an orphan disease. The data about the incidence of this disease, as well as clinical recommendations for treatment are not presented in the literature.Presenting problem: Two patients – 11.5 years old boy and 8 years old girl with primary tumoral calcinosis had multiple foci of the subcutaneous calcification, walking impossibility, wheel-chair condition, fatigue, high fever and equinus deformity of the left ...